Open Access
Acta Naturae, volume 14, issue 2, pages 71-77
Imidazole Derivative As a Novel Translation Inhibitor
Publication type: Journal Article
Publication date: 2022-07-21
PubMed ID:
35923569
Hardware and Architecture
Computer Networks and Communications
Software
Abstract
Searching for novel compounds with antibiotic activity and understanding their mechanism of action is extremely important. The ribosome is one of the main targets for antibiotics in bacterial cells. Even if the molecule does not suit the clinical application for whatever reasons, an investigation of its mechanism of action can deepen our understanding of the ribosome function. Such data can inform us on how the already used translational inhibitors can be modified. In this study, we demonstrate that 1-(2-oxo-2-((4-phenoxyphenyl)amino)ethyl)-3-(p-tolyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-1-ium chloride inhibits protein synthesis both in vivo and in vitro.
Citations by journals
|
1
|
|
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
1 publication, 50%
|
|
Antibiotics
|
Antibiotics
1 publication, 50%
|
|
1
|
Citations by publishers
|
1
2
|
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 100%
|
|
1
2
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2022,2023],"ids":[0,0],"codes":[0,0],"imageUrls":["",""],"datasets":[{"label":"Citations number","data":[1,1],"backgroundColor":["#3B82F6","#3B82F6"],"percentage":["50","50"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["International Journal of Molecular Sciences","Antibiotics"],"ids":[14627,1488],"codes":[0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[1,1],"backgroundColor":["#3B82F6","#3B82F6"],"percentage":[50,50],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)"],"ids":[202],"codes":[0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[2],"backgroundColor":["#3B82F6"],"percentage":[100],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Lukianov D. A. et al. Imidazole Derivative As a Novel Translation Inhibitor // Acta Naturae. 2022. Vol. 14. No. 2. pp. 71-77.
GOST all authors (up to 50)
Copy
Lukianov D. A., Buev V. S., Ivanenkov Y., Kartsev V. G., Skvortsov D. A., Osterman I. A., Sergiev P. V. Imidazole Derivative As a Novel Translation Inhibitor // Acta Naturae. 2022. Vol. 14. No. 2. pp. 71-77.
Cite this
RIS
Copy
TY - JOUR
DO - 10.32607/actanaturae.11654
UR - https://doi.org/10.32607%2Factanaturae.11654
TI - Imidazole Derivative As a Novel Translation Inhibitor
T2 - Acta Naturae
AU - Lukianov, Dmitrii A
AU - Buev, Vitaly S
AU - Ivanenkov, Yan
AU - Kartsev, Victor G.
AU - Skvortsov, Dmitry A.
AU - Osterman, Ilya A.
AU - Sergiev, Petr V.
PY - 2022
DA - 2022/07/21 00:00:00
PB - Acta Naturae Ltd
SP - 71-77
IS - 2
VL - 14
PMID - 35923569
SN - 2075-8251
SN - 2075-8243
ER -
Cite this
BibTex
Copy
@article{2022_Lukianov,
author = {Dmitrii A Lukianov and Vitaly S Buev and Yan Ivanenkov and Victor G. Kartsev and Dmitry A. Skvortsov and Ilya A. Osterman and Petr V. Sergiev},
title = {Imidazole Derivative As a Novel Translation Inhibitor},
journal = {Acta Naturae},
year = {2022},
volume = {14},
publisher = {Acta Naturae Ltd},
month = {jul},
url = {https://doi.org/10.32607%2Factanaturae.11654},
number = {2},
pages = {71--77},
doi = {10.32607/actanaturae.11654}
}
Cite this
MLA
Copy
Lukianov, Dmitrii A., et al. “Imidazole Derivative As a Novel Translation Inhibitor.” Acta Naturae, vol. 14, no. 2, Jul. 2022, pp. 71-77. https://doi.org/10.32607%2Factanaturae.11654.