Open Access
PLoS ONE, volume 9, issue 1, pages e87228
Survival of Neural Stem Cells Undergoing DNA Damage-Induced Astrocytic Differentiation in Self-Renewal-Promoting Conditions In Vitro
1
IFOM Foundation - The FIRC Institute of Molecular Oncology Foundation, Milan, Italy,
|
Publication type: Journal Article
Publication date: 2014-01-27
PubMed ID:
24475256
Multidisciplinary
Abstract
We recently reported that neural stem cells (NSCs) become senescent and commit to astrocytic differentiation upon X-ray irradiation. Surprisingly, under self-renewing culture conditions, some of these senescent cells undergo p53-independent apoptosis, which can be suppressed by caspase inhibition and BCL2 overexpression. Inhibition of apoptosis proved beneficial for astroglial differentiation efficiency; hence the toxicity of DNA damage on NSCs was specifically tested in context of the culture conditions. In this regard, self-renewal-promoting culture conditions proved incompatible with terminal astrocyte differentiation and impacted negatively on the viability of NSCs following DNA damage-induced cell cycle exit. On the contrary, a switch to differentiation-supporting conditions ablated apoptosis and conveyed tolerance to DNA damage. Thus, stem cell death has likely not originated from DNA break toxicity, while the potentially confounding effect of stem cell niche should always be taken in consideration in stem cell irradiation experiments.
Citations by journals
|
1
|
|
|
Nucleus
|
Nucleus
1 publication, 10%
|
|
Oncotarget
|
Oncotarget
1 publication, 10%
|
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
1 publication, 10%
|
|
Frontiers in Aging Neuroscience
|
Frontiers in Aging Neuroscience
1 publication, 10%
|
|
Molecular Neurobiology
|
Molecular Neurobiology
1 publication, 10%
|
|
Brain, Behavior, and Immunity
|
Brain, Behavior, and Immunity
1 publication, 10%
|
|
GLIA
|
GLIA
1 publication, 10%
|
|
Advances in Molecular Toxicology
|
Advances in Molecular Toxicology
1 publication, 10%
|
|
National Science Review
|
National Science Review
1 publication, 10%
|
|
Scientific Reports
|
Scientific Reports
1 publication, 10%
|
|
1
|
Citations by publishers
|
1
2
|
|
|
Springer Nature
|
Springer Nature
2 publications, 20%
|
|
Elsevier
|
Elsevier
2 publications, 20%
|
|
Taylor & Francis
|
Taylor & Francis
1 publication, 10%
|
|
Impact Journals
|
Impact Journals
1 publication, 10%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 10%
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
1 publication, 10%
|
|
Wiley
|
Wiley
1 publication, 10%
|
|
Oxford University Press
|
Oxford University Press
1 publication, 10%
|
|
1
2
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2014,2015,2016,2017,2018,2019,2020,2021,2022,2023],"ids":[0,0,0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","","","",""],"datasets":[{"label":"Citations number","data":[1,2,1,2,0,0,1,2,0,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["10","20","10","20",0,0,"10","20",0,"10"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Nucleus","Oncotarget","International Journal of Molecular Sciences","Frontiers in Aging Neuroscience","Molecular Neurobiology","Brain, Behavior, and Immunity","GLIA","Advances in Molecular Toxicology","National Science Review","Scientific Reports"],"ids":[5407,8484,14627,13362,24041,4943,5953,2735,10279,13767],"codes":[0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[10,10,10,10,10,10,10,10,10,10],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Springer Nature","Elsevier","Taylor & Francis","Impact Journals","Multidisciplinary Digital Publishing Institute (MDPI)","Frontiers Media S.A.","Wiley","Oxford University Press"],"ids":[8,17,18,342,202,208,11,19],"codes":[0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp"],"datasets":[{"label":"","data":[2,2,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[20,20,10,10,10,10,10,10],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Schneider L. Survival of Neural Stem Cells Undergoing DNA Damage-Induced Astrocytic Differentiation in Self-Renewal-Promoting Conditions In Vitro // PLoS ONE. 2014. Vol. 9. No. 1. p. e87228.
GOST all authors (up to 50)
Copy
Schneider L. Survival of Neural Stem Cells Undergoing DNA Damage-Induced Astrocytic Differentiation in Self-Renewal-Promoting Conditions In Vitro // PLoS ONE. 2014. Vol. 9. No. 1. p. e87228.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1371/journal.pone.0087228
UR - https://doi.org/10.1371%2Fjournal.pone.0087228
TI - Survival of Neural Stem Cells Undergoing DNA Damage-Induced Astrocytic Differentiation in Self-Renewal-Promoting Conditions In Vitro
T2 - PLoS ONE
AU - Schneider, Leonid
PY - 2014
DA - 2014/01/27 00:00:00
PB - Public Library of Science (PLoS)
SP - e87228
IS - 1
VL - 9
PMID - 24475256
SN - 1932-6203
ER -
Cite this
BibTex
Copy
@article{2014_Schneider,
author = {Leonid Schneider},
title = {Survival of Neural Stem Cells Undergoing DNA Damage-Induced Astrocytic Differentiation in Self-Renewal-Promoting Conditions In Vitro},
journal = {PLoS ONE},
year = {2014},
volume = {9},
publisher = {Public Library of Science (PLoS)},
month = {jan},
url = {https://doi.org/10.1371%2Fjournal.pone.0087228},
number = {1},
pages = {e87228},
doi = {10.1371/journal.pone.0087228}
}
Cite this
MLA
Copy
Schneider, Leonid. “Survival of Neural Stem Cells Undergoing DNA Damage-Induced Astrocytic Differentiation in Self-Renewal-Promoting Conditions In Vitro.” PLoS ONE, vol. 9, no. 1, Jan. 2014, p. e87228. https://doi.org/10.1371%2Fjournal.pone.0087228.