Open Access
Frontiers in Oncology, volume 3
Cdc13 at a crossroads of telomerase action
1
CNRS/Inserm/Marseille/AIX University/IPC, Cancer Research Center of Marseille, 27 bd Leï Roure, BP 30059, Marseille, 13273, France
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Publication type: Journal Article
Publication date: 2013-02-28
Journal:
Frontiers in Oncology
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 4.7
ISSN: 2234943X
PubMed ID:
23450759
Cancer Research
Oncology
Abstract
Telomere elongation by telomerase involves sequential steps that must be highly coordinated to ensure the maintenance of telomeres at a proper length. Telomerase is delivered to telomere ends, where it engages single-strand DNA end as a primer, elongates it, and dissociates from the telomeres via mechanism that is likely coupled to the synthesis of the complementary C-strand. In Saccharomyces cerevisiae, the telomeric G-overhang bound Cdc13 acts as a platform for the recruitment of several factors that orchestrate timely transitions between these steps. In this review, we focus on some unresolved aspects of telomerase recruitment and on the mechanisms that regulate telomere elongation by telomerase after its recruitment to chromosome ends. We also highlight the key regulatory modifications of Cdc13 that promote transitions between the steps of telomere elongation.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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TY - JOUR
DO - 10.3389/fonc.2013.00039
UR - https://doi.org/10.3389%2Ffonc.2013.00039
TI - Cdc13 at a crossroads of telomerase action
T2 - Frontiers in Oncology
AU - Churikov, Dmitri
AU - Corda, Yves
AU - Luciano, Pierre
AU - Géli, Vincent
PY - 2013
DA - 2013/02/28 00:00:00
PB - Frontiers Media S.A.
VL - 3
PMID - 23450759
SN - 2234-943X
ER -
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@article{2013_Churikov,
author = {Dmitri Churikov and Yves Corda and Pierre Luciano and Vincent Géli},
title = {Cdc13 at a crossroads of telomerase action},
journal = {Frontiers in Oncology},
year = {2013},
volume = {3},
publisher = {Frontiers Media S.A.},
month = {feb},
url = {https://doi.org/10.3389%2Ffonc.2013.00039},
doi = {10.3389/fonc.2013.00039}
}