Open Access
Frontiers in Pharmacology, volume 9
Mitochondrial-Targeting Anticancer Agent Conjugates and Nanocarrier Systems for Cancer Treatment
1
Department of Pharmacy, College of Pharmacy, The Catholic University of Korea, South Korea
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Publication type: Journal Article
Publication date: 2018-08-17
Journal:
Frontiers in Pharmacology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16639812
PubMed ID:
30174604
Pharmacology
Pharmacology (medical)
Abstract
The mitochondrion is an important intracellular organelle for drug targeting due to its key roles and functions in cellular proliferation and death. In the last few decades, several studies have revealed mitochondrial functions, attracting the focus of many researchers to work in this field over nuclear targeting. Mitochondrial targeting was initiated in 1995 with a triphenylphosphonium-thiobutyl conjugate as an antioxidant agent. The major driving force for mitochondrial targeting in cancer cells is the higher mitochondrial membrane potential compared with that of the cytosol, which allows some molecules to selectively target mitochondria. In this review, we discuss mitochondria-targeting ligand-conjugated anticancer agents and their in vitro and in vivo behaviors. In addition, we describe a mitochondria-targeting nanocarrier system for anticancer drug delivery. As previously reported, several agents have been known to have mitochondrial targeting potential; however, they are not sufficient for direct application for cancer therapy. Thus, many studies have focused on direct conjugation of targeting ligands to therapeutic agents to improve their efficacy. There are many variables for optimal mitochondria-targeted agent development, such as choosing a correct targeting ligand and linker. However, using the nanocarrier system could solve some issues related to solubility and selectivity. Thus, this review focuses on mitochondria-targeting drug conjugates and mitochondria-targeted nanocarrier systems for anticancer agent delivery.
Citations by journals
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
4 publications, 3.96%
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Bioorganic Chemistry
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Scientific Reports
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Scientific Reports
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Journal of Drug Delivery Science and Technology
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Journal of Drug Delivery Science and Technology
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Frontiers in Pharmacology
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Molecules
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Molecules
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Journal of Pharmaceutical Investigation
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Journal of Pharmaceutical Investigation
2 publications, 1.98%
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Journal of Controlled Release
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Journal of Controlled Release
2 publications, 1.98%
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Chemical Engineering Journal
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Chemical Engineering Journal
2 publications, 1.98%
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Journal of Molecular Structure
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Journal of Molecular Structure
2 publications, 1.98%
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Angewandte Chemie
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Angewandte Chemie
2 publications, 1.98%
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Angewandte Chemie - International Edition
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Angewandte Chemie - International Edition
2 publications, 1.98%
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Archiv der Pharmazie
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1 publication, 0.99%
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1 publication, 0.99%
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Current Pharmaceutical Design
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Current Pharmaceutical Design
1 publication, 0.99%
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1 publication, 0.99%
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Nanomedicine
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Nanomedicine
1 publication, 0.99%
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Antioxidants and Redox Signaling
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1 publication, 0.99%
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Tropical Medicine and Infectious Disease
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1 publication, 0.99%
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Cells
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Cells
1 publication, 0.99%
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Biomolecules
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Biomolecules
1 publication, 0.99%
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Frontiers in Oncology
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Frontiers in Oncology
1 publication, 0.99%
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Pharmaceuticals
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Pharmaceuticals
1 publication, 0.99%
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BMC Cancer
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BMC Cancer
1 publication, 0.99%
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Leukemia
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Leukemia
1 publication, 0.99%
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Molecular and Cellular Biochemistry
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Molecular and Cellular Biochemistry
1 publication, 0.99%
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European Journal of Medicinal Chemistry
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European Journal of Medicinal Chemistry
1 publication, 0.99%
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Seminars in Cancer Biology
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Seminars in Cancer Biology
1 publication, 0.99%
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Citations by publishers
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5
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25
30
35
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Elsevier
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Elsevier
31 publications, 30.69%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
14 publications, 13.86%
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Wiley
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Wiley
12 publications, 11.88%
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Springer Nature
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Springer Nature
10 publications, 9.9%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
6 publications, 5.94%
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Bentham Science
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Bentham Science
5 publications, 4.95%
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Frontiers Media S.A.
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Frontiers Media S.A.
3 publications, 2.97%
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IOP Publishing
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IOP Publishing
2 publications, 1.98%
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Future Medicine
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Future Medicine
1 publication, 0.99%
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Mary Ann Liebert
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Mary Ann Liebert
1 publication, 0.99%
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SAGE
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SAGE
1 publication, 0.99%
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Shenyang Pharmaceutical University
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Shenyang Pharmaceutical University, 1, 0.99%
Shenyang Pharmaceutical University
1 publication, 0.99%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
1 publication, 0.99%
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Dove Medical Press
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Dove Medical Press
1 publication, 0.99%
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Taylor & Francis
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Taylor & Francis
1 publication, 0.99%
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AME Publishing Company
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AME Publishing Company
1 publication, 0.99%
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Spandidos Publications
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Spandidos Publications
1 publication, 0.99%
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Proceedings of the National Academy of Sciences (PNAS)
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Proceedings of the National Academy of Sciences (PNAS)
1 publication, 0.99%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Battogtokh G. et al. Mitochondrial-Targeting Anticancer Agent Conjugates and Nanocarrier Systems for Cancer Treatment // Frontiers in Pharmacology. 2018. Vol. 9.
GOST all authors (up to 50)
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Battogtokh G., Cho Y., Lee J. Y., Lee H. S., Kang H. C. Mitochondrial-Targeting Anticancer Agent Conjugates and Nanocarrier Systems for Cancer Treatment // Frontiers in Pharmacology. 2018. Vol. 9.
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TY - JOUR
DO - 10.3389/fphar.2018.00922
UR - https://doi.org/10.3389%2Ffphar.2018.00922
TI - Mitochondrial-Targeting Anticancer Agent Conjugates and Nanocarrier Systems for Cancer Treatment
T2 - Frontiers in Pharmacology
AU - Battogtokh, Gantumur
AU - Cho, Yong-Yeon
AU - Lee, Joo Young
AU - Lee, Hye Suk
AU - Kang, Han Chang
PY - 2018
DA - 2018/08/17 00:00:00
PB - Frontiers Media S.A.
VL - 9
PMID - 30174604
SN - 1663-9812
ER -
Cite this
BibTex
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@article{2018_Battogtokh,
author = {Gantumur Battogtokh and Yong-Yeon Cho and Joo Young Lee and Hye Suk Lee and Han Chang Kang},
title = {Mitochondrial-Targeting Anticancer Agent Conjugates and Nanocarrier Systems for Cancer Treatment},
journal = {Frontiers in Pharmacology},
year = {2018},
volume = {9},
publisher = {Frontiers Media S.A.},
month = {aug},
url = {https://doi.org/10.3389%2Ffphar.2018.00922},
doi = {10.3389/fphar.2018.00922}
}