Open Access

PLoS ONE, volume 6, issue 2, pages e16955

Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish

Anchelin Monique ¹

Murcia Laura ¹

Alcaraz-Pérez Francisca ¹

García Navarro Esther M ¹

Cayuela María L. ¹

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Telomerase, Aging and Cancer Group, Research Unit, Department of Surgery, CIBERehd, University Hospital “Virgen de la Arrixaca”, Murcia, Spain |

Publication type: Journal Article

Publication date: 2011-02-09

Public Library of Science (PLoS)

Journal: PLoS ONE

Quartile SCImago

Quartile WOS

Impact factor: 3.7

ISSN: 19326203

DOI: 10.1371/journal.pone.0016955

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PubMed ID: 21347393

Multidisciplinary

Abstract

Telomere length and telomerase activity are important factors in the pathobiology of human diseases. Age-related diseases and premature aging syndromes are characterized by short telomeres, which can compromise cell viability, whereas tumour cells can prevent telomere loss by aberrantly upregulating telomerase. The zebrafish (Danio rerio) offers multiple experimental manipulation advantages over other vertebrate models and, therefore, it has been recently considered as a potential model for aging, cancer, and regeneration studies. However, it has only partially been exploited to shed light on these fundamental biological processes. The aim of this study was, therefore, to investigate telomere length and telomerase expression and activity in different strains of zebrafish obtained from different stock centres to determine whether they undergo any changes during aging and regeneration. We found that although both telomerase expression and telomere length increased from embryo to adulthood stages, they drastically declined in aged fish despite telomerase activity was detected in different tissues of old fish. In addition, we observed a weaker upregulation of telomerase expression in regenerating fins of old fish, which well correlates with their impaired regeneration capacity. Strikingly, telomeres were elongated or maintained during the fin regeneration process at all ages and after repeated amputations, likely to support high cell proliferation rates. We conclude that the expression of telomerase and telomere length are closely related during the entire life cycle of the fish and that these two parameters can be used as biomarkers of aging in zebrafish. Our results also reveal a direct relationship between the expression of telomerase, telomere length and the efficiency of tissue regeneration.

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Molecular Ecology	Molecular Ecology, 6, 4.88% Molecular Ecology 6 publications, 4.88%
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Philosophical Transactions of the Royal Society B: Biological Sciences	Philosophical Transactions of the Royal Society B: Biological Sciences, 2, 1.63% Philosophical Transactions of the Royal Society B: Biological Sciences 2 publications, 1.63%
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Ecology and Evolution	Ecology and Evolution, 2, 1.63% Ecology and Evolution 2 publications, 1.63%
Biological Reviews	Biological Reviews, 2, 1.63% Biological Reviews 2 publications, 1.63%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 2, 1.63% Proceedings of the National Academy of Sciences of the United States of America 2 publications, 1.63%
Doklady Biochemistry and Biophysics	Doklady Biochemistry and Biophysics, 1, 0.81% Doklady Biochemistry and Biophysics 1 publication, 0.81%
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Journal of Applied Genetics	Journal of Applied Genetics, 1, 0.81% Journal of Applied Genetics 1 publication, 0.81%
Molecular Biology Reports	Molecular Biology Reports, 1, 0.81% Molecular Biology Reports 1 publication, 0.81%
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Citations by publishers

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Elsevier	Elsevier, 22, 17.89% Elsevier 22 publications, 17.89%
Wiley	Wiley, 19, 15.45% Wiley 19 publications, 15.45%
Springer Nature	Springer Nature, 16, 13.01% Springer Nature 16 publications, 13.01%
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Frontiers Media S.A.	Frontiers Media S.A., 5, 4.07% Frontiers Media S.A. 5 publications, 4.07%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 5, 4.07% Public Library of Science (PLoS) 5 publications, 4.07%
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Oxford University Press	Oxford University Press, 3, 2.44% Oxford University Press 3 publications, 2.44%
Mary Ann Liebert	Mary Ann Liebert, 2, 1.63% Mary Ann Liebert 2 publications, 1.63%
Taylor & Francis	Taylor & Francis, 2, 1.63% Taylor & Francis 2 publications, 1.63%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 2, 1.63% Proceedings of the National Academy of Sciences (PNAS) 2 publications, 1.63%
University of Chicago Press	University of Chicago Press, 1, 0.81% University of Chicago Press 1 publication, 0.81%
S. Karger AG	S. Karger AG, 1, 0.81% S. Karger AG 1 publication, 0.81%
Portland Press	Portland Press, 1, 0.81% Portland Press 1 publication, 0.81%
SAGE	SAGE, 1, 0.81% SAGE 1 publication, 0.81%
eLife Sciences Publications	eLife Sciences Publications, 1, 0.81% eLife Sciences Publications 1 publication, 0.81%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 1, 0.81% Cold Spring Harbor Laboratory 1 publication, 0.81%
PeerJ	PeerJ, 1, 0.81% PeerJ 1 publication, 0.81%
	5 10 15 20 25

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Anchelin M. et al. Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish // PLoS ONE. 2011. Vol. 6. No. 2. p. e16955.

GOST all authors (up to 50) Copy

Anchelin M., Murcia L., Alcaraz-Pérez F., García Navarro E. M., Cayuela M. L. Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish // PLoS ONE. 2011. Vol. 6. No. 2. p. e16955.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1371/journal.pone.0016955

UR - https://doi.org/10.1371%2Fjournal.pone.0016955

TI - Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish

T2 - PLoS ONE

AU - Anchelin, Monique

AU - Murcia, Laura

AU - Alcaraz-Pérez, Francisca

AU - García Navarro, Esther M

AU - Cayuela, María L.

PY - 2011

DA - 2011/02/09 00:00:00

PB - Public Library of Science (PLoS)

SP - e16955

IS - 2

VL - 6

PMID - 21347393

SN - 1932-6203

ER -

BibTex |

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BibTex Copy

@article{2011_Anchelin,

author = {Monique Anchelin and Laura Murcia and Francisca Alcaraz-Pérez and Esther M García Navarro and María L. Cayuela},

title = {Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish},

journal = {PLoS ONE},

year = {2011},

volume = {6},

publisher = {Public Library of Science (PLoS)},

month = {feb},

url = {https://doi.org/10.1371%2Fjournal.pone.0016955},

number = {2},

pages = {e16955},

doi = {10.1371/journal.pone.0016955}

}

MLA

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MLA Copy

Anchelin, Monique, et al. “Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish.” PLoS ONE, vol. 6, no. 2, Feb. 2011, p. e16955. https://doi.org/10.1371%2Fjournal.pone.0016955.

Found error?

Publisher

Public Library of Science (PLoS)

Journal

PLoS ONE

Quartile SCImago

Quartile WOS

Impact factor

3.7

ISSN

19326203 (Print)