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Sovremennye Tehnologii v Medicine, volume 11, issue 1, pages 16-28

Changes in theta and gamma network oscillations during the development of neurodegenerative disorders

Kichigina V F
Publication typeJournal Article
Publication date2019-01-01
Quartile SCImago
Q4
Quartile WOS
Impact factor0.6
ISSN20764243
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
Theta and gamma oscillations registered in the hippocampus and neocortex are necessary for cognitive processes in the brain; their alterations are revealed in many neurological and psychiatric diseases. The most common forms of neurodegenerative disorders, Alzheimer’s disease (AD) and temporal lobe epilepsy (TLE) are characterized by the loss of cells and progressive violations of cognitive functions, such as memory. Early diagnosis of diseases is very important for their successful treatment. Many efforts have been done for defining early signs of these diseases. Significant advances have been made in the searching of some AD and TLE reliable biomarkers with using biochemical and imaging approaches. However, there is a great need for the biomarkers that would reflect changes of brain activity within few milliseconds to obtain information about cognitive disturbances. In the present review, the data of recent literature specifying that the coherent analysis of the theta and gamma oscillations can be used in early diagnostics of TLE and AD are considered. These data show that in a brain with the developing neurodegenerative disorder the specific violations of the theta and gamma interaction are observed. We summarize here the data on the alterations of the theta and gamma coherence based on examples from TLE and AD and from models of these diseases. The specific disturbances in interactions of theta–gamma oscillations in hippocampal, hippocampal–entorhinal, hippocampal–prefrontal, and hippocampal–septal networks were revealed in the epileptic brain. In the AD models, marked changes were observed in the theta–gamma coupling in the subiculum, an output region of the hippocampus. In addition, a decreased theta–gamma interaction between the hippocampus and the parietal cortex as well as between the hippocampus and the prefrontal cortex was also shown.

Citations by journals

1
Annals of Clinical and Experimental Neurology, 1, 100%
Annals of Clinical and Experimental Neurology
1 publication, 100%
1

Citations by publishers

1
Sovero Press Publishing House, 1, 100%
Sovero Press Publishing House
1 publication, 100%
1
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Kichigina V. F. Changes in theta and gamma network oscillations during the development of neurodegenerative disorders // Sovremennye Tehnologii v Medicine. 2019. Vol. 11. No. 1. pp. 16-28.
GOST all authors (up to 50) Copy
Kichigina V. F. Changes in theta and gamma network oscillations during the development of neurodegenerative disorders // Sovremennye Tehnologii v Medicine. 2019. Vol. 11. No. 1. pp. 16-28.
RIS |
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RIS Copy
TY - JOUR
DO - 10.17691/stm2019.11.1.02
UR - https://doi.org/10.17691%2Fstm2019.11.1.02
TI - Changes in theta and gamma network oscillations during the development of neurodegenerative disorders
T2 - Sovremennye Tehnologii v Medicine
AU - Kichigina, V F
PY - 2019
DA - 2019/01/01 00:00:00
PB - Nizhny Novgorod State Medical Academy of the Ministry of Health of the Russian Federation
SP - 16-28
IS - 1
VL - 11
SN - 2076-4243
ER -
BibTex |
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BibTex Copy
@article{2019_Kichigina
author = {V F Kichigina},
title = {Changes in theta and gamma network oscillations during the development of neurodegenerative disorders},
journal = {Sovremennye Tehnologii v Medicine},
year = {2019},
volume = {11},
publisher = {Nizhny Novgorod State Medical Academy of the Ministry of Health of the Russian Federation},
month = {jan},
url = {https://doi.org/10.17691%2Fstm2019.11.1.02},
number = {1},
pages = {16--28},
doi = {10.17691/stm2019.11.1.02}
}
MLA
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MLA Copy
Kichigina, V. F.. “Changes in theta and gamma network oscillations during the development of neurodegenerative disorders.” Sovremennye Tehnologii v Medicine, vol. 11, no. 1, Jan. 2019, pp. 16-28. https://doi.org/10.17691%2Fstm2019.11.1.02.
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