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CLINICAL AND EXPERIMENTAL MORPHOLOGY, volume 10, issue 1, pages 58-65

Comparative morphological and biochemical characteristics of the toxic effects of doxorubicin and nanosomal plga-doxorubicin form in the experimental glioblastoma treatment

Publication type: Journal Article
Publication date: 2021-04-01
Quartile SCImago
Q4
Quartile WOS
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Impact factor: —
ISSN: 22265988, 26866749
Cancer Research
Cell Biology
Molecular Medicine
Pathology and Forensic Medicine
Abstract

Introduction. Doxorubicin (Dox) in the composition of poly(lactic-co-glycolic acid, 50:50) (PLGA) – nanoparticles has high antitumor efficacy in rats with glioblastoma 101.8. However, the toxic effect of Dox-PLGA is not well understood. The aim of the study was morphological and biochemical evaluation of the hepatotoxic and cardiotoxic effects of doxorubicin and Dox-PLGA in the glioblastoma 101.8 treat-ment in Wistar rats. Materials and methods. The study was performed on 24 male Wistar rats with glioblastoma: no treatment (n=7), treated with doxorubicin (n=9) or Dox-PLGA (n=8) intravenously at a dose of 1.5 mg/kg on days 2, 5 and 8 after tumor implantation. On the 14th day of the experiment, morphological changes in the myocardium and liver were examined. Hematological and biochemical blood tests were performed. Results.When treating rats with experimental glioblastoma 101.8, Dox-PLGA in comparison with doxorubicin has less pronounced cardiotoxic and hepatotoxic effects according to the morphological, hematological and biochemical tests. Inflammatory changes in the myocardium of the animals treated with Dox-PLGA were less pronounced and widespread than the ones treated with doxorubicin. The activities of total and cardiac creatine phosphokinase (CPK) isoforms and AST were statistically significantly lower in Dox-PLGA group than in animals with glioblastoma without treatment and receiving doxorubicin. The hepatotoxic effects of Dox-PLGA were minimal. Unlike animals treated with doxorubicin, they had mild hepatocyte dystrophy. ALT activity in all groups did not differ from the reference values. Conclusion. Compared with doxorubicin, the nanosomal form of Dox-PLGA in the experimental glioblas-toma 101.8 treatment has less pronounced cardio- and hepatotoxic effects. Keywords: rat glioblastoma 101.8, doxorubicin, PLGA-nanoparticles, toxic effect, liver, myocardium, morphology, biochemistry

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Kudelkina V. V. et al. Comparative morphological and biochemical characteristics of the toxic effects of doxorubicin and nanosomal plga-doxorubicin form in the experimental glioblastoma treatment // CLINICAL AND EXPERIMENTAL MORPHOLOGY. 2021. Vol. 10. No. 1. pp. 58-65.
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Kudelkina V. V., Khalansky A. S., Makarova O., Tsvetkov I. S., Kosyreva A., Alekseeva A. I., Shelkоv A. Y., Maksimenko O., Razzhivina V. A., Gelperina S. Comparative morphological and biochemical characteristics of the toxic effects of doxorubicin and nanosomal plga-doxorubicin form in the experimental glioblastoma treatment // CLINICAL AND EXPERIMENTAL MORPHOLOGY. 2021. Vol. 10. No. 1. pp. 58-65.
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TY - JOUR
DO - 10.31088/CEM2021.10.1.58-65
UR - https://doi.org/10.31088%2FCEM2021.10.1.58-65
TI - Comparative morphological and biochemical characteristics of the toxic effects of doxorubicin and nanosomal plga-doxorubicin form in the experimental glioblastoma treatment
T2 - CLINICAL AND EXPERIMENTAL MORPHOLOGY
AU - Kudelkina, Vera V.
AU - Khalansky, A S
AU - Makarova, O.
AU - Tsvetkov, Ivan Sergeevich
AU - Kosyreva, Anna
AU - Alekseeva, A I
AU - Shelkоv, A Y
AU - Maksimenko, Olga
AU - Razzhivina, V A
AU - Gelperina, S.E
PY - 2021
DA - 2021/04/01 00:00:00
PB - Research Institute of Human Morphology
SP - 58-65
IS - 1
VL - 10
SN - 2226-5988
SN - 2686-6749
ER -
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@article{2021_Kudelkina,
author = {Vera V. Kudelkina and A S Khalansky and O. Makarova and Ivan Sergeevich Tsvetkov and Anna Kosyreva and A I Alekseeva and A Y Shelkоv and Olga Maksimenko and V A Razzhivina and S.E Gelperina},
title = {Comparative morphological and biochemical characteristics of the toxic effects of doxorubicin and nanosomal plga-doxorubicin form in the experimental glioblastoma treatment},
journal = {CLINICAL AND EXPERIMENTAL MORPHOLOGY},
year = {2021},
volume = {10},
publisher = {Research Institute of Human Morphology},
month = {apr},
url = {https://doi.org/10.31088%2FCEM2021.10.1.58-65},
number = {1},
pages = {58--65},
doi = {10.31088/CEM2021.10.1.58-65}
}
MLA
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Kudelkina, Vera V., et al. “Comparative morphological and biochemical characteristics of the toxic effects of doxorubicin and nanosomal plga-doxorubicin form in the experimental glioblastoma treatment.” CLINICAL AND EXPERIMENTAL MORPHOLOGY, vol. 10, no. 1, Apr. 2021, pp. 58-65. https://doi.org/10.31088%2FCEM2021.10.1.58-65.
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