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Applied Sciences (Switzerland), volume 10, issue 3, pages 805

Two-Photon Excitation of Azobenzene Photoswitches for Synthetic Optogenetics

Publication typeJournal Article
Publication date2020-01-23
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor2.7
ISSN20763417
Computer Science Applications
Process Chemistry and Technology
General Materials Science
Instrumentation
General Engineering
Fluid Flow and Transfer Processes
Abstract

Synthetic optogenetics is an emerging optical technique that enables users to photocontrol molecules, proteins, and cells in vitro and in vivo. This is achieved by use of synthetic chromophores—denoted photoswitches—that undergo light-dependent changes (e.g., isomerization), which are meticulously designed to interact with unique cellular targets, notably proteins. Following light illumination, the changes adopted by photoswitches are harnessed to affect the function of nearby proteins. In most instances, photoswitches absorb visible light, wavelengths of poor tissue penetration, and excessive scatter. These shortcomings impede their use in vivo. To overcome these challenges, photoswitches of red-shifted absorbance have been developed. Notably, this shift in absorbance also increases their compatibility with two-photon excitation (2PE) methods. Here, we provide an overview of recent efforts devoted towards optimizing azobenzene-based photoswitches for 2PE and their current applications.

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GOST |
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GOST Copy
Kellner S., Berlin S. Two-Photon Excitation of Azobenzene Photoswitches for Synthetic Optogenetics // Applied Sciences (Switzerland). 2020. Vol. 10. No. 3. p. 805.
GOST all authors (up to 50) Copy
Kellner S., Berlin S. Two-Photon Excitation of Azobenzene Photoswitches for Synthetic Optogenetics // Applied Sciences (Switzerland). 2020. Vol. 10. No. 3. p. 805.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/app10030805
UR - https://doi.org/10.3390%2Fapp10030805
TI - Two-Photon Excitation of Azobenzene Photoswitches for Synthetic Optogenetics
T2 - Applied Sciences (Switzerland)
AU - Kellner, Shai
AU - Berlin, Shai
PY - 2020
DA - 2020/01/23 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 805
IS - 3
VL - 10
SN - 2076-3417
ER -
BibTex |
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BibTex Copy
@article{2020_Kellner
author = {Shai Kellner and Shai Berlin},
title = {Two-Photon Excitation of Azobenzene Photoswitches for Synthetic Optogenetics},
journal = {Applied Sciences (Switzerland)},
year = {2020},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jan},
url = {https://doi.org/10.3390%2Fapp10030805},
number = {3},
pages = {805},
doi = {10.3390/app10030805}
}
MLA
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MLA Copy
Kellner, Shai, and Shai Berlin. “Two-Photon Excitation of Azobenzene Photoswitches for Synthetic Optogenetics.” Applied Sciences (Switzerland), vol. 10, no. 3, Jan. 2020, p. 805. https://doi.org/10.3390%2Fapp10030805.
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