Open Access
Genes, volume 6, issue 2, pages 163-184
Nuclear Export of Messenger RNA
1
Biomolecular Networks Laboratories, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan
|
2
Department of Biochemistry, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
|
Publication type: Journal Article
Publication date: 2015-03-31
PubMed ID:
25836925
Genetics
Genetics (clinical)
Abstract
Transport of messenger RNA (mRNA) from the nucleus to the cytoplasm is an essential step of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of processing steps, including capping at the 5' ends, splicing and cleavage/polyadenylation at the 3' ends. During this process, the mRNA associates with a wide variety of proteins, forming a messenger ribonucleoprotein (mRNP) particle. Association with factors involved in nuclear export also occurs during transcription and processing, and thus nuclear export is fully integrated into mRNA maturation. The coupling between mRNA maturation and nuclear export is an important mechanism for providing only fully functional and competent mRNA to the cytoplasmic translational machinery, thereby ensuring accuracy and swiftness of gene expression. This review describes the molecular mechanism of nuclear mRNA export mediated by the principal transport factors, including Tap-p15 and the TREX complex.
Citations by journals
1
2
3
4
5
|
|
Nucleic Acids Research
|
Nucleic Acids Research
5 publications, 6.58%
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
3 publications, 3.95%
|
Biochemical Society Transactions
|
Biochemical Society Transactions
2 publications, 2.63%
|
Wiley interdisciplinary reviews. RNA
|
Wiley interdisciplinary reviews. RNA
2 publications, 2.63%
|
Cells
|
Cells
2 publications, 2.63%
|
Viruses
|
Viruses
2 publications, 2.63%
|
Scientific Reports
|
Scientific Reports
2 publications, 2.63%
|
PLoS Genetics
|
PLoS Genetics
2 publications, 2.63%
|
Journal of Biological Chemistry
|
Journal of Biological Chemistry
2 publications, 2.63%
|
Journal of Molecular Biology
|
Journal of Molecular Biology
2 publications, 2.63%
|
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
|
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
2 publications, 2.63%
|
Molecular Microbiology
|
Molecular Microbiology
2 publications, 2.63%
|
Biomedicines
|
Biomedicines
1 publication, 1.32%
|
Frontiers in Immunology
|
Frontiers in Immunology
1 publication, 1.32%
|
Journal of Cell Science
|
Journal of Cell Science
1 publication, 1.32%
|
Applied Microbiology and Biotechnology
|
Applied Microbiology and Biotechnology
1 publication, 1.32%
|
Biochemical Journal
|
Biochemical Journal
1 publication, 1.32%
|
Open Biology
|
Open Biology
1 publication, 1.32%
|
Oncology Letters
|
Oncology Letters
1 publication, 1.32%
|
Frontiers in Endocrinology
|
Frontiers in Endocrinology
1 publication, 1.32%
|
Frontiers in Cellular and Infection Microbiology
|
Frontiers in Cellular and Infection Microbiology
1 publication, 1.32%
|
Acta neuropathologica communications
|
Acta neuropathologica communications
1 publication, 1.32%
|
Nature Cell Biology
|
Nature Cell Biology
1 publication, 1.32%
|
Cell Death and Disease
|
Cell Death and Disease
1 publication, 1.32%
|
Seminars in Cell and Developmental Biology
|
Seminars in Cell and Developmental Biology
1 publication, 1.32%
|
PLoS Computational Biology
|
PLoS Computational Biology
1 publication, 1.32%
|
Parasitology International
|
Parasitology International
1 publication, 1.32%
|
Virus Research
|
Virus Research
1 publication, 1.32%
|
International Journal of Biochemistry and Cell Biology
|
International Journal of Biochemistry and Cell Biology
1 publication, 1.32%
|
1
2
3
4
5
|
Citations by publishers
2
4
6
8
10
12
|
|
Elsevier
|
Elsevier
12 publications, 15.79%
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
9 publications, 11.84%
|
Springer Nature
|
Springer Nature
9 publications, 11.84%
|
Wiley
|
Wiley
8 publications, 10.53%
|
Oxford University Press
|
Oxford University Press
5 publications, 6.58%
|
Frontiers Media S.A.
|
Frontiers Media S.A.
3 publications, 3.95%
|
Portland Press
|
Portland Press
3 publications, 3.95%
|
Public Library of Science (PLoS)
|
Public Library of Science (PLoS)
3 publications, 3.95%
|
American Society for Biochemistry and Molecular Biology
|
American Society for Biochemistry and Molecular Biology
2 publications, 2.63%
|
Taylor & Francis
|
Taylor & Francis
2 publications, 2.63%
|
The Company of Biologists
|
The Company of Biologists
1 publication, 1.32%
|
The Royal Society
|
The Royal Society
1 publication, 1.32%
|
Spandidos Publications
|
Spandidos Publications
1 publication, 1.32%
|
Social Science Electronic Publishing
|
Social Science Electronic Publishing
1 publication, 1.32%
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
1 publication, 1.32%
|
Pleiades Publishing
|
Pleiades Publishing
1 publication, 1.32%
|
Genetics Society of America
|
Genetics Society of America
1 publication, 1.32%
|
Cold Spring Harbor Laboratory
|
Cold Spring Harbor Laboratory
1 publication, 1.32%
|
Society for Neuroscience
|
Society for Neuroscience
1 publication, 1.32%
|
2
4
6
8
10
12
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2015,2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","","","",""],"datasets":[{"label":"Citations number","data":[2,6,7,10,10,8,13,8,7,5],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["2.63","7.89","9.21","13.16","13.16","10.53","17.11","10.53","9.21","6.58"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Nucleic Acids Research","International Journal of Molecular Sciences","Biochemical Society Transactions","Wiley interdisciplinary reviews. RNA","Cells","Viruses","Scientific Reports","PLoS Genetics","Journal of Biological Chemistry","Journal of Molecular Biology","Biochimica et Biophysica Acta - Gene Regulatory Mechanisms","Molecular Microbiology","Biomedicines","Frontiers in Immunology","Journal of Cell Science","Applied Microbiology and Biotechnology","Biochemical Journal","Open Biology","Oncology Letters","Frontiers in Endocrinology","Frontiers in Cellular and Infection Microbiology","Acta neuropathologica communications","Nature Cell Biology","Cell Death and Disease","Seminars in Cell and Developmental Biology","PLoS Computational Biology","Parasitology International","Virus Research","International Journal of Biochemistry and Cell Biology"],"ids":[23904,14627,10198,8123,25293,2455,13767,785,19451,19701,14531,2811,24421,1699,21886,17681,15459,13367,9773,19896,21709,479,22534,25236,9325,23198,28,24704,11801],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/nUqNrP9GnM1t0BrAIXp1LBodjU8aIJ2Fk4pLfGhZ_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/ko5EaisKGm66J1hHXtfEgVEeeWb9uOcMofpNuf0a_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/nUqNrP9GnM1t0BrAIXp1LBodjU8aIJ2Fk4pLfGhZ_medium.webp","\/storage\/images\/resized\/BHBStD1OkQqtKFRRjS5njgNe7bXCAEgaDQVK7GTA_medium.webp","\/storage\/images\/resized\/8zKfOwdd5XirYzTQfqwp7U8IEQc8ckIOjyYQSBkk_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[5,3,2,2,2,2,2,2,2,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[6.58,3.95,2.63,2.63,2.63,2.63,2.63,2.63,2.63,2.63,2.63,2.63,1.32,1.32,1.32,1.32,1.32,1.32,1.32,1.32,1.32,1.32,1.32,1.32,1.32,1.32,1.32,1.32,1.32],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Multidisciplinary Digital Publishing Institute (MDPI)","Springer Nature","Wiley","Oxford University Press","Frontiers Media S.A.","Portland Press","Public Library of Science (PLoS)","American Society for Biochemistry and Molecular Biology","Taylor & Francis","The Company of Biologists","The Royal Society","Spandidos Publications","Social Science Electronic Publishing","American Chemical Society (ACS)","Pleiades Publishing","Genetics Society of America","Cold Spring Harbor Laboratory","Society for Neuroscience"],"ids":[17,202,8,11,19,208,801,344,2090,18,872,259,1097,7090,40,101,3356,6909,3127],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/nUqNrP9GnM1t0BrAIXp1LBodjU8aIJ2Fk4pLfGhZ_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/ko5EaisKGm66J1hHXtfEgVEeeWb9uOcMofpNuf0a_medium.webp","\/storage\/images\/resized\/BHBStD1OkQqtKFRRjS5njgNe7bXCAEgaDQVK7GTA_medium.webp","\/storage\/images\/resized\/8zKfOwdd5XirYzTQfqwp7U8IEQc8ckIOjyYQSBkk_medium.webp","\/storage\/images\/resized\/VB6UIgqsyDBgrsTtqT4C2ImAHGDidVrMrprJV4LS_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/9EVpRifnnUJt6oHGY5GfsfSXTEz5wzbdgnZqiF5m_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/oK3sRIFs7jTQfHhJn9GNyct1rmZrCIj9Rn5x9It5_medium.webp"],"datasets":[{"label":"","data":[12,9,9,8,5,3,3,3,2,2,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[15.79,11.84,11.84,10.53,6.58,3.95,3.95,3.95,2.63,2.63,1.32,1.32,1.32,1.32,1.32,1.32,1.32,1.32,1.32],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/genes6020163
UR - https://doi.org/10.3390%2Fgenes6020163
TI - Nuclear Export of Messenger RNA
T2 - Genes
AU - Katahira, Jun
PY - 2015
DA - 2015/03/31 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 163-184
IS - 2
VL - 6
PMID - 25836925
SN - 2073-4425
ER -
Cite this
BibTex
Copy
@article{2015_Katahira
author = {Jun Katahira},
title = {Nuclear Export of Messenger RNA},
journal = {Genes},
year = {2015},
volume = {6},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {mar},
url = {https://doi.org/10.3390%2Fgenes6020163},
number = {2},
pages = {163--184},
doi = {10.3390/genes6020163}
}
Cite this
MLA
Copy
Katahira, Jun. “Nuclear Export of Messenger RNA.” Genes, vol. 6, no. 2, Mar. 2015, pp. 163-184. https://doi.org/10.3390%2Fgenes6020163.