Open Access
Genes, volume 9, issue 7, pages 356
An Evolutionary Mechanism for the Generation of Competing RNA Structures Associated with Mutually Exclusive Exons
Ivanov Timofei
1
,
Pervouchine Dmitri D
1, 2, 3
Publication type: Journal Article
Publication date: 2018-07-17
PubMed ID:
30018239
Genetics
Genetics (clinical)
Abstract
Alternative splicing is a commonly-used mechanism of diversifying gene products. Mutually exclusive exons (MXE) represent a particular type of alternative splicing, in which one and only one exon from an array is included in the mature RNA. A number of genes with MXE do so by using a mechanism that depends on RNA structure. Transcripts of these genes contain multiple sites called selector sequences that are all complementary to a regulatory element called the docking site; only one of the competing base pairings can form at a time, which exposes one exon from the cluster to the spliceosome. MXE tend to have similar lengths and sequence content and are believed to originate through tandem genomic duplications. Here, we report that pre-mRNAs of this class of exons have an increased capacity to fold into competing secondary structures. We propose an evolutionary mechanism for the generation of such structures via duplications that affect not only exons, but also their adjacent introns with stem-loop structures. If one of the two arms of a stem-loop is duplicated, it will generate two selector sequences that compete for the same docking site, a pattern that is associated with MXE splicing. A similar partial duplication of two independent stem-loops produces a pattern that is consistent with the so-called bidirectional pairing model. These models explain why tandem exon duplications frequently result in mutually exclusive splicing.
Citations by journals
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1
2
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Nucleic Acids Research
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Nucleic Acids Research
2 publications, 15.38%
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Genes
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Genes
1 publication, 7.69%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 7.69%
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Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
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Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
1 publication, 7.69%
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Cell Reports
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Cell Reports
1 publication, 7.69%
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Wiley interdisciplinary reviews. RNA
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Wiley interdisciplinary reviews. RNA
1 publication, 7.69%
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Science advances
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Science advances
1 publication, 7.69%
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RNA
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RNA
1 publication, 7.69%
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Acta Naturae
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Acta Naturae, 1, 7.69%
Acta Naturae
1 publication, 7.69%
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NAR Genomics and Bioinformatics
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NAR Genomics and Bioinformatics
1 publication, 7.69%
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1
2
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Citations by publishers
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1
2
3
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Oxford University Press
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Oxford University Press
3 publications, 23.08%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 15.38%
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Elsevier
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Elsevier
2 publications, 15.38%
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Wiley
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Wiley
1 publication, 7.69%
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American Association for the Advancement of Science (AAAS)
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American Association for the Advancement of Science (AAAS)
1 publication, 7.69%
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Cold Spring Harbor Laboratory
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Cold Spring Harbor Laboratory
1 publication, 7.69%
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Acta Naturae Ltd
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Acta Naturae Ltd, 1, 7.69%
Acta Naturae Ltd
1 publication, 7.69%
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1
2
3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Ivanov T. et al. An Evolutionary Mechanism for the Generation of Competing RNA Structures Associated with Mutually Exclusive Exons // Genes. 2018. Vol. 9. No. 7. p. 356.
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Ivanov T., Pervouchine D. D. An Evolutionary Mechanism for the Generation of Competing RNA Structures Associated with Mutually Exclusive Exons // Genes. 2018. Vol. 9. No. 7. p. 356.
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TY - JOUR
DO - 10.3390/genes9070356
UR - https://doi.org/10.3390%2Fgenes9070356
TI - An Evolutionary Mechanism for the Generation of Competing RNA Structures Associated with Mutually Exclusive Exons
T2 - Genes
AU - Ivanov, Timofei
AU - Pervouchine, Dmitri D
PY - 2018
DA - 2018/07/17 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 356
IS - 7
VL - 9
PMID - 30018239
SN - 2073-4425
ER -
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@article{2018_Ivanov,
author = {Timofei Ivanov and Dmitri D Pervouchine},
title = {An Evolutionary Mechanism for the Generation of Competing RNA Structures Associated with Mutually Exclusive Exons},
journal = {Genes},
year = {2018},
volume = {9},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jul},
url = {https://doi.org/10.3390%2Fgenes9070356},
number = {7},
pages = {356},
doi = {10.3390/genes9070356}
}
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Ivanov, Timofei, et al. “An Evolutionary Mechanism for the Generation of Competing RNA Structures Associated with Mutually Exclusive Exons.” Genes, vol. 9, no. 7, Jul. 2018, p. 356. https://doi.org/10.3390%2Fgenes9070356.