Open Access
Open access
Biomolecules, volume 11, issue 11, pages 1665

LncRNAs: Novel Biomarkers for Pancreatic Cancer

Publication typeJournal Article
Publication date2021-11-10
Journal: Biomolecules
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor5.5
ISSN2218273X
PubMed ID:  34827663
Biochemistry
Molecular Biology
Abstract
Pancreatic cancer is one of the most deadly neoplasms and the seventh major cause of cancer-related deaths among both males and females. This cancer has a poor prognosis due to the lack of appropriate methods for early detection of cancer. Long non-coding RNAs (lncRNAs) have been recently found to influence the progression and initiation of pancreatic cancer. MACC1-AS1, LINC00976, LINC00462, LINC01559, HOXA-AS2, LINC00152, TP73-AS1, XIST, SNHG12, LUCAT1, and UCA1 are among the oncogenic lncRNAs in pancreatic cancer. On the other hand, LINC01111, LINC01963, DGCR5, MEG3, GAS5, and LINC00261 are among tumor suppressor lncRNAs in this tissue. In the current review, we summarize the roles of these two classes of lncRNAs in pancreatic cancer and discuss their potential as attractive diagnostic and prognostic biomarkers for pancreatic cancer. We also identified that the low expression of MEG3, LINC01963, and LINC00261 and the high expression of MACC1-AS1, LINC00462, LINC01559, and UCA1 were significantly correlated with worse survival in pancreatic cancer patients. Further research on these lncRNAs will provide new clues that could potentially improve the early diagnosis, prognostic prediction, and personalized treatments of patients with pancreatic cancer.

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GOST |
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GOST Copy
Ghafouri-Fard S. et al. LncRNAs: Novel Biomarkers for Pancreatic Cancer // Biomolecules. 2021. Vol. 11. No. 11. p. 1665.
GOST all authors (up to 50) Copy
Ghafouri-Fard S., Fathi M., Zhai T., Taheri M., Dong P. LncRNAs: Novel Biomarkers for Pancreatic Cancer // Biomolecules. 2021. Vol. 11. No. 11. p. 1665.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3390/biom11111665
UR - https://doi.org/10.3390%2Fbiom11111665
TI - LncRNAs: Novel Biomarkers for Pancreatic Cancer
T2 - Biomolecules
AU - Fathi, Mohadeseh
AU - Ghafouri-Fard, Soudeh
AU - Zhai, Tianyue
AU - Taheri, Mohammad
AU - Dong, Peixin
PY - 2021
DA - 2021/11/10 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1665
IS - 11
VL - 11
PMID - 34827663
SN - 2218-273X
ER -
BibTex |
Cite this
BibTex Copy
@article{2021_Ghafouri-Fard
author = {Mohadeseh Fathi and Soudeh Ghafouri-Fard and Tianyue Zhai and Mohammad Taheri and Peixin Dong},
title = {LncRNAs: Novel Biomarkers for Pancreatic Cancer},
journal = {Biomolecules},
year = {2021},
volume = {11},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {nov},
url = {https://doi.org/10.3390%2Fbiom11111665},
number = {11},
pages = {1665},
doi = {10.3390/biom11111665}
}
MLA
Cite this
MLA Copy
Ghafouri-Fard, Soudeh, et al. “LncRNAs: Novel Biomarkers for Pancreatic Cancer.” Biomolecules, vol. 11, no. 11, Nov. 2021, p. 1665. https://doi.org/10.3390%2Fbiom11111665.
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