Open Access
Frontiers in Cell and Developmental Biology, volume 8
High Cancer Susceptibility Candidate 8 Expression Is Associated With Poor Prognosis of Pancreatic Adenocarcinoma: Validated Analysis Based on Four Cancer Databases
3
Department of Pathology, Heilongjiang Province Land Reclamation Headquarter General Hospital, China
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Publication type: Journal Article
Publication date: 2020-06-04
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.5
ISSN: 2296634X
PubMed ID:
32582694
Cell Biology
Developmental Biology
Abstract
Objective The aim of this study was to explore the association between the expression of a long non-coding RNA (lncRNA), cancer susceptibility candidate 8 (CASC8), and pancreatic adenocarcinoma (PAAD). Materials and Methods starBase database was used to perform differential expression, survival, and competing endogenous RNA (ceRNA) network and H19/miR-671 correlation analyses for CASC8 in 178 PAAD samples. Using the cBioPortal database website, we analyzed the alteration in CASC8 expression and its correlation with the overall survival in PAAD. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were also performed using the circlncRNAnet database. Analysis of CASC8 polymorphisms was performed using the UCSC Xena database. Finally, the expression of CASC8 in Chinese PAAD tissues was validated by qPCR. Results The expression of CASC8 was observed to be high in 178 PAAD samples [fold change = 8.71, P = 0.0014, false discovery rate (FDR) = 0.04] and was related with poor prognosis, but not in pancreatic neuroendocrine tumor (pNET). CASC8 amplification was noted in 6% of the PAAD patients; however, the gene amplification did not affect the expression of CASC8 but was involved with the overall survival time of PAAD patients. Network analysis indicated that H19 is the ceRNA pair of CASC8 and that CASC8 competitively binds to miR-671 and might participate in the process of epithelial-to-mesenchymal transition (EMT). The correlation analysis showed that CASC8 was significantly negatively correlated with SMAD7. The analysis of CASC8 polymorphism showed that high copy number segment (CNS) of CASC8 is associated with low survival. Validation using PAAD tissues from Chinese patients was consistent with the in silico findings. Conclusion CASC8 is specifically expressed at a high level in PAAD and associated with poor prognosis, which might be through its interaction with H19, miR-671, and SMAD7. These results indicate that CASC8 could serve as a novel marker for predicting the prognosis and as a potential target for the therapy of PAAD.
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Wang Y. et al. High Cancer Susceptibility Candidate 8 Expression Is Associated With Poor Prognosis of Pancreatic Adenocarcinoma: Validated Analysis Based on Four Cancer Databases // Frontiers in Cell and Developmental Biology. 2020. Vol. 8.
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Wang Y., Yang Y., Wang Y., Li X., Xiao Yu., Wang W. High Cancer Susceptibility Candidate 8 Expression Is Associated With Poor Prognosis of Pancreatic Adenocarcinoma: Validated Analysis Based on Four Cancer Databases // Frontiers in Cell and Developmental Biology. 2020. Vol. 8.
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TY - JOUR
DO - 10.3389/fcell.2020.00392
UR - https://doi.org/10.3389%2Ffcell.2020.00392
TI - High Cancer Susceptibility Candidate 8 Expression Is Associated With Poor Prognosis of Pancreatic Adenocarcinoma: Validated Analysis Based on Four Cancer Databases
T2 - Frontiers in Cell and Developmental Biology
AU - Wang, Yingyi
AU - Yang, Yuemei
AU - Wang, Yanfeng
AU - Li, Xiaoou
AU - Xiao, Yu
AU - Wang, Wenze
PY - 2020
DA - 2020/06/04 00:00:00
PB - Frontiers Media S.A.
VL - 8
PMID - 32582694
SN - 2296-634X
ER -
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@article{2020_Wang,
author = {Yingyi Wang and Yuemei Yang and Yanfeng Wang and Xiaoou Li and Yu Xiao and Wenze Wang},
title = {High Cancer Susceptibility Candidate 8 Expression Is Associated With Poor Prognosis of Pancreatic Adenocarcinoma: Validated Analysis Based on Four Cancer Databases},
journal = {Frontiers in Cell and Developmental Biology},
year = {2020},
volume = {8},
publisher = {Frontiers Media S.A.},
month = {jun},
url = {https://doi.org/10.3389%2Ffcell.2020.00392},
doi = {10.3389/fcell.2020.00392}
}