Mini-Reviews in Medicinal Chemistry, volume 16, issue 8, pages 630-643
Carbazole derivatives: a promising scenario for breast cancer treatment
Publication type: Journal Article
Publication date: 2016-01-22
Journal:
Mini-Reviews in Medicinal Chemistry
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3.8
ISSN: 13895575
Drug Discovery
General Medicine
Pharmacology
Abstract
Chemotherapeutics used in cancer treatment may elicit pleiotropic effects interfering, for instance, directly on DNA metabolism or on endoplasmic organelles functions. Recently there has been a trend towards the use of molecular-targeted therapies as alternative treatments of cancer, arising from the need to overcome the onset of undesired side effects or drug-resistance. Thus, a major challenge is the design and synthesis of new agents able to interact with specific cellular components, often over-expressed or altered in cancerous cells, such as telomerase and topoisomerase or protein kinases, with reduced toxicity at effective doses. The main molecular targets for the development of new anticancer drugs include: cell surface receptors, signal transduction pathways, enzymes, gene transcription, ubiquitin-proteasome/heat shock proteins, and anti-angiogenic agents. Several natural or synthetic polycyclic molecules with carbazolic nucleus, which show attractive drug-like properties, were identified with the aim to increase their biological activities and their specificity, obtaining cytotoxic agents effective in a panel of cancer cell lines. The cytotoxic profile of these compounds has been assessed using several in vitro assays as, for instance, MTT, colony formation, and flow cytometry assays and some of these compounds showed an interesting profile at sub-micromolar concentrations. The usefulness of some carbazole derivatives has been demonstrated, as well, in preclinical studies.
Citations by journals
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1 publication, 1.69%
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1 publication, 1.69%
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1 publication, 1.69%
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ACS Omega
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1 publication, 1.69%
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1 publication, 1.69%
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1 publication, 1.69%
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Journal of Chemical Thermodynamics
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1 publication, 1.69%
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1 publication, 1.69%
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Bioorganic and Medicinal Chemistry Letters
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1 publication, 1.69%
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European Journal of Pharmaceutical Sciences
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1 publication, 1.69%
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1 publication, 1.69%
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1 publication, 1.69%
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1 publication, 1.69%
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1 publication, 1.69%
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Journal of Inorganic Biochemistry
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Journal of Inorganic Biochemistry
1 publication, 1.69%
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Journal of Organometallic Chemistry
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Journal of Organometallic Chemistry
1 publication, 1.69%
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European Journal of Organic Chemistry
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European Journal of Organic Chemistry
1 publication, 1.69%
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Chemical Biology and Drug Design
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1 publication, 1.69%
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5
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Citations by publishers
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2
4
6
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10
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14
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Elsevier
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Elsevier
13 publications, 22.03%
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Wiley
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Wiley
13 publications, 22.03%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
11 publications, 18.64%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
5 publications, 8.47%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
5 publications, 8.47%
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Bentham Science
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4 publications, 6.78%
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Springer Nature
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Springer Nature
2 publications, 3.39%
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Taylor & Francis
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Taylor & Francis
2 publications, 3.39%
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American Society for Microbiology
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American Society for Microbiology
1 publication, 1.69%
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IOP Publishing
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IOP Publishing
1 publication, 1.69%
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KeAi Communications Co.
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KeAi Communications Co.
1 publication, 1.69%
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Hindawi Limited
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Hindawi Limited
1 publication, 1.69%
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2
4
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14
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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MLA
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GOST
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Caruso A. M. et al. Carbazole derivatives: a promising scenario for breast cancer treatment // Mini-Reviews in Medicinal Chemistry. 2016. Vol. 16. No. 8. pp. 630-643.
GOST all authors (up to 50)
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Caruso A. M., Iacopetta D., Puoci F., Cappello A. R., Saturnino C., Sinicropi M. S. Carbazole derivatives: a promising scenario for breast cancer treatment // Mini-Reviews in Medicinal Chemistry. 2016. Vol. 16. No. 8. pp. 630-643.
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TY - JOUR
DO - 10.2174/1389557515666150709111342
UR - https://doi.org/10.2174%2F1389557515666150709111342
TI - Carbazole derivatives: a promising scenario for breast cancer treatment
T2 - Mini-Reviews in Medicinal Chemistry
AU - Caruso, Anna Maria
AU - Iacopetta, Domenico
AU - Puoci, Francesco
AU - Cappello, Anna Rita
AU - Saturnino, Carmela
AU - Sinicropi, Maria Stefania
PY - 2016
DA - 2016/01/22 00:00:00
PB - Bentham Science
SP - 630-643
IS - 8
VL - 16
SN - 1389-5575
ER -
Cite this
BibTex
Copy
@article{2016_Caruso,
author = {Anna Maria Caruso and Domenico Iacopetta and Francesco Puoci and Anna Rita Cappello and Carmela Saturnino and Maria Stefania Sinicropi},
title = {Carbazole derivatives: a promising scenario for breast cancer treatment},
journal = {Mini-Reviews in Medicinal Chemistry},
year = {2016},
volume = {16},
publisher = {Bentham Science},
month = {jan},
url = {https://doi.org/10.2174%2F1389557515666150709111342},
number = {8},
pages = {630--643},
doi = {10.2174/1389557515666150709111342}
}
Cite this
MLA
Copy
Caruso, Anna Maria, et al. “Carbazole derivatives: a promising scenario for breast cancer treatment.” Mini-Reviews in Medicinal Chemistry, vol. 16, no. 8, Jan. 2016, pp. 630-643. https://doi.org/10.2174%2F1389557515666150709111342.