Open Access
Genetics, volume 193, issue 4, pages 1025-1064
DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae
1
Centre National de la Recherche Scientifique UPR4301 Centre de Biophysique Moléculaire, 45071 Orléans Cedex 02, France
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2
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710
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Publication type: Journal Article
Publication date: 2013-04-01
PubMed ID:
23547164
Genetics
Abstract
DNA repair mechanisms are critical for maintaining the integrity of genomic DNA, and their loss is associated with cancer predisposition syndromes. Studies in Saccharomyces cerevisiae have played a central role in elucidating the highly conserved mechanisms that promote eukaryotic genome stability. This review will focus on repair mechanisms that involve excision of a single strand from duplex DNA with the intact, complementary strand serving as a template to fill the resulting gap. These mechanisms are of two general types: those that remove damage from DNA and those that repair errors made during DNA synthesis. The major DNA-damage repair pathways are base excision repair and nucleotide excision repair, which, in the most simple terms, are distinguished by the extent of single-strand DNA removed together with the lesion. Mistakes made by DNA polymerases are corrected by the mismatch repair pathway, which also corrects mismatches generated when single strands of non-identical duplexes are exchanged during homologous recombination. In addition to the true repair pathways, the postreplication repair pathway allows lesions or structural aberrations that block replicative DNA polymerases to be tolerated. There are two bypass mechanisms: an error-free mechanism that involves a switch to an undamaged template for synthesis past the lesion and an error-prone mechanism that utilizes specialized translesion synthesis DNA polymerases to directly synthesize DNA across the lesion. A high level of functional redundancy exists among the pathways that deal with lesions, which minimizes the detrimental effects of endogenous and exogenous DNA damage.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Boiteux S., Jinks-Robertson S. DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae // Genetics. 2013. Vol. 193. No. 4. pp. 1025-1064.
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Boiteux S., Jinks-Robertson S. DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae // Genetics. 2013. Vol. 193. No. 4. pp. 1025-1064.
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TY - JOUR
DO - 10.1534/genetics.112.145219
UR - https://doi.org/10.1534%2Fgenetics.112.145219
TI - DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae
T2 - Genetics
AU - Boiteux, Serge
AU - Jinks-Robertson, Sue
PY - 2013
DA - 2013/04/01 00:00:00
PB - Genetics Society of America
SP - 1025-1064
IS - 4
VL - 193
PMID - 23547164
SN - 0016-6731
SN - 1943-2631
ER -
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@article{2013_Boiteux,
author = {Serge Boiteux and Sue Jinks-Robertson},
title = {DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae},
journal = {Genetics},
year = {2013},
volume = {193},
publisher = {Genetics Society of America},
month = {apr},
url = {https://doi.org/10.1534%2Fgenetics.112.145219},
number = {4},
pages = {1025--1064},
doi = {10.1534/genetics.112.145219}
}
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MLA
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Boiteux, Serge, and Sue Jinks-Robertson. “DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae.” Genetics, vol. 193, no. 4, Apr. 2013, pp. 1025-1064. https://doi.org/10.1534%2Fgenetics.112.145219.