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Cancers, volume 12, issue 2, pages 269

Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment

Semmler Marie Luise 1
Schäfer Mirijam 1
Bernhardt Thoralf 1
Fischer Tobias 1
Witzke Katharina 3
Seebauer Christian 3
Rebl Henrike 4
Grambow Eberhard 5
Vollmar Brigitte 5
Nebe J Barbara 4
Metelmann Hans-Robert 3
von Woedtke Thomas 2
Emmert Steffen 1
Boeckmann Lars 1
1
 
Clinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, Germany
2
 
ZIK plasmatis, Leibniz-Institute for Plasma Science and Technology (INP Greifswald), 17489 Greifswald, Germany
3
 
Oral & Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, 17489 Greifswald, Germany
4
 
Department of Cell Biology, University Medical Center Rostock, 18057 Rostock, Germany
5
 
Institute for Experimental Surgery, Rostock University Medical Center, 18057 Rostock, Germany
Publication typeJournal Article
Publication date2020-01-22
Journal: Cancers
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor5.2
ISSN20726694
Cancer Research
Oncology
Abstract
Recently, the potential use of cold atmospheric pressure plasma (CAP) in cancer treatment has gained increasing interest. Especially the enhanced selective killing of tumor cells compared to normal cells has prompted researchers to elucidate the molecular mechanisms for the efficacy of CAP in cancer treatment. This review summarizes the current understanding of how CAP triggers intracellular pathways that induce growth inhibition or cell death. We discuss what factors may contribute to the potential selectivity of CAP towards cancer cells compared to their non-malignant counterparts. Furthermore, the potential of CAP to trigger an immune response is briefly discussed. Finally, this overview demonstrates how these concepts bear first fruits in clinical applications applying CAP treatment in head and neck squamous cell cancer as well as actinic keratosis. Although significant progress towards understanding the underlying mechanisms regarding the efficacy of CAP in cancer treatment has been made, much still needs to be done with respect to different treatment conditions and comparison of malignant and non-malignant cells of the same cell type and same donor. Furthermore, clinical pilot studies and the assessment of systemic effects will be of tremendous importance towards bringing this innovative technology into clinical practice.

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GOST Copy
Semmler M. L. et al. Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment // Cancers. 2020. Vol. 12. No. 2. p. 269.
GOST all authors (up to 50) Copy
Semmler M. L., Bekeschus S., Schäfer M., Bernhardt T., Fischer T., Witzke K., Seebauer C., Rebl H., Grambow E., Vollmar B., Nebe J. B., Metelmann H., von Woedtke T., Emmert S., Boeckmann L. Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment // Cancers. 2020. Vol. 12. No. 2. p. 269.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/cancers12020269
UR - https://doi.org/10.3390%2Fcancers12020269
TI - Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment
T2 - Cancers
AU - Semmler, Marie Luise
AU - Schäfer, Mirijam
AU - Bernhardt, Thoralf
AU - Fischer, Tobias
AU - Witzke, Katharina
AU - Seebauer, Christian
AU - Rebl, Henrike
AU - Grambow, Eberhard
AU - Vollmar, Brigitte
AU - Bekeschus, Sander
AU - Nebe, J Barbara
AU - Metelmann, Hans-Robert
AU - von Woedtke, Thomas
AU - Emmert, Steffen
AU - Boeckmann, Lars
PY - 2020
DA - 2020/01/22 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 269
IS - 2
VL - 12
PMID - 31979114
SN - 2072-6694
ER -
BibTex |
Cite this
BibTex Copy
@article{2020_Semmler
author = {Marie Luise Semmler and Mirijam Schäfer and Thoralf Bernhardt and Tobias Fischer and Katharina Witzke and Christian Seebauer and Henrike Rebl and Eberhard Grambow and Brigitte Vollmar and Sander Bekeschus and J Barbara Nebe and Hans-Robert Metelmann and Thomas von Woedtke and Steffen Emmert and Lars Boeckmann},
title = {Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment},
journal = {Cancers},
year = {2020},
volume = {12},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jan},
url = {https://doi.org/10.3390%2Fcancers12020269},
number = {2},
pages = {269},
doi = {10.3390/cancers12020269}
}
MLA
Cite this
MLA Copy
Semmler, Marie Luise, et al. “Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment.” Cancers, vol. 12, no. 2, Jan. 2020, p. 269. https://doi.org/10.3390%2Fcancers12020269.
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