Current Topics in Medicinal Chemistry, volume 16, issue 11, pages 1290-1313
Carbazole Scaffold in Medicinal Chemistry and Natural Products: A Review from 2010-2015
1
Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Dr., Hilo, HI 96720, USA.
|
Publication type: Journal Article
Publication date: 2016-03-03
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 3.4
ISSN: 15680266, 18734294
Drug Discovery
General Medicine
Abstract
9H-carbazole is an aromatic molecule that is tricyclic in nature, with two benzene rings fused onto a 5-membered pyrrole ring. Obtained from natural sources or by synthetic routes, this scaffold has gained much interest due to its wide range of biological activity upon modifications, including antibacterial, antimalarial, anticancer, and anti-Alzheimer properties. This review reports a survey of the literature on carbazole-containing molecules and their medicinal activities from 2010 through 2015. In particular, we focus on their in vitro and in vivo activities and summarize structure-activity relationships (SAR), mechanisms of action, and/or cytotoxicity/selectivity findings when available to provide future guidance for the development of clinically useful agents from this template.
Citations by journals
|
1
2
3
4
|
|
|
European Journal of Medicinal Chemistry
|
European Journal of Medicinal Chemistry
4 publications, 4.88%
|
|
Advanced Synthesis and Catalysis
|
Advanced Synthesis and Catalysis
4 publications, 4.88%
|
|
Journal of Heterocyclic Chemistry
|
Journal of Heterocyclic Chemistry
3 publications, 3.66%
|
|
European Journal of Organic Chemistry
|
European Journal of Organic Chemistry
3 publications, 3.66%
|
|
Chemistry - A European Journal
|
Chemistry - A European Journal
3 publications, 3.66%
|
|
Organic Letters
|
Organic Letters
3 publications, 3.66%
|
|
Journal of Organic Chemistry
|
Journal of Organic Chemistry
3 publications, 3.66%
|
|
Organic Chemistry Frontiers
|
Organic Chemistry Frontiers
3 publications, 3.66%
|
|
Molecules
|
Molecules
2 publications, 2.44%
|
|
Medicinal Chemistry Research
|
Medicinal Chemistry Research
2 publications, 2.44%
|
|
Tetrahedron
|
Tetrahedron
2 publications, 2.44%
|
|
ChemistrySelect
|
ChemistrySelect
2 publications, 2.44%
|
|
Organic and Biomolecular Chemistry
|
Organic and Biomolecular Chemistry
2 publications, 2.44%
|
|
Chemical Communications
|
Chemical Communications
2 publications, 2.44%
|
|
Advances in Heterocyclic Chemistry
|
Advances in Heterocyclic Chemistry
2 publications, 2.44%
|
|
Anti-Infective Agents
|
Anti-Infective Agents
1 publication, 1.22%
|
|
Current Traditional Medicine
|
Current Traditional Medicine
1 publication, 1.22%
|
|
Letters in Drug Design and Discovery
|
Letters in Drug Design and Discovery
1 publication, 1.22%
|
|
Oxidative Medicine and Cellular Longevity
|
Oxidative Medicine and Cellular Longevity
1 publication, 1.22%
|
|
Biomolecules
|
Biomolecules
1 publication, 1.22%
|
|
Chemical Research in Chinese Universities
|
Chemical Research in Chinese Universities
1 publication, 1.22%
|
|
Journal of Molecular Structure
|
Journal of Molecular Structure
1 publication, 1.22%
|
|
Tetrahedron Letters
|
Tetrahedron Letters
1 publication, 1.22%
|
|
Bioorganic Chemistry
|
Bioorganic Chemistry
1 publication, 1.22%
|
|
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
|
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
1 publication, 1.22%
|
|
European Journal of Pharmaceutical Sciences
|
European Journal of Pharmaceutical Sciences
1 publication, 1.22%
|
|
Coordination Chemistry Reviews
|
Coordination Chemistry Reviews
1 publication, 1.22%
|
|
Dyes and Pigments
|
Dyes and Pigments
1 publication, 1.22%
|
|
Bioorganic and Medicinal Chemistry Letters
|
Bioorganic and Medicinal Chemistry Letters
1 publication, 1.22%
|
|
Journal of Inorganic Biochemistry
|
Journal of Inorganic Biochemistry
1 publication, 1.22%
|
|
1
2
3
4
|
Citations by publishers
|
5
10
15
20
25
|
|
|
Wiley
|
Wiley
23 publications, 28.05%
|
|
Elsevier
|
Elsevier
20 publications, 24.39%
|
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
10 publications, 12.2%
|
|
Royal Society of Chemistry (RSC)
|
Royal Society of Chemistry (RSC)
10 publications, 12.2%
|
|
Taylor & Francis
|
Taylor & Francis
5 publications, 6.1%
|
|
Springer Nature
|
Springer Nature
4 publications, 4.88%
|
|
Bentham Science
|
Bentham Science
3 publications, 3.66%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 3.66%
|
|
Hindawi Limited
|
Hindawi Limited
1 publication, 1.22%
|
|
Dove Medical Press
|
Dove Medical Press
1 publication, 1.22%
|
|
Thieme
|
Thieme
1 publication, 1.22%
|
|
5
10
15
20
25
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","","",""],"datasets":[{"label":"Citations number","data":[1,8,14,12,12,11,10,9,5],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["1.22","9.76","17.07","14.63","14.63","13.41","12.2","10.98","6.1"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["European Journal of Medicinal Chemistry","Advanced Synthesis and Catalysis","Journal of Heterocyclic Chemistry","European Journal of Organic Chemistry","Chemistry - A European Journal","Organic Letters","Journal of Organic Chemistry","Organic Chemistry Frontiers","Molecules","Medicinal Chemistry Research","Tetrahedron","ChemistrySelect","Organic and Biomolecular Chemistry","Chemical Communications","Advances in Heterocyclic Chemistry","Anti-Infective Agents","Current Traditional Medicine","Letters in Drug Design and Discovery","Oxidative Medicine and Cellular Longevity","Biomolecules","Chemical Research in Chinese Universities","Journal of Molecular Structure","Tetrahedron Letters","Bioorganic Chemistry","Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy","European Journal of Pharmaceutical Sciences","Coordination Chemistry Reviews","Dyes and Pigments","Bioorganic and Medicinal Chemistry Letters","Journal of Inorganic Biochemistry"],"ids":[8171,3906,3189,19472,24708,3315,8697,3991,1770,6106,3439,8021,541,9073,7227,20038,33513,7124,11615,13780,1401,9347,6133,4196,6337,9338,13437,10101,8828,6830],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/hqfzhQAjTGlNSRs6yzFNITgjSMm9Jr2QuotJHIvE_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[4,4,3,3,3,3,3,3,2,2,2,2,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[4.88,4.88,3.66,3.66,3.66,3.66,3.66,3.66,2.44,2.44,2.44,2.44,2.44,2.44,2.44,1.22,1.22,1.22,1.22,1.22,1.22,1.22,1.22,1.22,1.22,1.22,1.22,1.22,1.22,1.22],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Wiley","Elsevier","American Chemical Society (ACS)","Royal Society of Chemistry (RSC)","Taylor & Francis","Springer Nature","Bentham Science","Multidisciplinary Digital Publishing Institute (MDPI)","Hindawi Limited","Dove Medical Press","Thieme"],"ids":[11,17,40,123,18,8,39,202,6921,417,135],"codes":[0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/hqfzhQAjTGlNSRs6yzFNITgjSMm9Jr2QuotJHIvE_medium.webp","\/storage\/images\/resized\/wVWp6zaxUsMdR03dYMdOZoesUrVGtNMWkHKByIvT_medium.webp","\/storage\/images\/resized\/xqixcltwJYe6H8Uco2JbAFfIOzt7UNKH0OcPOPzO_medium.webp"],"datasets":[{"label":"","data":[23,20,10,10,5,4,3,3,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[28.05,24.39,12.2,12.2,6.1,4.88,3.66,3.66,1.22,1.22,1.22],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
S. Tsutsumi L., Gündisch D., Sun D. Carbazole Scaffold in Medicinal Chemistry and Natural Products: A Review from 2010-2015 // Current Topics in Medicinal Chemistry. 2016. Vol. 16. No. 11. pp. 1290-1313.
GOST all authors (up to 50)
Copy
S. Tsutsumi L., Gündisch D., Sun D. Carbazole Scaffold in Medicinal Chemistry and Natural Products: A Review from 2010-2015 // Current Topics in Medicinal Chemistry. 2016. Vol. 16. No. 11. pp. 1290-1313.
Cite this
RIS
Copy
TY - JOUR
DO - 10.2174/1568026615666150915112647
UR - https://doi.org/10.2174%2F1568026615666150915112647
TI - Carbazole Scaffold in Medicinal Chemistry and Natural Products: A Review from 2010-2015
T2 - Current Topics in Medicinal Chemistry
AU - S. Tsutsumi, Lissa
AU - Gündisch, Daniela
AU - Sun, Dianqing
PY - 2016
DA - 2016/03/03 00:00:00
PB - Bentham Science
SP - 1290-1313
IS - 11
VL - 16
SN - 1568-0266
SN - 1873-4294
ER -
Cite this
BibTex
Copy
@article{2016_S. Tsutsumi,
author = {Lissa S. Tsutsumi and Daniela Gündisch and Dianqing Sun},
title = {Carbazole Scaffold in Medicinal Chemistry and Natural Products: A Review from 2010-2015},
journal = {Current Topics in Medicinal Chemistry},
year = {2016},
volume = {16},
publisher = {Bentham Science},
month = {mar},
url = {https://doi.org/10.2174%2F1568026615666150915112647},
number = {11},
pages = {1290--1313},
doi = {10.2174/1568026615666150915112647}
}
Cite this
MLA
Copy
S. Tsutsumi, Lissa, et al. “Carbazole Scaffold in Medicinal Chemistry and Natural Products: A Review from 2010-2015.” Current Topics in Medicinal Chemistry, vol. 16, no. 11, Mar. 2016, pp. 1290-1313. https://doi.org/10.2174%2F1568026615666150915112647.