Open Access
Open access
Frontiers in Bioengineering and Biotechnology, volume 8

Cell Culture Based in vitro Test Systems for Anticancer Drug Screening

Publication typeJournal Article
Publication date2020-04-09
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor5.7
ISSN22964185
Biotechnology
Bioengineering
Histology
Biomedical Engineering
Abstract
The development of new high-tech systems for screening anticancer drugs is one of the main problems of preclinical screening. Poor correlation between preclinical in vitro and in vivo data with clinical trials remains a major concern. The choice of the correct tumor model at the stage of in vitro testing provides reduction in both financial and time costs during later stages due to the timely screening of ineffective agents. In view of the growing incidence of oncology, increasing the pace of the creation, development and testing of new antitumor agents, the improvement and expansion of new high-tech systems for preclinical in vitro screening, is becoming very important. The pharmaceutical industry presently relies on several widely used in vitro models, including two-dimensional models, three-dimensional models, microfluidic systems, Boyden's chamber and models created using 3D bioprinting. This review outlines and describes these tumor models including their use in research, in addition to their characteristics. This review therefore gives an insight into in vitro based testing which is of interest to researchers and clinicians from differing fields including pharmacy, preclinical studies and cell biology.

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GOST |
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GOST Copy
Kitaeva K. V. et al. Cell Culture Based in vitro Test Systems for Anticancer Drug Screening // Frontiers in Bioengineering and Biotechnology. 2020. Vol. 8.
GOST all authors (up to 50) Copy
Kitaeva K. V., Rutland C. S., Rizvanov A. A., Solovyeva V. V. Cell Culture Based in vitro Test Systems for Anticancer Drug Screening // Frontiers in Bioengineering and Biotechnology. 2020. Vol. 8.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3389/fbioe.2020.00322
UR - https://doi.org/10.3389%2Ffbioe.2020.00322
TI - Cell Culture Based in vitro Test Systems for Anticancer Drug Screening
T2 - Frontiers in Bioengineering and Biotechnology
AU - Kitaeva, Kristina V
AU - Rutland, Catrin S.
AU - Rizvanov, Albert A.
AU - Solovyeva, Valeriya V
PY - 2020
DA - 2020/04/09 00:00:00
PB - Frontiers Media S.A.
VL - 8
PMID - 32328489
SN - 2296-4185
ER -
BibTex
Cite this
BibTex Copy
@article{2020_Kitaeva
author = {Kristina V Kitaeva and Catrin S. Rutland and Albert A. Rizvanov and Valeriya V Solovyeva},
title = {Cell Culture Based in vitro Test Systems for Anticancer Drug Screening},
journal = {Frontiers in Bioengineering and Biotechnology},
year = {2020},
volume = {8},
publisher = {Frontiers Media S.A.},
month = {apr},
url = {https://doi.org/10.3389%2Ffbioe.2020.00322},
doi = {10.3389/fbioe.2020.00322}
}
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