Open Access
Acta Naturae, volume 1, issue 3, pages 121-124
Deamination of 5-Methylcytosine Residues in Mammalian Cells
Publication type: Journal Article
Publication date: 2009-12-15
Abstract
DNA demethylation in mammalia occurs after fertilization and during embryogenesis and accompanies cell aging and cancer transformation. With the help of the primer extension reaction, MALDI MS and DNA cleavage by thymine DNA glycosylase deamination of 5-methylcytosine residues has been shown to take place when the model methylated DNA duplexes are treated with nuclear extracts from the cell lines CHO, HeLa, and Skov3. The hypothesis that deamination of 5-methylcytosine is the first stage of demethylation in mammalia has been postulated.
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Gromenko E.V. et al. Deamination of 5-Methylcytosine Residues in Mammalian Cells // Acta Naturae. 2009. Vol. 1. No. 3. pp. 121-124.
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Gromenko E.V., Spirin P.V., Kubareva E.A., Romanova E.A., Prassolov V.S., Shpanchenko O.V., Dontsova O.A. Deamination of 5-Methylcytosine Residues in Mammalian Cells // Acta Naturae. 2009. Vol. 1. No. 3. pp. 121-124.
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TY - JOUR
DO - 10.32607/20758251-2009-1-3-121-124
UR - https://doi.org/10.32607%2F20758251-2009-1-3-121-124
TI - Deamination of 5-Methylcytosine Residues in Mammalian Cells
T2 - Acta Naturae
AU - Gromenko, E V
AU - Spirin, P V
AU - Kubareva, E A
AU - Romanova, E A
AU - Prassolov, V S
AU - Shpanchenko, O V
AU - Dontsova, O A
PY - 2009
DA - 2009/12/15 00:00:00
PB - Acta Naturae Ltd
SP - 121-124
IS - 3
VL - 1
SN - 2075-8251
SN - 2075-8243
ER -
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@article{2009,
author = {E V Gromenko and P V Spirin and E A Kubareva and E A Romanova and V S Prassolov and O V Shpanchenko and O A Dontsova},
title = {Deamination of 5-Methylcytosine Residues in Mammalian Cells},
journal = {Acta Naturae},
year = {2009},
volume = {1},
publisher = {Acta Naturae Ltd},
month = {dec},
url = {https://doi.org/10.32607%2F20758251-2009-1-3-121-124},
number = {3},
pages = {121--124},
doi = {10.32607/20758251-2009-1-3-121-124}
}