Open Access
Frontiers in Pharmacology, volume 9
Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example
Nikitina Liliya E
1, 2
,
Kiselev Sergei V
1
,
Startseva Valeriya A
1
,
Bodrov Andrei V
1
,
Azizova Zulfiya R
1
,
Shipina Olga T
3
,
Fedyunina Inna V
1
,
Boichuk Sergei V
1
,
Lodochnikova Olga A
4
,
Klochkov Vladimir V
2
,
Galiullina Leisan F
2
,
Khaliullina Aliya V
1, 2
Publication type: Journal Article
Publication date: 2018-02-19
Journal:
Frontiers in Pharmacology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16639812
PubMed ID:
29515444
Pharmacology
Pharmacology (medical)
Abstract
In this article we present the synthesis of enantiomerically pure sulfoxide and study the influence of this compound on hemostasis. Detailed NMR studies and molecular dynamics simulations using sodium dodecyl sulfate (SDS) membrane models indicated that the bicyclic fragment of sulfoxide was embedded into the SDS micelle whereas the -SO(CH2)2OH fragment remained on the surface of the micelle and was in contact with the solvent. We also found that the pro-coagulative activity of sulfoxide was due to its ability to inhibit platelet activation and inhibited the catalytic activity of phospholipid surface which was involved in formation of coagulation clotting factor complexes.
Citations by journals
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2
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Frontiers in Pharmacology
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Frontiers in Pharmacology
2 publications, 13.33%
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Russian Chemical Bulletin
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Russian Chemical Bulletin
2 publications, 13.33%
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Bioengineering
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1 publication, 6.67%
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Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
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Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
1 publication, 6.67%
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Journal of Molecular Liquids
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Journal of Molecular Liquids
1 publication, 6.67%
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ACS Applied Bio Materials
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ACS Applied Bio Materials
1 publication, 6.67%
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Biomolecules
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Biomolecules
1 publication, 6.67%
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Natural Product Communications
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Natural Product Communications
1 publication, 6.67%
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European Journal of Medicinal Chemistry
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European Journal of Medicinal Chemistry
1 publication, 6.67%
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Journal of Molecular Structure
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Journal of Molecular Structure
1 publication, 6.67%
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ChemistrySelect
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ChemistrySelect
1 publication, 6.67%
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FASEB Journal
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FASEB Journal
1 publication, 6.67%
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Biomimetics
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Biomimetics
1 publication, 6.67%
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1
2
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Citations by publishers
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1
2
3
4
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Elsevier
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Elsevier
4 publications, 26.67%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 20%
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Frontiers Media S.A.
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Frontiers Media S.A.
2 publications, 13.33%
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Springer Nature
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Springer Nature
2 publications, 13.33%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 6.67%
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SAGE
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SAGE
1 publication, 6.67%
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Wiley
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Wiley
1 publication, 6.67%
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Federation of American Societies for Experimental Biology (FASEB)
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Federation of American Societies for Experimental Biology (FASEB)
1 publication, 6.67%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Nikitina L. E. et al. Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example // Frontiers in Pharmacology. 2018. Vol. 9.
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Nikitina L. E., Kiselev S. V., Startseva V. A., Bodrov A. V., Azizova Z. R., Shipina O. T., Fedyunina I. V., Boichuk S. V., Lodochnikova O. A., Klochkov V. V., Galiullina L. F., Khaliullina A. V. Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example // Frontiers in Pharmacology. 2018. Vol. 9.
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TY - JOUR
DO - 10.3389/fphar.2018.00116
UR - https://doi.org/10.3389%2Ffphar.2018.00116
TI - Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example
T2 - Frontiers in Pharmacology
AU - Nikitina, Liliya E
AU - Kiselev, Sergei V
AU - Startseva, Valeriya A
AU - Bodrov, Andrei V
AU - Azizova, Zulfiya R
AU - Shipina, Olga T
AU - Fedyunina, Inna V
AU - Boichuk, Sergei V
AU - Lodochnikova, Olga A
AU - Klochkov, Vladimir V
AU - Galiullina, Leisan F
AU - Khaliullina, Aliya V
PY - 2018
DA - 2018/02/19 00:00:00
PB - Frontiers Media S.A.
VL - 9
PMID - 29515444
SN - 1663-9812
ER -
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@article{2018_Nikitina,
author = {Liliya E Nikitina and Sergei V Kiselev and Valeriya A Startseva and Andrei V Bodrov and Zulfiya R Azizova and Olga T Shipina and Inna V Fedyunina and Sergei V Boichuk and Olga A Lodochnikova and Vladimir V Klochkov and Leisan F Galiullina and Aliya V Khaliullina},
title = {Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example},
journal = {Frontiers in Pharmacology},
year = {2018},
volume = {9},
publisher = {Frontiers Media S.A.},
month = {feb},
url = {https://doi.org/10.3389%2Ffphar.2018.00116},
doi = {10.3389/fphar.2018.00116}
}