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Bulletin of Russian State Medical University, issue 3, pages 35-43

Changes in plasma sphingolipid levels against the background of lipid-lowering therapy in patients with premature atherosclerosis

Publication typeJournal Article
Publication date2021-06-24
Quartile SCImago
Q4
Quartile WOS
Impact factor0.2
ISSN25001094, 25421204
General Medicine
Abstract

Lipid-lowering drugs affect standard lipoproteins. However, we have no knowledge of changes in other plasma lipids upon treatment. The study was aimed to assess the dynamic changes in cholesterol, high- and low-density lipoproteins (HDL and LDL), triglycerides, and sphingolipids against the background of lipidlowering therapy in patients with premature coronary artery disease, atherosclerosis and hypercholesterolemia. A total of 18 patients were enrolled (the average age was 53 ± 6.7 years): in group 1, six patients received starting statin doses; group 2 included six patients, who failed to achieve LDL target levels against the background of treatment with starting statin doses, and received escalated statin doses; seven patients in group 3 failed to achieve LDL target levels against the background of treatment with maximum tolerated doses of statins and ezetimibe, and received alirocumab. Sphingolipid levels were assessed by mass spectrometry. In group 1, the decreased levels of ceramide Cer 14:1 (p = 0.046) and sphingomyelins SM 22:1, SM 22:0, SM 24:0 (p = 0.028) were observed. There were no significant changes in the levels of total cholesterol, LDL-C, HDL-C, and triglycerides. In group 2, the significantly decreased levels of total cholesterol (p = 0.028), LDL (p = 0.043), sphingomyelins SM 18:1, SM 24:1 and SM 26:1, and ceramide Cer 16:1 (p = 0.028) were observed. The level of Cer 22:1 significantly increased (p = 0.028). In group 3, total cholesterol decreased by 36.2%, and LDL-C (p = 0.018) decreased by 60.1% compared to baseline (ΔLDL-C = –2.67 ± 3.12); the elevated levels of ceramide Cer 22:1 (p = 0.028) were observed. It has been shown, that decreased sphingomyelin levels are associated with statin therapy and correlate with decreased levels of LDL-C. No significant dynamic changes in ceramides and ceramide risk against the background of statin therapy were observed, however, PCSK9 inhibitor added to therapy reduced the Cer 16:0/24:0 ratio.

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Rogozhina A. et al. Changes in plasma sphingolipid levels against the background of lipid-lowering therapy in patients with premature atherosclerosis // Bulletin of Russian State Medical University. 2021. Vol. 3. pp. 35-43.
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Rogozhina A., Alessenko A. V., Kurochkin I., Minushkina L., Gutner U., Shupik M. A., Maloshitskaya O., Lebedev A., Zateyshchikov D. Changes in plasma sphingolipid levels against the background of lipid-lowering therapy in patients with premature atherosclerosis // Bulletin of Russian State Medical University. 2021. Vol. 3. pp. 35-43.
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TY - JOUR
DO - 10.24075/BRSMU.2021.030
UR - https://doi.org/10.24075%2FBRSMU.2021.030
TI - Changes in plasma sphingolipid levels against the background of lipid-lowering therapy in patients with premature atherosclerosis
T2 - Bulletin of Russian State Medical University
AU - Rogozhina, Aa
AU - Alessenko, A. V.
AU - Kurochkin, In
AU - Minushkina, Larisa
AU - Gutner, Ua
AU - Shupik, M. A.
AU - Maloshitskaya, Oa
AU - Lebedev, AT
AU - Zateyshchikov, D.
PY - 2021
DA - 2021/06/24 00:00:00
PB - Pirogov Russian National Research Medical University
SP - 35-43
IS - 3
SN - 2500-1094
SN - 2542-1204
ER -
BibTex
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@article{2021_Rogozhina
author = {Aa Rogozhina and A. V. Alessenko and In Kurochkin and Larisa Minushkina and Ua Gutner and M. A. Shupik and Oa Maloshitskaya and AT Lebedev and D. Zateyshchikov},
title = {Changes in plasma sphingolipid levels against the background of lipid-lowering therapy in patients with premature atherosclerosis},
journal = {Bulletin of Russian State Medical University},
year = {2021},
publisher = {Pirogov Russian National Research Medical University},
month = {jun},
url = {https://doi.org/10.24075%2FBRSMU.2021.030},
number = {3},
pages = {35--43},
doi = {10.24075/BRSMU.2021.030}
}
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