Open Access
Cells, volume 8, issue 8, pages 869
The Nucleolus: A Multiphase Condensate Balancing Ribosome Synthesis and Translational Capacity in Health, Aging and Ribosomopathies
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Center for Proteomics and Molecular Therapeutics, Rosalind Franklin University of Medicine & Science, North Chicago, IL 60064, USA
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4
Center for Cancer Cell Biology Immunology and Infection, Rosalind Franklin University of Medicine & Science, North Chicago, IL 60064, USA
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Publication type: Journal Article
Publication date: 2019-08-10
PubMed ID:
31405125
General Medicine
Abstract
The nucleolus is the largest membrane-less structure in the eukaryotic nucleus. It is involved in the biogenesis of ribosomes, essential macromolecular machines responsible for synthesizing all proteins required by the cell. The assembly of ribosomes is evolutionarily conserved and is the most energy-consuming cellular process needed for cell growth, proliferation, and homeostasis. Despite the significance of this process, the intricate pathophysiological relationship between the nucleolus and protein synthesis has only recently begun to emerge. Here, we provide perspective on new principles governing nucleolar formation and the resulting multiphase organization driven by liquid-liquid phase separation. With recent advances in the structural analysis of ribosome formation, we highlight the current understanding of the step-wise assembly of pre-ribosomal subunits and the quality control required for proper function. Finally, we address how aging affects ribosome genesis and how genetic defects in ribosome formation cause ribosomopathies, complex diseases with a predisposition to cancer.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Correll C. C. et al. The Nucleolus: A Multiphase Condensate Balancing Ribosome Synthesis and Translational Capacity in Health, Aging and Ribosomopathies // Cells. 2019. Vol. 8. No. 8. p. 869.
GOST all authors (up to 50)
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Correll C. C., Bartek J., DUNDR M. The Nucleolus: A Multiphase Condensate Balancing Ribosome Synthesis and Translational Capacity in Health, Aging and Ribosomopathies // Cells. 2019. Vol. 8. No. 8. p. 869.
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RIS
Copy
TY - JOUR
DO - 10.3390/cells8080869
UR - https://doi.org/10.3390%2Fcells8080869
TI - The Nucleolus: A Multiphase Condensate Balancing Ribosome Synthesis and Translational Capacity in Health, Aging and Ribosomopathies
T2 - Cells
AU - Correll, Carl C
AU - Bartek, Jiri
AU - DUNDR, Miroslav
PY - 2019
DA - 2019/08/10 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 869
IS - 8
VL - 8
PMID - 31405125
SN - 2073-4409
ER -
Cite this
BibTex
Copy
@article{2019_Correll
author = {Carl C Correll and Jiri Bartek and Miroslav DUNDR},
title = {The Nucleolus: A Multiphase Condensate Balancing Ribosome Synthesis and Translational Capacity in Health, Aging and Ribosomopathies},
journal = {Cells},
year = {2019},
volume = {8},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {aug},
url = {https://doi.org/10.3390%2Fcells8080869},
number = {8},
pages = {869},
doi = {10.3390/cells8080869}
}
Cite this
MLA
Copy
Correll, Carl C., et al. “The Nucleolus: A Multiphase Condensate Balancing Ribosome Synthesis and Translational Capacity in Health, Aging and Ribosomopathies.” Cells, vol. 8, no. 8, Aug. 2019, p. 869. https://doi.org/10.3390%2Fcells8080869.