Open Access
PLoS ONE, volume 15, issue 1, pages e0227174
Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells
1
Cell Collection and Research Center, National Institutes for Food and Drug Control, Beijing, China
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Publication type: Journal Article
Publication date: 2020-01-03
PubMed ID:
31900469
Multidisciplinary
Abstract
BEAS-2B was originally established as an immortalized but non-tumorigenic epithelial cell line from human bronchial epithelium. Because of general recognition for its bronchial epithelial origin, the BEAS-2B cell line has been widely used as an in vitro cell model in a large variety of studies associated with respiratory diseases including lung carcinogenesis. However, very few studies have discussed non-epithelial features of BEAS-2B cells, especially the features associated with mesenchymal stem cells (MSCs), which represent a group of fibroblast-like cells with limited self-renewal and differentiation potential to various cell lineages. In this study, we compared BEAS-2B with a human umbilical cord-derived MSCs (hMSCs) cell line, hMSC1, which served as a representative of hMSCs in terms of expressing common features of hMSCs. It was observed that both BEAS-2B and hMSC1 shared the same expression profile of surface markers of hMSCs and exhibited similar osteogenic and adipogenic differentiation potential. In addition, like hMSC1, the BEAS-2B cell line exhibited suppressive activities on proliferation of mitogen-activated total T lymphocytes as well as Th1 lymphocytes, and IFNγ-induced expression of IDO1, all thus demonstrating that BEAS-2B cells exhibited an almost identical characteristic profile with hMSCs, even though, there was a clear difference between BEAS-2B and hMSCs in the effects on type 2 macrophage polarization. Most importantly, the hMSCs features of BEAS-2B were unlikely a consequence of epithelial-mesenchymal transition. Therefore, this study provided a set of evidence to provoke reconsideration of epithelial origin of BEAS-2B.
Citations by journals
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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8 publications, 25%
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Elsevier
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Wiley
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4 publications, 12.5%
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Springer Nature
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American Chemical Society (ACS)
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1 publication, 3.13%
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Mary Ann Liebert
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1 publication, 3.13%
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King Saud University
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King Saud University
1 publication, 3.13%
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Hindawi Limited
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1 publication, 3.13%
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Oxford University Press
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Oxford University Press
1 publication, 3.13%
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Taylor & Francis
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1 publication, 3.13%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Han X. et al. Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells // PLoS ONE. 2020. Vol. 15. No. 1. p. e0227174.
GOST all authors (up to 50)
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Han X., Tao N., Wu T., Yuan B. Z. Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells // PLoS ONE. 2020. Vol. 15. No. 1. p. e0227174.
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TY - JOUR
DO - 10.1371/journal.pone.0227174
UR - https://doi.org/10.1371%2Fjournal.pone.0227174
TI - Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells
T2 - PLoS ONE
AU - Han, Xiaoyan
AU - Tao, Na
AU - Wu, Tingting
AU - Yuan, Bao Zhu
PY - 2020
DA - 2020/01/03 00:00:00
PB - Public Library of Science (PLoS)
SP - e0227174
IS - 1
VL - 15
PMID - 31900469
SN - 1932-6203
ER -
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@article{2020_Han,
author = {Xiaoyan Han and Na Tao and Tingting Wu and Bao Zhu Yuan},
title = {Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells},
journal = {PLoS ONE},
year = {2020},
volume = {15},
publisher = {Public Library of Science (PLoS)},
month = {jan},
url = {https://doi.org/10.1371%2Fjournal.pone.0227174},
number = {1},
pages = {e0227174},
doi = {10.1371/journal.pone.0227174}
}
Cite this
MLA
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Han, Xiaoyan, et al. “Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells.” PLoS ONE, vol. 15, no. 1, Jan. 2020, p. e0227174. https://doi.org/10.1371%2Fjournal.pone.0227174.