Bulletin of Russian State Medical University, issue 2020(5)

Prospective pharmacological effects of psoralen photoxidation products and their cycloadducts with aminothiols: chemoinformatic analysis

Skarga Vv ¹

Zadorozhny Ad ²

Shilov Bv ²

Nevezhin Ev ²

Negrebetsky Vadim V. ²

Maslov Michael ³

Лагунин А.А. ⁴

Malakhov Mv ²

Hide authors affiliations Show authors affiliations: 4 affiliations

Pirogov Russian National Research Medical University, Moscow, Russia; MIREA — Russian Technological University, Moscow, Russia

MIREA — Russian Technological University

Pirogov Russian National Research Medical University

Pirogov Russian National Research Medical University, Moscow, Russia |

MIREA — Russian Technological University, Moscow, Russia |

⁴

Pirogov Russian National Research Medical University, Moscow, Russia; Institute of Biomedical Chemistry (IBMC), Moscow, Russia

V. N. Orekhovich Research Institute of Biomedical Chemistry

Pirogov Russian National Research Medical University

Publication type: Journal Article

Publication date: 2020-10-12

Pirogov Russian National Research Medical University

Journal: Bulletin of Russian State Medical University

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Impact factor: 0.2

ISSN: 25001094, 25421204

DOI: 10.24075/brsmu.2020.059

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General Medicine

Abstract

Psoralens are medicinal photosensitizing furocoumarins which are used in photochemotherapy and photoimmunotherapy of dermatoses. Psoralen photooxidation products may be involved in therapeutic effects, but the possible mechanisms of their action remain unclear. The study was aimed to assess the prospective pharmacological effects and mechanisms of activity for six previously identified ortho–hydroxyformyl-containing psoralen photooxidation products and their cycloadducts with aminothiols, as well as for structurally similar compounds (furocoumaric acid and tucaresol). Chemoinformatic analysis of the prospective pharmacological effects and mechanisms of action of these compounds was performed using the PASS and PharmaExpert software. The predicted pharmacological effects partially confirmed by previous studies highlight the possible involvement of psoralen photooxidation products in the effects of PUVA therapy or photopheresis during the course of dermatoses and proliferative disorders treatment. A broad spectrum of pharmacological effects found for furocoumaric acid and cycloadducts of coumarinic and benzofuranic photoproducts of psoralen with cysteine and homocysteine appoints new directions of research relating to therapeutic use of psoralens.

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Skarga V. et al. Prospective pharmacological effects of psoralen photoxidation products and their cycloadducts with aminothiols: chemoinformatic analysis // Bulletin of Russian State Medical University. 2020. Vol. 2020(5).

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Skarga V., Zadorozhny A., Shilov B., Nevezhin E., Negrebetsky V. V., Maslov M., Лагунин А., Malakhov M. Prospective pharmacological effects of psoralen photoxidation products and their cycloadducts with aminothiols: chemoinformatic analysis // Bulletin of Russian State Medical University. 2020. Vol. 2020(5).

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RIS Copy

TY - JOUR

DO - 10.24075/brsmu.2020.059

UR - https://doi.org/10.24075%2Fbrsmu.2020.059

TI - Prospective pharmacological effects of psoralen photoxidation products and their cycloadducts with aminothiols: chemoinformatic analysis

T2 - Bulletin of Russian State Medical University

AU - Skarga, Vv

AU - Zadorozhny, Ad

AU - Shilov, Bv

AU - Nevezhin, Ev

AU - Negrebetsky, Vadim V.

AU - Maslov, Michael

AU - Лагунин, А.А.

AU - Malakhov, Mv

PY - 2020

DA - 2020/10/12 00:00:00

PB - Pirogov Russian National Research Medical University

IS - 2020(5)

SN - 2500-1094

SN - 2542-1204

ER -

BibTex

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BibTex Copy

@article{2020_Skarga,

author = {Vv Skarga and Ad Zadorozhny and Bv Shilov and Ev Nevezhin and Vadim V. Negrebetsky and Michael Maslov and А.А. Лагунин and Mv Malakhov},

title = {Prospective pharmacological effects of psoralen photoxidation products and their cycloadducts with aminothiols: chemoinformatic analysis},

journal = {Bulletin of Russian State Medical University},

year = {2020},

publisher = {Pirogov Russian National Research Medical University},

month = {oct},

url = {https://doi.org/10.24075%2Fbrsmu.2020.059},

number = {2020(5)},

doi = {10.24075/brsmu.2020.059}

}

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Publisher

Pirogov Russian National Research Medical University

Journal

Bulletin of Russian State Medical University

Quartile SCImago

Quartile WOS

—

Impact factor

0.2

ISSN

25001094 (Print)
25421204 (Electronic)

Labs

Laboratory of Lipids

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