Open Access
Cancer Biology and Medicine, volume 15, issue 4, pages 375
Human epidermal growth factor receptor targeted inhibitors for the treatment of ovarian cancer
Publication type: Journal Article
Publication date: 2018-02-27
Journal:
Cancer Biology and Medicine
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 5.5
ISSN: 20953941, 09288945
PubMed ID:
30766749
Abstract
Ovarian cancer is the second most lethal gynecological cancer worldwide and while most patients respond to initial therapy, they often relapse with resistant disease. Human epidermal growth factor receptors (especially HER1/EGFR and HER2/ERBB2) are involved in disease progression; hence, strategies to inhibit their action could prove advantageous in ovarian cancer patients, especially in patients resistant to first line therapy. Monoclonal antibodies and tyrosine kinase inhibitors are two classes of drugs that act on these receptors. They have demonstrated valuable antitumor activity in multiple cancers and their possible use in ovarian cancer continues to be studied. In this review, we discuss the human epidermal growth factor receptor family; review emerging clinical studies on monoclonal antibodies and tyrosine kinase inhibitors targeting these receptors in ovarian cancer patients; and propose future research possibilities in this area.
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1
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1 publication, 4.76%
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1 publication, 4.76%
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1 publication, 4.76%
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1
2
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Citations by publishers
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2
4
6
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10
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Multidisciplinary Digital Publishing Institute (MDPI)
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10 publications, 47.62%
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3 publications, 14.29%
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1 publication, 4.76%
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1 publication, 4.76%
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Wolters Kluwer Health
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1 publication, 4.76%
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Public Library of Science (PLoS)
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1 publication, 4.76%
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Elsevier
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Elsevier
1 publication, 4.76%
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Wiley
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Wiley
1 publication, 4.76%
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Taylor & Francis
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Taylor & Francis
1 publication, 4.76%
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2
4
6
8
10
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Maria B., Andrew H.S., Simon P.L. Human epidermal growth factor receptor targeted inhibitors for the treatment of ovarian cancer // Cancer Biology and Medicine. 2018. Vol. 15. No. 4. p. 375.
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Maria B., Andrew H.S., Simon P.L. Human epidermal growth factor receptor targeted inhibitors for the treatment of ovarian cancer // Cancer Biology and Medicine. 2018. Vol. 15. No. 4. p. 375.
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TY - JOUR
DO - 10.20892/j.issn.2095-3941.2018.0062
UR - https://doi.org/10.20892%2Fj.issn.2095-3941.2018.0062
TI - Human epidermal growth factor receptor targeted inhibitors for the treatment of ovarian cancer
T2 - Cancer Biology and Medicine
AU - Maria, B
AU - Andrew, H S
AU - Simon, P L
PY - 2018
DA - 2018/02/27 00:00:00
PB - Chinese Anticancer Association
SP - 375
IS - 4
VL - 15
PMID - 30766749
SN - 2095-3941
SN - 0928-8945
ER -
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@article{2018,
author = {B Maria and H S Andrew and P L Simon},
title = {Human epidermal growth factor receptor targeted inhibitors for the treatment of ovarian cancer},
journal = {Cancer Biology and Medicine},
year = {2018},
volume = {15},
publisher = {Chinese Anticancer Association},
month = {feb},
url = {https://doi.org/10.20892%2Fj.issn.2095-3941.2018.0062},
number = {4},
pages = {375},
doi = {10.20892/j.issn.2095-3941.2018.0062}
}