Open Access
Frontiers in Genetics, volume 11
Methylation of Ribosomal RNA: A Mitochondrial Perspective
Lopez Sanchez M Isabel G
1, 2
,
Cipullo Miriam
1, 3
,
Gopalakrishna Shreekara
1, 3
,
Khawaja Anas
1, 3
,
Rorbach Joanna
1, 3
2
Centre for Eye Research Australia, Australia
|
Publication type: Journal Article
Publication date: 2020-07-17
Journal:
Frontiers in Genetics
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3.7
ISSN: 16648021
PubMed ID:
32765591
Genetics
Molecular Medicine
Genetics (clinical)
Abstract
Ribosomal RNA (rRNA) from all organisms undergoes post-transcriptional modifications that increase the diversity of its composition and activity. In mitochondria, specialized mitoribosomes are responsible for the synthesis of thirteen oxidative phosphorylation proteins encoded by the mitochondrial genome. Mitoribosomal RNA is also modified, with 10 modifications thus far identified and all corresponding modifying enzymes described. This form of epigenetic regulation of mitochondrial gene expression affects mitoribosome biogenesis and function. Here, we provide an overview on rRNA methylation and highlight critical work that is beginning to elucidate its role in mitochondrial gene expression. Given the similarities between bacterial and mitochondrial ribosomes, we focus on studies involving E. coli and human models. Furthermore, we highlight the use of state-of-the-art technologies, such as cryoEM in the study of rRNA methylation and its biological relevance. Understanding the mechanisms and functional relevance of this process represents an exciting frontier in the RNA biology and mitochondrial fields.
Citations by journals
1
2
3
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
3 publications, 15%
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Cells
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Cells
1 publication, 5%
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FEBS Journal
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FEBS Journal
1 publication, 5%
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IUBMB Life
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IUBMB Life
1 publication, 5%
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Wiley interdisciplinary reviews. RNA
1 publication, 5%
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Molecular Ecology
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1 publication, 5%
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Current Protocols
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Current Protocols
1 publication, 5%
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1 publication, 5%
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1 publication, 5%
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Cell Insight
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Cell Insight
1 publication, 5%
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Cell Discovery
1 publication, 5%
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Redox Biology
1 publication, 5%
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1
2
3
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Citations by publishers
1
2
3
4
5
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Wiley
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Wiley
5 publications, 25%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 20%
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Elsevier
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Elsevier
3 publications, 15%
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Frontiers Media S.A.
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Frontiers Media S.A.
2 publications, 10%
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Springer Nature
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Springer Nature
2 publications, 10%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 5%
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1
2
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4
5
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Lopez Sanchez M. I. G. et al. Methylation of Ribosomal RNA: A Mitochondrial Perspective // Frontiers in Genetics. 2020. Vol. 11.
GOST all authors (up to 50)
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Lopez Sanchez M. I. G., Cipullo M., Gopalakrishna S., Khawaja A., Rorbach J. Methylation of Ribosomal RNA: A Mitochondrial Perspective // Frontiers in Genetics. 2020. Vol. 11.
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TY - JOUR
DO - 10.3389/fgene.2020.00761
UR - https://doi.org/10.3389%2Ffgene.2020.00761
TI - Methylation of Ribosomal RNA: A Mitochondrial Perspective
T2 - Frontiers in Genetics
AU - Lopez Sanchez, M Isabel G
AU - Cipullo, Miriam
AU - Gopalakrishna, Shreekara
AU - Khawaja, Anas
AU - Rorbach, Joanna
PY - 2020
DA - 2020/07/17 00:00:00
PB - Frontiers Media S.A.
VL - 11
PMID - 32765591
SN - 1664-8021
ER -
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@article{2020_Lopez Sanchez
author = {M Isabel G Lopez Sanchez and Miriam Cipullo and Shreekara Gopalakrishna and Anas Khawaja and Joanna Rorbach},
title = {Methylation of Ribosomal RNA: A Mitochondrial Perspective},
journal = {Frontiers in Genetics},
year = {2020},
volume = {11},
publisher = {Frontiers Media S.A.},
month = {jul},
url = {https://doi.org/10.3389%2Ffgene.2020.00761},
doi = {10.3389/fgene.2020.00761}
}