Open Access

Cancers, volume 5, issue 4, pages 462-490

Regulatory Roles for Long ncRNA and mRNA

Karapetyan Armen ¹

Buiting Coen ¹

Kuiper Renske ¹

Coolen Marcel ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences (NCMLS), Radboud University Nijmegen Medical Centre, P.O. Box 9101, Nijmegen 6500 HB, The Netherlands |

Publication type: Journal Article

Publication date: 2013-04-26

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Cancers

Quartile SCImago

Quartile WOS

Impact factor: 5.2

ISSN: 20726694

DOI: 10.3390/cancers5020462

Copy DOI

PubMed ID: 24216986

Cancer Research

Oncology

Abstract

Recent advances in high-throughput sequencing technology have identified the transcription of a much larger portion of the genome than previously anticipated. Especially in the context of cancer it has become clear that aberrant transcription of both protein-coding and long non-coding RNAs (lncRNAs) are frequent events. The current dogma of RNA function describes mRNA to be responsible for the synthesis of proteins, whereas non-coding RNA can have regulatory or epigenetic functions. However, this distinction between protein coding and regulatory ability of transcripts may not be that strict. Here, we review the increasing body of evidence for the existence of multifunctional RNAs that have both protein-coding and trans-regulatory roles. Moreover, we demonstrate that coding transcripts bind to components of the Polycomb Repressor Complex 2 (PRC2) with similar affinities as non-coding transcripts, revealing potential epigenetic regulation by mRNAs. We hypothesize that studies on the regulatory ability of disease-associated mRNAs will form an important new field of research.

By date By citations

Citations by journals

	1 2 3
Genes	Genes, 3, 3.95% Genes 3 publications, 3.95%
Molecular Biology	Molecular Biology, 2, 2.63% Molecular Biology 2 publications, 2.63%
Oncotarget	Oncotarget, 2, 2.63% Oncotarget 2 publications, 2.63%
Non-coding RNA	Non-coding RNA, 2, 2.63% Non-coding RNA 2 publications, 2.63%
Molecular Neurobiology	Molecular Neurobiology, 2, 2.63% Molecular Neurobiology 2 publications, 2.63%
BMC Genomics	BMC Genomics, 2, 2.63% BMC Genomics 2 publications, 2.63%
Cell Death and Disease	Cell Death and Disease, 2, 2.63% Cell Death and Disease 2 publications, 2.63%
PLoS ONE	PLoS ONE, 2, 2.63% PLoS ONE 2 publications, 2.63%
Russian Journal of Genetics	Russian Journal of Genetics, 2, 2.63% Russian Journal of Genetics 2 publications, 2.63%
RNA Biology	RNA Biology, 2, 2.63% RNA Biology 2 publications, 2.63%
Briefings in Bioinformatics	Briefings in Bioinformatics, 2, 2.63% Briefings in Bioinformatics 2 publications, 2.63%
Nucleic Acids Research	Nucleic Acids Research, 2, 2.63% Nucleic Acids Research 2 publications, 2.63%
Communications Biology	Communications Biology, 1, 1.32% Communications Biology 1 publication, 1.32%
Drug Metabolism and Disposition	Drug Metabolism and Disposition, 1, 1.32% Drug Metabolism and Disposition 1 publication, 1.32%
Biochemistry and Cell Biology	Biochemistry and Cell Biology, 1, 1.32% Biochemistry and Cell Biology 1 publication, 1.32%
Bioscience Reports	Bioscience Reports, 1, 1.32% Bioscience Reports 1 publication, 1.32%
Technology in Cancer Research and Treatment	Technology in Cancer Research and Treatment, 1, 1.32% Technology in Cancer Research and Treatment 1 publication, 1.32%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 1.32% International Journal of Molecular Sciences 1 publication, 1.32%
Cancers	Cancers, 1, 1.32% Cancers 1 publication, 1.32%
Frontiers in Physiology	Frontiers in Physiology, 1, 1.32% Frontiers in Physiology 1 publication, 1.32%
Frontiers in Genetics	Frontiers in Genetics, 1, 1.32% Frontiers in Genetics 1 publication, 1.32%
BMC Cancer	BMC Cancer, 1, 1.32% BMC Cancer 1 publication, 1.32%
Molecular Genetics and Genomics	Molecular Genetics and Genomics, 1, 1.32% Molecular Genetics and Genomics 1 publication, 1.32%
In Vitro Cellular and Developmental Biology - Animal	In Vitro Cellular and Developmental Biology - Animal, 1, 1.32% In Vitro Cellular and Developmental Biology - Animal 1 publication, 1.32%
BMC Medical Genomics	BMC Medical Genomics, 1, 1.32% BMC Medical Genomics 1 publication, 1.32%
Molecular and Cellular Biochemistry	Molecular and Cellular Biochemistry, 1, 1.32% Molecular and Cellular Biochemistry 1 publication, 1.32%
Oncogene	Oncogene, 1, 1.32% Oncogene 1 publication, 1.32%
Chromosome Research	Chromosome Research, 1, 1.32% Chromosome Research 1 publication, 1.32%
IUBMB Life	IUBMB Life, 1, 1.32% IUBMB Life 1 publication, 1.32%
	1 2 3

Citations by publishers

	2 4 6 8 10 12 14 16 18
Springer Nature	Springer Nature, 18, 23.68% Springer Nature 18 publications, 23.68%
Elsevier	Elsevier, 11, 14.47% Elsevier 11 publications, 14.47%
Wiley	Wiley, 8, 10.53% Wiley 8 publications, 10.53%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 7, 9.21% Multidisciplinary Digital Publishing Institute (MDPI) 7 publications, 9.21%
Pleiades Publishing	Pleiades Publishing, 5, 6.58% Pleiades Publishing 5 publications, 6.58%
Oxford University Press	Oxford University Press, 4, 5.26% Oxford University Press 4 publications, 5.26%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 3, 3.95% Public Library of Science (PLoS) 3 publications, 3.95%
Taylor & Francis	Taylor & Francis, 3, 3.95% Taylor & Francis 3 publications, 3.95%
Impact Journals	Impact Journals, 2, 2.63% Impact Journals 2 publications, 2.63%
Frontiers Media S.A.	Frontiers Media S.A., 2, 2.63% Frontiers Media S.A. 2 publications, 2.63%
American Society for Pharmacology and Experimental Therapeutics	American Society for Pharmacology and Experimental Therapeutics, 1, 1.32% American Society for Pharmacology and Experimental Therapeutics 1 publication, 1.32%
Canadian Science Publishing	Canadian Science Publishing, 1, 1.32% Canadian Science Publishing 1 publication, 1.32%
SAGE	SAGE, 1, 1.32% SAGE 1 publication, 1.32%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 1, 1.32% American Society for Biochemistry and Molecular Biology 1 publication, 1.32%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 1.32% American Chemical Society (ACS) 1 publication, 1.32%
Onkoloski Institut Ljubljana/Institute of Oncology Ljubljana	Onkoloski Institut Ljubljana/Institute of Oncology Ljubljana, 1, 1.32% Onkoloski Institut Ljubljana/Institute of Oncology Ljubljana 1 publication, 1.32%
Hindawi Limited	Hindawi Limited, 1, 1.32% Hindawi Limited 1 publication, 1.32%
	2 4 6 8 10 12 14 16 18

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
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Karapetyan A. et al. Regulatory Roles for Long ncRNA and mRNA // Cancers. 2013. Vol. 5. No. 4. pp. 462-490.

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Karapetyan A., Buiting C., Kuiper R., Coolen M. Regulatory Roles for Long ncRNA and mRNA // Cancers. 2013. Vol. 5. No. 4. pp. 462-490.

RIS |

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RIS Copy

TY - JOUR

DO - 10.3390/cancers5020462

UR - https://doi.org/10.3390%2Fcancers5020462

TI - Regulatory Roles for Long ncRNA and mRNA

T2 - Cancers

AU - Karapetyan, Armen

AU - Buiting, Coen

AU - Kuiper, Renske

AU - Coolen, Marcel

PY - 2013

DA - 2013/04/26 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 462-490

IS - 4

VL - 5

PMID - 24216986

SN - 2072-6694

ER -

BibTex |

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BibTex Copy

@article{2013_Karapetyan,

author = {Armen Karapetyan and Coen Buiting and Renske Kuiper and Marcel Coolen},

title = {Regulatory Roles for Long ncRNA and mRNA},

journal = {Cancers},

year = {2013},

volume = {5},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {apr},

url = {https://doi.org/10.3390%2Fcancers5020462},

number = {4},

pages = {462--490},

doi = {10.3390/cancers5020462}

}

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MLA Copy

Karapetyan, Armen, et al. “Regulatory Roles for Long ncRNA and mRNA.” Cancers, vol. 5, no. 4, Apr. 2013, pp. 462-490. https://doi.org/10.3390%2Fcancers5020462.

Found error?

Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

Cancers

Quartile SCImago

Quartile WOS

Impact factor

5.2

ISSN

20726694 (Print)