Expert Opinion on Investigational Drugs, volume 17, issue 4, pages 547-553
OPT-80, a macrocyclic antimicrobial agent for the treatment ofClostridium difficileinfections: a review
Publication type: Journal Article
Publication date: 2008-03-25
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6.1
ISSN: 13543784, 17447658
Abstract
Background: Clostridium difficile-associated diarrhoea has become a major problem over the last years. Increasing incidence and more severe clinical cases initiated the search for new treatment options. Objective: OPT-80, also known as tiacumicin B, lipiarmycin or PAR-101, is a macrocyclic antimicrobial with little or no systemic absorption after oral administration and narrow activity spectrum against Gram-positive aerobic and anaerobic bacteria. Methods: Data on OPT-80 available from published studies, presentations at conferences and the manufacturer were collected and reviewed. Results/conclusion: The in vitro studies of OPT-80 and clinical C. difficile strains showed high activity at low concentrations. Safety and efficacy of the drug were found to be favourable. More Phase II and III clinical trials are to be completed.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Gerber M., Ackermann G. OPT-80, a macrocyclic antimicrobial agent for the treatment ofClostridium difficileinfections: a review // Expert Opinion on Investigational Drugs. 2008. Vol. 17. No. 4. pp. 547-553.
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Gerber M., Ackermann G. OPT-80, a macrocyclic antimicrobial agent for the treatment ofClostridium difficileinfections: a review // Expert Opinion on Investigational Drugs. 2008. Vol. 17. No. 4. pp. 547-553.
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TY - JOUR
DO - 10.1517/13543784.17.4.547
UR - https://doi.org/10.1517%2F13543784.17.4.547
TI - OPT-80, a macrocyclic antimicrobial agent for the treatment ofClostridium difficileinfections: a review
T2 - Expert Opinion on Investigational Drugs
AU - Gerber, M
AU - Ackermann, G
PY - 2008
DA - 2008/03/25 00:00:00
PB - Taylor & Francis
SP - 547-553
IS - 4
VL - 17
SN - 1354-3784
SN - 1744-7658
ER -
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@article{2008
author = {M Gerber and G Ackermann},
title = {OPT-80, a macrocyclic antimicrobial agent for the treatment ofClostridium difficileinfections: a review},
journal = {Expert Opinion on Investigational Drugs},
year = {2008},
volume = {17},
publisher = {Taylor & Francis},
month = {mar},
url = {https://doi.org/10.1517%2F13543784.17.4.547},
number = {4},
pages = {547--553},
doi = {10.1517/13543784.17.4.547}
}