Open Access
Frontiers in Physiology, volume 10
Alterations of Functional Brain Connectivity After Long-Duration Spaceflight as Revealed by fMRI
Pechenkova Ekaterina
1
,
Nosikova Inna
2
,
Rumshiskaya Alena
3
,
Litvinova Liudmila
3
,
Rukavishnikov Ilya
2
,
Mershina Elena
4
,
Sinitsyn Valentin
4
,
Van Ombergen Angelique
5
,
Jeurissen Ben
6
,
Jillings Steven
5, 7
,
Laureys Steven
7
,
Sijbers Jan
6
,
Grishin Alexey
8
,
Chernikova Ludmila
2
,
Naumov Ivan
2
,
Kornilova Ludmila
2
,
Wuyts Floris L.
5
,
Kozlovskaya Inessa
2
3
Radiology Department, Federal Center of Treatment and Rehabilitation, Russia
|
5
6
7
Coma Science Group, GIGA Consciousness Research Centre, Neurology Department, University Hospital of Liège, Belgium
|
8
Gagarin Cosmonauts Training Center, Russia
|
Publication type: Journal Article
Publication date: 2019-07-04
Journal:
Frontiers in Physiology
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 4
ISSN: 1664042X
PubMed ID:
31333476
Physiology
Physiology (medical)
Abstract
The present study reports alterations of task-based functional brain connectivity in a group of 11 cosmonauts after a long-duration spaceflight, compared to a healthy control group not involved in the space program. To elicit the postural and locomotor sensorimotor mechanisms that are usually most significantly impaired when space travelers return to Earth, a plantar stimulation paradigm was used in a block design fMRI study. The motor control system activated by the plantar stimulation involved the pre-central and post-central gyri, SMA, SII/operculum, and, to a lesser degree, the insular cortex and cerebellum. While no post-flight alterations were observed in terms of activation, the network-based statistics approach revealed task-specific functional connectivity modifications within a broader set of regions involving the activation sites along with other parts of the sensorimotor neural network and the visual, proprioceptive, and vestibular systems. The most notable findings included a post-flight increase in the stimulation-specific connectivity of the right posterior supramarginal gyrus with the rest of the brain; a strengthening of connections between the left and right insulae; decreased connectivity of the vestibular nuclei, right inferior parietal cortex (BA40) and cerebellum with areas associated with motor, visual, vestibular, and proprioception functions; and decreased coupling of the cerebellum with the visual cortex and the right inferior parietal cortex. The severity of space motion sickness symptoms was found to correlate with a post- to pre-flight difference in connectivity between the right supramarginal gyrus and the left anterior insula. Due to the complex nature and rapid dynamics of adaptation to gravity alterations, the post-flight findings might be attributed to both the long-term microgravity exposure and to the readaptation to Earth’s gravity that took place between the landing and post-flight MRI session. Nevertheless, the results have implications for the multisensory reweighting and gravitational motor system theories, generating hypotheses to be tested in future research.
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Citations by publishers
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1 publication, 1.61%
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1 publication, 1.61%
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2
4
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12
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Pechenkova E. et al. Alterations of Functional Brain Connectivity After Long-Duration Spaceflight as Revealed by fMRI // Frontiers in Physiology. 2019. Vol. 10.
GOST all authors (up to 50)
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Pechenkova E., Nosikova I., Rumshiskaya A., Litvinova L., Rukavishnikov I., Mershina E., Sinitsyn V., Van Ombergen A., Jeurissen B., Jillings S., Laureys S., Sijbers J., Grishin A., Chernikova L., Naumov I., Kornilova L., Wuyts F. L., Tomilovskaya E., Kozlovskaya I. Alterations of Functional Brain Connectivity After Long-Duration Spaceflight as Revealed by fMRI // Frontiers in Physiology. 2019. Vol. 10.
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TY - JOUR
DO - 10.3389/fphys.2019.00761
UR - https://doi.org/10.3389%2Ffphys.2019.00761
TI - Alterations of Functional Brain Connectivity After Long-Duration Spaceflight as Revealed by fMRI
T2 - Frontiers in Physiology
AU - Pechenkova, Ekaterina
AU - Nosikova, Inna
AU - Rumshiskaya, Alena
AU - Litvinova, Liudmila
AU - Rukavishnikov, Ilya
AU - Mershina, Elena
AU - Sinitsyn, Valentin
AU - Van Ombergen, Angelique
AU - Jeurissen, Ben
AU - Jillings, Steven
AU - Laureys, Steven
AU - Sijbers, Jan
AU - Grishin, Alexey
AU - Chernikova, Ludmila
AU - Naumov, Ivan
AU - Kornilova, Ludmila
AU - Wuyts, Floris L.
AU - Tomilovskaya, Elena
AU - Kozlovskaya, Inessa
PY - 2019
DA - 2019/07/04 00:00:00
PB - Frontiers Media S.A.
VL - 10
PMID - 31333476
SN - 1664-042X
ER -
Cite this
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Copy
@article{2019_Pechenkova,
author = {Ekaterina Pechenkova and Inna Nosikova and Alena Rumshiskaya and Liudmila Litvinova and Ilya Rukavishnikov and Elena Mershina and Valentin Sinitsyn and Angelique Van Ombergen and Ben Jeurissen and Steven Jillings and Steven Laureys and Jan Sijbers and Alexey Grishin and Ludmila Chernikova and Ivan Naumov and Ludmila Kornilova and Floris L. Wuyts and Elena Tomilovskaya and Inessa Kozlovskaya},
title = {Alterations of Functional Brain Connectivity After Long-Duration Spaceflight as Revealed by fMRI},
journal = {Frontiers in Physiology},
year = {2019},
volume = {10},
publisher = {Frontiers Media S.A.},
month = {jul},
url = {https://doi.org/10.3389%2Ffphys.2019.00761},
doi = {10.3389/fphys.2019.00761}
}