Open Access
Open access
Frontiers in Genetics, volume 11

Methylation of Ribosomal RNA: A Mitochondrial Perspective

Lopez Sanchez M Isabel G 1, 2
Cipullo Miriam 1, 3
Gopalakrishna Shreekara 1, 3
Khawaja Anas 1, 3
Rorbach Joanna 1, 3
Publication typeJournal Article
Publication date2020-07-17
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor3.7
ISSN16648021
Genetics
Molecular Medicine
Genetics (clinical)
Abstract
Ribosomal RNA (rRNA) from all organisms undergoes post-transcriptional modifications that increase the diversity of its composition and activity. In mitochondria, specialized mitoribosomes are responsible for the synthesis of thirteen oxidative phosphorylation proteins encoded by the mitochondrial genome. Mitoribosomal RNA is also modified, with 10 modifications thus far identified and all corresponding modifying enzymes described. This form of epigenetic regulation of mitochondrial gene expression affects mitoribosome biogenesis and function. Here, we provide an overview on rRNA methylation and highlight critical work that is beginning to elucidate its role in mitochondrial gene expression. Given the similarities between bacterial and mitochondrial ribosomes, we focus on studies involving E. coli and human models. Furthermore, we highlight the use of state-of-the-art technologies, such as cryoEM in the study of rRNA methylation and its biological relevance. Understanding the mechanisms and functional relevance of this process represents an exciting frontier in the RNA biology and mitochondrial fields.

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GOST Copy
Lopez Sanchez M. I. G. et al. Methylation of Ribosomal RNA: A Mitochondrial Perspective // Frontiers in Genetics. 2020. Vol. 11.
GOST all authors (up to 50) Copy
Lopez Sanchez M. I. G., Cipullo M., Gopalakrishna S., Khawaja A., Rorbach J. Methylation of Ribosomal RNA: A Mitochondrial Perspective // Frontiers in Genetics. 2020. Vol. 11.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3389/fgene.2020.00761
UR - https://doi.org/10.3389%2Ffgene.2020.00761
TI - Methylation of Ribosomal RNA: A Mitochondrial Perspective
T2 - Frontiers in Genetics
AU - Lopez Sanchez, M Isabel G
AU - Cipullo, Miriam
AU - Gopalakrishna, Shreekara
AU - Khawaja, Anas
AU - Rorbach, Joanna
PY - 2020
DA - 2020/07/17 00:00:00
PB - Frontiers Media S.A.
VL - 11
PMID - 32765591
SN - 1664-8021
ER -
BibTex
Cite this
BibTex Copy
@article{2020_Lopez Sanchez
author = {M Isabel G Lopez Sanchez and Miriam Cipullo and Shreekara Gopalakrishna and Anas Khawaja and Joanna Rorbach},
title = {Methylation of Ribosomal RNA: A Mitochondrial Perspective},
journal = {Frontiers in Genetics},
year = {2020},
volume = {11},
publisher = {Frontiers Media S.A.},
month = {jul},
url = {https://doi.org/10.3389%2Ffgene.2020.00761},
doi = {10.3389/fgene.2020.00761}
}
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