Open Access
Frontiers in Bioengineering and Biotechnology, volume 8
Cell Culture Based in vitro Test Systems for Anticancer Drug Screening
Publication type: Journal Article
Publication date: 2020-04-09
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.7
ISSN: 22964185
PubMed ID:
32328489
Biotechnology
Bioengineering
Histology
Biomedical Engineering
Abstract
The development of new high-tech systems for screening anticancer drugs is one of the main problems of preclinical screening. Poor correlation between preclinical in vitro and in vivo data with clinical trials remains a major concern. The choice of the correct tumor model at the stage of in vitro testing provides reduction in both financial and time costs during later stages due to the timely screening of ineffective agents. In view of the growing incidence of oncology, increasing the pace of the creation, development and testing of new antitumor agents, the improvement and expansion of new high-tech systems for preclinical in vitro screening, is becoming very important. The pharmaceutical industry presently relies on several widely used in vitro models, including two-dimensional models, three-dimensional models, microfluidic systems, Boyden's chamber and models created using 3D bioprinting. This review outlines and describes these tumor models including their use in research, in addition to their characteristics. This review therefore gives an insight into in vitro based testing which is of interest to researchers and clinicians from differing fields including pharmacy, preclinical studies and cell biology.
Citations by journals
1
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5
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7
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Cancers
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Cancers
7 publications, 8.54%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
5 publications, 6.1%
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Cells
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Cells
3 publications, 3.66%
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Biomicrofluidics
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Biomicrofluidics
2 publications, 2.44%
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Pharmaceutics
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Pharmaceutics
2 publications, 2.44%
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Processes
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Processes
2 publications, 2.44%
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Molecules
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Molecules
2 publications, 2.44%
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Drug Discovery Today
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Drug Discovery Today
2 publications, 2.44%
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Frontiers in Pharmacology
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Frontiers in Pharmacology
1 publication, 1.22%
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Current Drug Discovery Technologies
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Current Drug Discovery Technologies
1 publication, 1.22%
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F1000Research
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F1000Research
1 publication, 1.22%
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Assay and Drug Development Technologies
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Assay and Drug Development Technologies
1 publication, 1.22%
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Tissue Engineering - Part B: Reviews
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Tissue Engineering - Part B: Reviews
1 publication, 1.22%
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Micromachines
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Micromachines
1 publication, 1.22%
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Toxics
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Toxics
1 publication, 1.22%
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Biosensors
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Biosensors
1 publication, 1.22%
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ACS applied materials & interfaces
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ACS applied materials & interfaces
1 publication, 1.22%
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Frontiers in Oncology
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Frontiers in Oncology
1 publication, 1.22%
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Bioengineering
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Bioengineering
1 publication, 1.22%
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Annals of Biomedical Engineering
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Annals of Biomedical Engineering
1 publication, 1.22%
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Journal of Experimental and Clinical Cancer Research
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Journal of Experimental and Clinical Cancer Research
1 publication, 1.22%
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Pharmaceutical Chemistry Journal
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Pharmaceutical Chemistry Journal
1 publication, 1.22%
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Biochip Journal
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Biochip Journal
1 publication, 1.22%
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Experimental Eye Research
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Experimental Eye Research
1 publication, 1.22%
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Cell Reports Methods
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Cell Reports Methods
1 publication, 1.22%
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Experimental Hematology
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Experimental Hematology
1 publication, 1.22%
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Seminars in Cancer Biology
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Seminars in Cancer Biology
1 publication, 1.22%
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Trends in Biotechnology
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Trends in Biotechnology
1 publication, 1.22%
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Nanotechnology
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Nanotechnology
1 publication, 1.22%
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1
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3
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5
6
7
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Citations by publishers
5
10
15
20
25
30
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
27 publications, 32.93%
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Elsevier
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Elsevier
14 publications, 17.07%
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Springer Nature
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Springer Nature
9 publications, 10.98%
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Wiley
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Wiley
8 publications, 9.76%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
3 publications, 3.66%
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Frontiers Media S.A.
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Frontiers Media S.A.
2 publications, 2.44%
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American Institute of Physics (AIP)
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American Institute of Physics (AIP)
2 publications, 2.44%
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Mary Ann Liebert
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Mary Ann Liebert
2 publications, 2.44%
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Taylor & Francis
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Taylor & Francis
2 publications, 2.44%
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Bentham Science
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Bentham Science
1 publication, 1.22%
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F1000 Research
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F1000 Research
1 publication, 1.22%
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IOP Publishing
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IOP Publishing
1 publication, 1.22%
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IntechOpen
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IntechOpen, 1, 1.22%
IntechOpen
1 publication, 1.22%
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Future Medicine
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Future Medicine
1 publication, 1.22%
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Veterinary World
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Veterinary World, 1, 1.22%
Veterinary World
1 publication, 1.22%
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Human Stem Cells Institute OJSC (HSCI)
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Human Stem Cells Institute OJSC (HSCI), 1, 1.22%
Human Stem Cells Institute OJSC (HSCI)
1 publication, 1.22%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
1 publication, 1.22%
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5
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15
20
25
30
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Kitaeva K. V. et al. Cell Culture Based in vitro Test Systems for Anticancer Drug Screening // Frontiers in Bioengineering and Biotechnology. 2020. Vol. 8.
GOST all authors (up to 50)
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Kitaeva K. V., Rutland C. S., Rizvanov A. A., Solovyeva V. V. Cell Culture Based in vitro Test Systems for Anticancer Drug Screening // Frontiers in Bioengineering and Biotechnology. 2020. Vol. 8.
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TY - JOUR
DO - 10.3389/fbioe.2020.00322
UR - https://doi.org/10.3389%2Ffbioe.2020.00322
TI - Cell Culture Based in vitro Test Systems for Anticancer Drug Screening
T2 - Frontiers in Bioengineering and Biotechnology
AU - Kitaeva, Kristina V
AU - Rutland, Catrin S.
AU - Rizvanov, Albert A.
AU - Solovyeva, Valeriya V
PY - 2020
DA - 2020/04/09 00:00:00
PB - Frontiers Media S.A.
VL - 8
PMID - 32328489
SN - 2296-4185
ER -
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@article{2020_Kitaeva
author = {Kristina V Kitaeva and Catrin S. Rutland and Albert A. Rizvanov and Valeriya V Solovyeva},
title = {Cell Culture Based in vitro Test Systems for Anticancer Drug Screening},
journal = {Frontiers in Bioengineering and Biotechnology},
year = {2020},
volume = {8},
publisher = {Frontiers Media S.A.},
month = {apr},
url = {https://doi.org/10.3389%2Ffbioe.2020.00322},
doi = {10.3389/fbioe.2020.00322}
}