Open Access
Frontiers in Genetics, volume 5
Chromatin modifications and DNA repair: beyond double-strand breaks
1
Department of Biology, Tufts University, Medford, MA, USA
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2
Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA
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Publication type: Journal Article
Publication date: 2014-09-05
Journal:
Frontiers in Genetics
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3.7
ISSN: 16648021
PubMed ID:
25250043
Genetics
Molecular Medicine
Genetics (clinical)
Abstract
DNA repair must take place in the context of chromatin, and chromatin modifications and DNA repair are intimately linked. The study of double-strand break repair has revealed numerous histone modifications that occur after induction of a DSB, and modification of the repair factors themselves can also occur. In some cases the function of the modification is at least partially understood, but in many cases it is not yet clear. Although DSB repair is a crucial activity for cell survival, DSBs account for only a small percentage of the DNA lesions that occur over the lifetime of a cell. Repair of single-strand gaps, nicks, stalled forks, alternative DNA structures, and base lesions must also occur in a chromatin context. There is increasing evidence that these repair pathways are also regulated by histone modifications and chromatin remodeling. In this review, we will summarize the current state of knowledge of chromatin modifications that occur during non-DSB repair, highlighting similarities and differences to DSB repair as well as remaining questions.
Citations by journals
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6
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
6 publications, 6.67%
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DNA Repair
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Scientific Reports
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2 publications, 2.22%
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Cell and Bioscience
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Cell and Bioscience
2 publications, 2.22%
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Nature Structural and Molecular Biology
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Nature Structural and Molecular Biology
2 publications, 2.22%
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PLoS ONE
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2 publications, 2.22%
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PLoS Genetics
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PLoS Genetics
2 publications, 2.22%
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Cell
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Cell
2 publications, 2.22%
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Journal of Biological Chemistry
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Journal of Biological Chemistry
2 publications, 2.22%
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Nucleus
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Nucleus
1 publication, 1.11%
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Journal of Cell Science
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Journal of Cell Science
1 publication, 1.11%
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Biochemical Journal
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Biochemical Journal
1 publication, 1.11%
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Biochemical Society Transactions
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Biochemical Society Transactions
1 publication, 1.11%
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Philosophical Transactions of the Royal Society B: Biological Sciences
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Philosophical Transactions of the Royal Society B: Biological Sciences
1 publication, 1.11%
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Frontiers in Plant Science
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Frontiers in Plant Science
1 publication, 1.11%
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Frontiers in Pharmacology
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Frontiers in Pharmacology
1 publication, 1.11%
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Oncology Reviews
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Oncology Reviews
1 publication, 1.11%
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Cancer Cell International
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Cancer Cell International
1 publication, 1.11%
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International Journal of Clinical Oncology
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International Journal of Clinical Oncology
1 publication, 1.11%
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Leukemia
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Leukemia
1 publication, 1.11%
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Nature Genetics
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Nature Genetics
1 publication, 1.11%
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BMC pharmacology & toxicology
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BMC pharmacology & toxicology
1 publication, 1.11%
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Cellular and Molecular Life Sciences
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Cellular and Molecular Life Sciences
1 publication, 1.11%
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AGE
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AGE
1 publication, 1.11%
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Trends in Genetics
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Trends in Genetics
1 publication, 1.11%
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Photoacoustics
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Photoacoustics
1 publication, 1.11%
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Citations by publishers
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5
10
15
20
25
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Elsevier
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Elsevier
21 publications, 23.33%
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Springer Nature
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Springer Nature
17 publications, 18.89%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
7 publications, 7.78%
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
4 publications, 4.44%
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Wiley
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Wiley
4 publications, 4.44%
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Proceedings of the National Academy of Sciences (PNAS)
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Proceedings of the National Academy of Sciences (PNAS)
3 publications, 3.33%
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Taylor & Francis
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Taylor & Francis
2 publications, 2.22%
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Future Medicine
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Future Medicine
2 publications, 2.22%
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Portland Press
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Portland Press
2 publications, 2.22%
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Frontiers Media S.A.
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Frontiers Media S.A.
2 publications, 2.22%
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American Society for Biochemistry and Molecular Biology
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American Society for Biochemistry and Molecular Biology
2 publications, 2.22%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
2 publications, 2.22%
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The Company of Biologists
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The Company of Biologists
1 publication, 1.11%
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The Royal Society
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The Royal Society
1 publication, 1.11%
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PagePress
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PagePress
1 publication, 1.11%
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Genetics Society of Japan/Nihon Iden Gakkai
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Genetics Society of Japan/Nihon Iden Gakkai, 1, 1.11%
Genetics Society of Japan/Nihon Iden Gakkai
1 publication, 1.11%
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Genetics Society of America
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Genetics Society of America
1 publication, 1.11%
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Oxford University Press
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Oxford University Press
1 publication, 1.11%
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Hindawi Limited
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Hindawi Limited
1 publication, 1.11%
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American Association for Cancer Research (AACR)
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American Association for Cancer Research (AACR)
1 publication, 1.11%
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eLife Sciences Publications
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eLife Sciences Publications
1 publication, 1.11%
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Annual Reviews
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Annual Reviews
1 publication, 1.11%
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Spandidos Publications
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Spandidos Publications
1 publication, 1.11%
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American Society for Cell Biology (ASCB)
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American Society for Cell Biology (ASCB)
1 publication, 1.11%
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5
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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House N. C. M. et al. Chromatin modifications and DNA repair: beyond double-strand breaks // Frontiers in Genetics. 2014. Vol. 5.
GOST all authors (up to 50)
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House N. C. M., Koch M. R., Freudenreich C. H. Chromatin modifications and DNA repair: beyond double-strand breaks // Frontiers in Genetics. 2014. Vol. 5.
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TY - JOUR
DO - 10.3389/fgene.2014.00296
UR - https://doi.org/10.3389%2Ffgene.2014.00296
TI - Chromatin modifications and DNA repair: beyond double-strand breaks
T2 - Frontiers in Genetics
AU - House, Nealia C M
AU - Koch, Melissa R
AU - Freudenreich, Catherine H
PY - 2014
DA - 2014/09/05 00:00:00
PB - Frontiers Media S.A.
VL - 5
PMID - 25250043
SN - 1664-8021
ER -
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@article{2014_House,
author = {Nealia C M House and Melissa R Koch and Catherine H Freudenreich},
title = {Chromatin modifications and DNA repair: beyond double-strand breaks},
journal = {Frontiers in Genetics},
year = {2014},
volume = {5},
publisher = {Frontiers Media S.A.},
month = {sep},
url = {https://doi.org/10.3389%2Ffgene.2014.00296},
doi = {10.3389/fgene.2014.00296}
}