Open Access
PLoS ONE, volume 6, issue 2, pages e16955
Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish
Anchelin Monique
1
,
Murcia Laura
1
,
Alcaraz-Pérez Francisca
1
,
García Navarro Esther M
1
,
Cayuela María L.
1
1
Telomerase, Aging and Cancer Group, Research Unit, Department of Surgery, CIBERehd, University Hospital “Virgen de la Arrixaca”, Murcia, Spain
|
Publication type: Journal Article
Publication date: 2011-02-09
PubMed ID:
21347393
Multidisciplinary
Abstract
Telomere length and telomerase activity are important factors in the pathobiology of human diseases. Age-related diseases and premature aging syndromes are characterized by short telomeres, which can compromise cell viability, whereas tumour cells can prevent telomere loss by aberrantly upregulating telomerase. The zebrafish (Danio rerio) offers multiple experimental manipulation advantages over other vertebrate models and, therefore, it has been recently considered as a potential model for aging, cancer, and regeneration studies. However, it has only partially been exploited to shed light on these fundamental biological processes. The aim of this study was, therefore, to investigate telomere length and telomerase expression and activity in different strains of zebrafish obtained from different stock centres to determine whether they undergo any changes during aging and regeneration. We found that although both telomerase expression and telomere length increased from embryo to adulthood stages, they drastically declined in aged fish despite telomerase activity was detected in different tissues of old fish. In addition, we observed a weaker upregulation of telomerase expression in regenerating fins of old fish, which well correlates with their impaired regeneration capacity. Strikingly, telomeres were elongated or maintained during the fin regeneration process at all ages and after repeated amputations, likely to support high cell proliferation rates. We conclude that the expression of telomerase and telomere length are closely related during the entire life cycle of the fish and that these two parameters can be used as biomarkers of aging in zebrafish. Our results also reveal a direct relationship between the expression of telomerase, telomere length and the efficiency of tissue regeneration.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Anchelin M. et al. Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish // PLoS ONE. 2011. Vol. 6. No. 2. p. e16955.
GOST all authors (up to 50)
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Anchelin M., Murcia L., Alcaraz-Pérez F., García Navarro E. M., Cayuela M. L. Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish // PLoS ONE. 2011. Vol. 6. No. 2. p. e16955.
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RIS
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TY - JOUR
DO - 10.1371/journal.pone.0016955
UR - https://doi.org/10.1371%2Fjournal.pone.0016955
TI - Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish
T2 - PLoS ONE
AU - Anchelin, Monique
AU - Murcia, Laura
AU - Alcaraz-Pérez, Francisca
AU - García Navarro, Esther M
AU - Cayuela, María L.
PY - 2011
DA - 2011/02/09 00:00:00
PB - Public Library of Science (PLoS)
SP - e16955
IS - 2
VL - 6
PMID - 21347393
SN - 1932-6203
ER -
Cite this
BibTex
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@article{2011_Anchelin,
author = {Monique Anchelin and Laura Murcia and Francisca Alcaraz-Pérez and Esther M García Navarro and María L. Cayuela},
title = {Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish},
journal = {PLoS ONE},
year = {2011},
volume = {6},
publisher = {Public Library of Science (PLoS)},
month = {feb},
url = {https://doi.org/10.1371%2Fjournal.pone.0016955},
number = {2},
pages = {e16955},
doi = {10.1371/journal.pone.0016955}
}
Cite this
MLA
Copy
Anchelin, Monique, et al. “Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish.” PLoS ONE, vol. 6, no. 2, Feb. 2011, p. e16955. https://doi.org/10.1371%2Fjournal.pone.0016955.