Open Access
Frontiers in Oncology, volume 2
Getting in (and out of) the loop: regulating higher order telomere structures
Publication type: Journal Article
Publication date: 2012-11-30
Journal:
Frontiers in Oncology
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 4.7
ISSN: 2234943X
PubMed ID:
23226680
Cancer Research
Oncology
Abstract
The DNA at the ends of linear chromosomes (the telomere) folds back onto itself and forms an intramolecular lariat-like structure. Although the telomere loop has been implicated in the protection of chromosome ends from nuclease-mediated resection and unscheduled DNA repair activities, it potentially poses an obstacle to the DNA replication machinery during S phase. Therefore, the coordinated regulation of telomere loop formation, maintenance and resolution is required in order to establish a balance between protecting the chromosome ends and promoting their duplication prior to cell division. Until recently, the only factor know to influence telomere looping in human cells was TRF2, a component of the shelterin complex. Recent work in yeast and mouse cells has uncovered additional regulatory factors that affect the loop structure at telomeres. In the following “perspective” we will outline what is known about telomere looping and highlight the latest results regarding the regulation of this chromosome end structure. We will speculate about how the manipulation of the telomere loop may have therapeutic implications in terms of diseases associated with telomere dysfunction and uncontrolled proliferation.
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1
2
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Luke-Glaser S., Poschke H., Luke B. Getting in (and out of) the loop: regulating higher order telomere structures // Frontiers in Oncology. 2012. Vol. 2.
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Luke-Glaser S., Poschke H., Luke B. Getting in (and out of) the loop: regulating higher order telomere structures // Frontiers in Oncology. 2012. Vol. 2.
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TY - JOUR
DO - 10.3389/fonc.2012.00180
UR - https://doi.org/10.3389%2Ffonc.2012.00180
TI - Getting in (and out of) the loop: regulating higher order telomere structures
T2 - Frontiers in Oncology
AU - Luke-Glaser, Sarah
AU - Poschke, Heiko
AU - Luke, Brian
PY - 2012
DA - 2012/11/30 00:00:00
PB - Frontiers Media S.A.
VL - 2
PMID - 23226680
SN - 2234-943X
ER -
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@article{2012_Luke-Glaser,
author = {Sarah Luke-Glaser and Heiko Poschke and Brian Luke},
title = {Getting in (and out of) the loop: regulating higher order telomere structures},
journal = {Frontiers in Oncology},
year = {2012},
volume = {2},
publisher = {Frontiers Media S.A.},
month = {nov},
url = {https://doi.org/10.3389%2Ffonc.2012.00180},
doi = {10.3389/fonc.2012.00180}
}