Open Access
Open access
Aging, volume 11, issue 20, pages 9111-9127

Long noncoding RNA HULC promotes hepatocellular carcinoma progression

Zhang Hongwei 1, 2
Liao Zhibin 1, 2
Furong Liu 1, 2
Chen Su 1, 2
Zhu He 1, 2
Li Yani 1, 2
Tao Ran 1, 2
Liang Huifang 1, 2
Zhang Binhao 1, 2
Zhang Xue-Wu 1, 2
Publication typeJournal Article
Publication date2019-10-23
Journal: Aging
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor5.2
ISSN19454589
Cell Biology
Aging
Abstract
Long noncoding RNAs (lncRNAs) are overexpressed in many types of cancers, suggesting they may promote tumorigenesis. The lncRNA highly upregulated in liver cancer (HULC) promotes hepatocellular carcinoma (HCC) by mechanisms that are not fully understood. In the present study, we showed that HULC is overexpressed in HCC tissues, which correlates with an unfavorable prognosis in HCC patients. We also found that HULC promotes the proliferation, migration, and invasion of HCC cells in vitro, and xenograft tumor growth in vivo. Our mechanistic studies showed that HULC works as a competing endogenous RNA for miR-2052, and that the MET receptor tyrosine kinase is a downstream target of miR-2052 in HCC. Furthermore, HULC inhibits miR-2052, thereby stimulating MET expression in HCC. Finally, MET overexpression reverses the effects of HULC depletion. In sum, our findings reveal a novel regulatory signaling cascade, the HULC/miR-2052/MET axis, which could potentially be exploited for therapeutic benefits in the treatment of HCC.

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GOST |
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GOST Copy
Zhang H. et al. Long noncoding RNA HULC promotes hepatocellular carcinoma progression // Aging. 2019. Vol. 11. No. 20. pp. 9111-9127.
GOST all authors (up to 50) Copy
Zhang H., Liao Z., Furong L., Chen S., Zhu H., Li Y., Tao R., Liang H., Zhang B., Zhang X. Long noncoding RNA HULC promotes hepatocellular carcinoma progression // Aging. 2019. Vol. 11. No. 20. pp. 9111-9127.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.18632/aging.102378
UR - https://doi.org/10.18632%2Faging.102378
TI - Long noncoding RNA HULC promotes hepatocellular carcinoma progression
T2 - Aging
AU - Zhang, Hongwei
AU - Liao, Zhibin
AU - Furong, Liu
AU - Chen, Su
AU - Zhu, He
AU - Li, Yani
AU - Tao, Ran
AU - Liang, Huifang
AU - Zhang, Binhao
AU - Zhang, Xue-Wu
PY - 2019
DA - 2019/10/23 00:00:00
PB - Impact Journals
SP - 9111-9127
IS - 20
VL - 11
PMID - 31645479
SN - 1945-4589
ER -
BibTex |
Cite this
BibTex Copy
@article{2019_Zhang
author = {Hongwei Zhang and Zhibin Liao and Liu Furong and Su Chen and He Zhu and Yani Li and Ran Tao and Huifang Liang and Binhao Zhang and Xue-Wu Zhang},
title = {Long noncoding RNA HULC promotes hepatocellular carcinoma progression},
journal = {Aging},
year = {2019},
volume = {11},
publisher = {Impact Journals},
month = {oct},
url = {https://doi.org/10.18632%2Faging.102378},
number = {20},
pages = {9111--9127},
doi = {10.18632/aging.102378}
}
MLA
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MLA Copy
Zhang, Hongwei, et al. “Long noncoding RNA HULC promotes hepatocellular carcinoma progression.” Aging, vol. 11, no. 20, Oct. 2019, pp. 9111-9127. https://doi.org/10.18632%2Faging.102378.
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