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Biomolecules, volume 10, issue 3, pages 378

Targeted Isolation of Lignans from Trachelospermum asiaticum Using Molecular Networking and Hierarchical Clustering Analysis

Lee Jiho 1
Yang Hong Seok 1
Jeong Hyogeun 1
Kim Jung Hwan 2
Yang Heejung 1
1
 
Laboratory of Natural Products Chemistry, College of Pharmacy, Kangwon National University, Chuncheon 24341, Korea
2
 
Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea
Publication typeJournal Article
Publication date2020-03-01
Journal: Biomolecules
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor5.5
ISSN2218273X
PubMed ID:  32121489
Biochemistry
Molecular Biology
Abstract

High-resolution-mass-spectrometry (HR-MS) methods rapidly provide extensive structural information for the isolation of metabolites in natural products. However, they may occasionally provide more information than required and interfere with the targeted analysis of natural products. In this study, we aimed to selectively isolate lignans from Trachelospermum asiaticum by applying the Global Natural Product Social Molecular Networking (GNPS) platform and hierarchical clustering analysis (HCA). T. asiaticum, which contains lignans, triterpenoids and flavonoids that possess various biological activities, was analyzed in a data-dependent acquisition (DDA) analysis mode using HR-MS. The preprocessed MS spectra were applied not only to GNPS for molecular networking but also to HCA based on similarity patterns between two nodes. The combination of these two methods reliably helped in the targeted isolation of lignan-type metabolites, which are expected to possess potent anti-cancer or anti-inflammatory activities.

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Lee J. et al. Targeted Isolation of Lignans from Trachelospermum asiaticum Using Molecular Networking and Hierarchical Clustering Analysis // Biomolecules. 2020. Vol. 10. No. 3. p. 378.
GOST all authors (up to 50) Copy
Lee J., Yang H. S., Jeong H., Kim J. H., Yang H. Targeted Isolation of Lignans from Trachelospermum asiaticum Using Molecular Networking and Hierarchical Clustering Analysis // Biomolecules. 2020. Vol. 10. No. 3. p. 378.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/biom10030378
UR - https://doi.org/10.3390%2Fbiom10030378
TI - Targeted Isolation of Lignans from Trachelospermum asiaticum Using Molecular Networking and Hierarchical Clustering Analysis
T2 - Biomolecules
AU - Lee, Jiho
AU - Yang, Hong Seok
AU - Jeong, Hyogeun
AU - Kim, Jung Hwan
AU - Yang, Heejung
PY - 2020
DA - 2020/03/01 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 378
IS - 3
VL - 10
PMID - 32121489
SN - 2218-273X
ER -
BibTex |
Cite this
BibTex Copy
@article{2020_Lee
author = {Jiho Lee and Hong Seok Yang and Hyogeun Jeong and Jung Hwan Kim and Heejung Yang},
title = {Targeted Isolation of Lignans from Trachelospermum asiaticum Using Molecular Networking and Hierarchical Clustering Analysis},
journal = {Biomolecules},
year = {2020},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {mar},
url = {https://doi.org/10.3390%2Fbiom10030378},
number = {3},
pages = {378},
doi = {10.3390/biom10030378}
}
MLA
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MLA Copy
Lee, Jiho, et al. “Targeted Isolation of Lignans from Trachelospermum asiaticum Using Molecular Networking and Hierarchical Clustering Analysis.” Biomolecules, vol. 10, no. 3, Mar. 2020, p. 378. https://doi.org/10.3390%2Fbiom10030378.
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