Radiation Research, volume 183, issue 1, pages 64-71
Radioprotective Effects of Mitochondria-Targeted Antioxidant SkQR1
Publication type: Journal Article
Publication date: 2015-01-01
Journal:
Radiation Research
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 3.4
ISSN: 00337587, 19385404
Biophysics
Radiation
Radiology Nuclear Medicine and imaging
Abstract
We show here that mitochondria-targeted antioxidant composed of plastoquinone conjugated through hydrocarbon linker with cationic rhodamine 19 (SkQR1) protected against nuclear DNA damage induced by gamma radiation in K562 erythroleukemia cells. We also demonstrate that SkQR1 prevented the early (1 h postirradiation) accumulation of phosphorylated histone H2AX (γ-H2AX) an indicator of DNA double-strand break formation, as well as the radiation-induced increase in chromosomal aberrations. These data suggested that nuclear DNA damage induced by gamma radiation may be mediated by mitochondrial reactive oxygen species (ROS) production. We show that SkQR1 suppressed delayed accumulation of ROS 32 h after irradiation probably by inhibiting mitochondrial ROS-induced ROS release mechanisms. This suggests that mitochondria-targeted antioxidants may protect cells from the late consequences of radiation exposure related to delayed oxidative stress. We have previously reported that SkQRl is the substrate of multidrug resistance pump P-glycoproten (Pgp 170) and selectively protects Pgp 170-negative cells against oxidative stress. In line with this finding, we demonstrate here that SkQR1 did not protect Pgp170-positive K562 subline against DNA damage induced by gamma radiation. The selective radioprotection of normal Pgp 170-negative cells by mitochondria-targeted antioxidants could be a promising strategy to increase the efficiency of radiotherapy for multidrug-resistant tumors.
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Citations by publishers
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Wiley
1 publication, 4.76%
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1
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4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Cherepanynets V. D. et al. Radioprotective Effects of Mitochondria-Targeted Antioxidant SkQR1 // Radiation Research. 2015. Vol. 183. No. 1. pp. 64-71.
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Cherepanynets V. D., Kireev I. I., Kireev R. I., Fetisova E. K., Antoschina M. M., Izumov D. S., Lyamzaev K. G., Riabchenko N. I., CHERNYAK B. V., Skulachev V. P. Radioprotective Effects of Mitochondria-Targeted Antioxidant SkQR1 // Radiation Research. 2015. Vol. 183. No. 1. pp. 64-71.
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TY - JOUR
DO - 10.1667/RR13708.1
UR - https://doi.org/10.1667%2FRR13708.1
TI - Radioprotective Effects of Mitochondria-Targeted Antioxidant SkQR1
T2 - Radiation Research
AU - Cherepanynets, Varvara D
AU - Kireev, Igor I
AU - Kireev, Roman I
AU - Fetisova, Elena K
AU - Antoschina, Margarita M
AU - Izumov, Denis S
AU - Lyamzaev, Konstantin G
AU - Riabchenko, Nikolay I
AU - CHERNYAK, Boris V.
AU - Skulachev, Vladimir P.
PY - 2015
DA - 2015/01/01 00:00:00
PB - Radiation Research Society
SP - 64-71
IS - 1
VL - 183
SN - 0033-7587
SN - 1938-5404
ER -
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@article{2015_Cherepanynets,
author = {Varvara D Cherepanynets and Igor I Kireev and Roman I Kireev and Elena K Fetisova and Margarita M Antoschina and Denis S Izumov and Konstantin G Lyamzaev and Nikolay I Riabchenko and Boris V. CHERNYAK and Vladimir P. Skulachev},
title = {Radioprotective Effects of Mitochondria-Targeted Antioxidant SkQR1},
journal = {Radiation Research},
year = {2015},
volume = {183},
publisher = {Radiation Research Society},
month = {jan},
url = {https://doi.org/10.1667%2FRR13708.1},
number = {1},
pages = {64--71},
doi = {10.1667/RR13708.1}
}
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MLA
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Cherepanynets, Varvara D., et al. “Radioprotective Effects of Mitochondria-Targeted Antioxidant SkQR1.” Radiation Research, vol. 183, no. 1, Jan. 2015, pp. 64-71. https://doi.org/10.1667%2FRR13708.1.