Open Access
Biomedicines, volume 9, issue 7, pages 802
Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques
Akhmedov Shamil
1
,
Afanasyev Sergey
1
,
Trusova Marina
2
,
Rogovskaya Yulia
1
,
Grakova Elena
1
,
Kopeva Kristina
1
,
Carreon Paz Rosa Karen
3
,
Balakin Sascha
3
,
Wiesmann Hans Peter
4
,
Opitz Jörg
3
,
Kruppke Benjamin
4
,
Beshchasna Natalia
3
,
Popov Sergey
1
3
Fraunhofer Institute for Ceramic Technologies and Systems IKTS, 01109 Dresden, Germany
|
Publication type: Journal Article
Publication date: 2021-07-12
PubMed ID:
34356866
General Biochemistry, Genetics and Molecular Biology
Medicine (miscellaneous)
Abstract
Atherosclerosis, a systematic degenerative disease related to the buildup of plaques in human vessels, remains the major cause of morbidity in the field of cardiovascular health problems, which are the number one cause of death globally. Novel atheroprotective HDL-mimicking chemically modified carbon-coated iron nanoparticles (Fe@C NPs) were produced by gas-phase synthesis and modified with organic functional groups of a lipophilic nature. Modified and non-modified Fe@C NPs, immobilized with polycaprolactone on stainless steel, showed high cytocompatibility in human endothelial cell culture. Furthermore, after ex vivo treatment of native atherosclerotic plaques obtained during open carotid endarterectomy surgery, Fe@C NPs penetrated the inner structures and caused structural changes of atherosclerotic plaques, depending on the period of implantation in Wistar rats, serving as a natural bioreactor. The high biocompatibility of the Fe@C NPs shows great potential in the treatment of atherosclerosis disease as an active substance of stent coatings to prevent restenosis and the formation of atherosclerotic plaques.
Citations by journals
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1
2
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Biomedicines
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Biomedicines
2 publications, 28.57%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
2 publications, 28.57%
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Small
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Small
1 publication, 14.29%
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Nano Research
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Nano Research
1 publication, 14.29%
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BioNanoScience
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BioNanoScience
1 publication, 14.29%
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1
2
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Citations by publishers
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1
2
3
4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 57.14%
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Springer Nature
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Springer Nature
2 publications, 28.57%
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Wiley
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Wiley
1 publication, 14.29%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Akhmedov S. et al. Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques // Biomedicines. 2021. Vol. 9. No. 7. p. 802.
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Akhmedov S., Afanasyev S., Trusova M., Postnikov P. S., Rogovskaya Y., Grakova E., Kopeva K., Carreon Paz R. K., Balakin S., Wiesmann H. P., Opitz J., Kruppke B., Beshchasna N., Popov S. Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques // Biomedicines. 2021. Vol. 9. No. 7. p. 802.
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TY - JOUR
DO - 10.3390/biomedicines9070802
UR - https://doi.org/10.3390%2Fbiomedicines9070802
TI - Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques
T2 - Biomedicines
AU - Akhmedov, Shamil
AU - Afanasyev, Sergey
AU - Trusova, Marina
AU - Rogovskaya, Yulia
AU - Carreon Paz, Rosa Karen
AU - Wiesmann, Hans Peter
AU - Beshchasna, Natalia
AU - Popov, Sergey
AU - Postnikov, Pavel S.
AU - Grakova, Elena
AU - Kopeva, Kristina
AU - Balakin, Sascha
AU - Opitz, Jörg
AU - Kruppke, Benjamin
PY - 2021
DA - 2021/07/12 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 802
IS - 7
VL - 9
PMID - 34356866
SN - 2227-9059
ER -
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@article{2021_Akhmedov,
author = {Shamil Akhmedov and Sergey Afanasyev and Marina Trusova and Yulia Rogovskaya and Rosa Karen Carreon Paz and Hans Peter Wiesmann and Natalia Beshchasna and Sergey Popov and Pavel S. Postnikov and Elena Grakova and Kristina Kopeva and Sascha Balakin and Jörg Opitz and Benjamin Kruppke},
title = {Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques},
journal = {Biomedicines},
year = {2021},
volume = {9},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jul},
url = {https://doi.org/10.3390%2Fbiomedicines9070802},
number = {7},
pages = {802},
doi = {10.3390/biomedicines9070802}
}
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MLA
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Akhmedov, Shamil, et al. “Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques.” Biomedicines, vol. 9, no. 7, Jul. 2021, p. 802. https://doi.org/10.3390%2Fbiomedicines9070802.