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Acta Naturae, volume 14, issue 1, pages 14-30

Eukaryotic Ribosome Biogenesis: The 40S Subunit

Moraleva Anastasia A

Dontsova Olga A.

Deryabin Alexander S

Rubtsova Maria P

Rubtsov Yury P

Publication type: Journal Article

Publication date: 2022-05-10

Acta Naturae Ltd

Journal: Acta Naturae

Quartile SCImago

Quartile WOS

Impact factor: 2

ISSN: 20758251, 20758243

DOI: 10.32607/actanaturae.11540

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PubMed ID: 35441050

Abstract

The formation of eukaryotic ribosomes is a sequential process of ribosomal precursors maturation in the nucleolus, nucleoplasm, and cytoplasm. Hundreds of ribosomal biogenesis factors ensure the accurate processing and formation of the ribosomal RNAs tertiary structure, and they interact with ribosomal proteins. Most of what we know about the ribosome assembly has been derived from yeast cell studies, and the mechanisms of ribosome biogenesis in eukaryotes are considered quite conservative. Although the main stages of ribosome biogenesis are similar across different groups of eukaryotes, this process in humans is much more complicated owing to the larger size of the ribosomes and pre-ribosomes and the emergence of regulatory pathways that affect their assembly and function. Many of the factors involved in the biogenesis of human ribosomes have been identified using genome-wide screening based on RNA interference. This review addresses the key aspects of yeast and human ribosome biogenesis, using the 40S subunit as an example. The mechanisms underlying these differences are still not well understood, because, unlike yeast, there are no effective methods for characterizing pre-ribosomal complexes in humans. Understanding the mechanisms of human ribosome assembly would have an incidence on a growing number of genetic diseases (ribosomopathies) caused by mutations in the genes encoding ribosomal proteins and ribosome biogenesis factors. In addition, there is evidence that ribosome assembly is regulated by oncogenic signaling pathways, and that defects in the ribosome biogenesis are linked to the activation of tumor suppressors.

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	1
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 25% International Journal of Molecular Sciences 1 publication, 25%
Agrarian science	Agrarian science, 1, 25% Agrarian science 1 publication, 25%
Viruses	Viruses, 1, 25% Viruses 1 publication, 25%
Cells	Cells, 1, 25% Cells 1 publication, 25%
	1

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	1 2 3
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 3, 75% Multidisciplinary Digital Publishing Institute (MDPI) 3 publications, 75%
Agrarian Science	Agrarian Science, 1, 25% Agrarian Science 1 publication, 25%
	1 2 3

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Moraleva A. A. et al. Eukaryotic Ribosome Biogenesis: The 40S Subunit // Acta Naturae. 2022. Vol. 14. No. 1. pp. 14-30.

GOST all authors (up to 50) Copy

Moraleva A. A., Deryabin A. S., Rubtsova M. P., Dontsova O. A., Rubtsov Y. P. Eukaryotic Ribosome Biogenesis: The 40S Subunit // Acta Naturae. 2022. Vol. 14. No. 1. pp. 14-30.

RIS |

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RIS Copy

TY - JOUR

DO - 10.32607/actanaturae.11540

UR - https://doi.org/10.32607%2Factanaturae.11540

TI - Eukaryotic Ribosome Biogenesis: The 40S Subunit

T2 - Acta Naturae

AU - Moraleva, Anastasia A

AU - Deryabin, Alexander S

AU - Rubtsova, Maria P

AU - Dontsova, Olga A.

AU - Rubtsov, Yury P

PY - 2022

DA - 2022/05/10 00:00:00

PB - Acta Naturae Ltd

SP - 14-30

IS - 1

VL - 14

PMID - 35441050

SN - 2075-8251

SN - 2075-8243

ER -

BibTex |

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BibTex Copy

@article{2022_Moraleva,

author = {Anastasia A Moraleva and Alexander S Deryabin and Maria P Rubtsova and Olga A. Dontsova and Yury P Rubtsov},

title = {Eukaryotic Ribosome Biogenesis: The 40S Subunit},

journal = {Acta Naturae},

year = {2022},

volume = {14},

publisher = {Acta Naturae Ltd},

month = {may},

url = {https://doi.org/10.32607%2Factanaturae.11540},

number = {1},

pages = {14--30},

doi = {10.32607/actanaturae.11540}

}

MLA

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MLA Copy

Moraleva, Anastasia A., et al. “Eukaryotic Ribosome Biogenesis: The 40S Subunit.” Acta Naturae, vol. 14, no. 1, May. 2022, pp. 14-30. https://doi.org/10.32607%2Factanaturae.11540.

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Publisher

Acta Naturae Ltd

Journal

Acta Naturae

Quartile SCImago

Quartile WOS

Impact factor

ISSN

20758251 (Print)
20758243 (Print)

Labs

Laboratory of Nucleoprotein Chemistry, Department of Chemistry of Natural Compounds, Faculty of Chemistry

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