Open Access
PLoS ONE, volume 7, issue 10, pages e46642
A Fish-Specific Transposable Element Shapes the Repertoire of p53 Target Genes in Zebrafish
Micale Lucia
1
,
Loviglio Maria Nicla
2
,
MANZONI Marta
3
,
Fusco Carmela
1
,
Augello Bartolomeo
1
,
Migliavacca Eugenia
4
,
Cotugno Grazia
1
,
Monti Eugenio
3
,
BORSANI Giuseppe
3
,
Reymond Alexandre
4
,
Merla Giuseppe
1
1
Publication type: Journal Article
Publication date: 2012-10-31
PubMed ID:
23118857
Multidisciplinary
Abstract
Transposable elements, as major components of most eukaryotic organisms' genomes, define their structural organization and plasticity. They supply host genomes with functional elements, for example, binding sites of the pleiotropic master transcription factor p53 were identified in LINE1, Alu and LTR repeats in the human genome. Similarly, in this report we reveal the role of zebrafish (Danio rerio) EnSpmN6_DR non-autonomous DNA transposon in shaping the repertoire of the p53 target genes. The multiple copies of EnSpmN6_DR and their embedded p53 responsive elements drive in several instances p53-dependent transcriptional modulation of the adjacent gene, whose human orthologs were frequently previously annotated as p53 targets. These transposons define predominantly a set of target genes whose human orthologs contribute to neuronal morphogenesis, axonogenesis, synaptic transmission and the regulation of programmed cell death. Consistent with these biological functions the orthologs of the EnSpmN6_DR-colonized loci are enriched for genes expressed in the amygdala, the hippocampus and the brain cortex. Our data pinpoint a remarkable example of convergent evolution: the exaptation of lineage-specific transposons to shape p53-regulated neuronal morphogenesis-related pathways in both a hominid and a teleost fish.
Citations by journals
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1 publication, 5.88%
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1 publication, 5.88%
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1 publication, 5.88%
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Genome Research
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1 publication, 5.88%
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1
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Citations by publishers
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1
2
3
4
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Springer Nature
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4 publications, 23.53%
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Public Library of Science (PLoS)
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2 publications, 11.76%
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Wiley
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1 publication, 5.88%
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1 publication, 5.88%
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1 publication, 5.88%
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Taylor & Francis
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1 publication, 5.88%
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Oxford University Press
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1 publication, 5.88%
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American Association for the Advancement of Science (AAAS)
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1 publication, 5.88%
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Cold Spring Harbor Laboratory
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Cold Spring Harbor Laboratory
1 publication, 5.88%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Micale L. et al. A Fish-Specific Transposable Element Shapes the Repertoire of p53 Target Genes in Zebrafish // PLoS ONE. 2012. Vol. 7. No. 10. p. e46642.
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Micale L., Loviglio M. N., MANZONI M., Fusco C., Augello B., Migliavacca E., Cotugno G., Monti E., BORSANI G., Reymond A., Merla G. A Fish-Specific Transposable Element Shapes the Repertoire of p53 Target Genes in Zebrafish // PLoS ONE. 2012. Vol. 7. No. 10. p. e46642.
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TY - JOUR
DO - 10.1371/journal.pone.0046642
UR - https://doi.org/10.1371%2Fjournal.pone.0046642
TI - A Fish-Specific Transposable Element Shapes the Repertoire of p53 Target Genes in Zebrafish
T2 - PLoS ONE
AU - Micale, Lucia
AU - Loviglio, Maria Nicla
AU - MANZONI, Marta
AU - Fusco, Carmela
AU - Augello, Bartolomeo
AU - Migliavacca, Eugenia
AU - Cotugno, Grazia
AU - Monti, Eugenio
AU - BORSANI, Giuseppe
AU - Reymond, Alexandre
AU - Merla, Giuseppe
PY - 2012
DA - 2012/10/31 00:00:00
PB - Public Library of Science (PLoS)
SP - e46642
IS - 10
VL - 7
PMID - 23118857
SN - 1932-6203
ER -
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@article{2012_Micale,
author = {Lucia Micale and Maria Nicla Loviglio and Marta MANZONI and Carmela Fusco and Bartolomeo Augello and Eugenia Migliavacca and Grazia Cotugno and Eugenio Monti and Giuseppe BORSANI and Alexandre Reymond and Giuseppe Merla},
title = {A Fish-Specific Transposable Element Shapes the Repertoire of p53 Target Genes in Zebrafish},
journal = {PLoS ONE},
year = {2012},
volume = {7},
publisher = {Public Library of Science (PLoS)},
month = {oct},
url = {https://doi.org/10.1371%2Fjournal.pone.0046642},
number = {10},
pages = {e46642},
doi = {10.1371/journal.pone.0046642}
}
Cite this
MLA
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Micale, Lucia, et al. “A Fish-Specific Transposable Element Shapes the Repertoire of p53 Target Genes in Zebrafish.” PLoS ONE, vol. 7, no. 10, Oct. 2012, p. e46642. https://doi.org/10.1371%2Fjournal.pone.0046642.