Open Access
International Journal of Molecular Sciences, volume 16, issue 12, pages 6183-6201
DNA Damage: A Sensible Mediator of the Differentiation Decision in Hematopoietic Stem Cells and in Leukemia
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Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Departments of Cell Biology/Stem Cell Institute and Medicine, Albert Einstein Cancer Center and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
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Publication type: Journal Article
Publication date: 2015-03-17
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
25789504
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
In the adult, the source of functionally diverse, mature blood cells are hematopoietic stem cells, a rare population of quiescent cells that reside in the bone marrow niche. Like stem cells in other tissues, hematopoietic stem cells are defined by their ability to self-renew, in order to maintain the stem cell population for the lifetime of the organism, and to differentiate, in order to give rise to the multiple lineages of the hematopoietic system. In recent years, increasing evidence has suggested a role for the accumulation of reactive oxygen species and DNA damage in the decision for hematopoietic stem cells to exit quiescence and to differentiate. In this review, we will examine recent work supporting the idea that detection of cell stressors, such as oxidative and genetic damage, is an important mediator of cell fate decisions in hematopoietic stem cells. We will explore the benefits of such a system in avoiding the development and progression of malignancies, and in avoiding tissue exhaustion and failure. Additionally, we will discuss new work that examines the accumulation of DNA damage and replication stress in aging hematopoietic stem cells and causes us to rethink ideas of genoprotection in the bone marrow niche.
Citations by journals
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Experimental Hematology
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1 publication, 4.17%
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Scientific Reports
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1 publication, 4.17%
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Leukemia
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1 publication, 4.17%
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1 publication, 4.17%
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1 publication, 4.17%
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Genomics, Proteomics and Bioinformatics
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1 publication, 4.17%
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1 publication, 4.17%
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1 publication, 4.17%
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Radiation Research, 1, 4.17%
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1 publication, 4.17%
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1 publication, 4.17%
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1 publication, 4.17%
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Citations by publishers
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6
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Springer Nature
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Springer Nature
6 publications, 25%
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Elsevier
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Elsevier
6 publications, 25%
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Taylor & Francis
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2 publications, 8.33%
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Impact Journals
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2 publications, 8.33%
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2 publications, 8.33%
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Bentham Science
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Bentham Science
1 publication, 4.17%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 4.17%
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Radiation Research Society
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Radiation Research Society, 1, 4.17%
Radiation Research Society
1 publication, 4.17%
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Oxford University Press
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Oxford University Press
1 publication, 4.17%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Weiss C., Ito K. DNA Damage: A Sensible Mediator of the Differentiation Decision in Hematopoietic Stem Cells and in Leukemia // International Journal of Molecular Sciences. 2015. Vol. 16. No. 12. pp. 6183-6201.
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Weiss C., Ito K. DNA Damage: A Sensible Mediator of the Differentiation Decision in Hematopoietic Stem Cells and in Leukemia // International Journal of Molecular Sciences. 2015. Vol. 16. No. 12. pp. 6183-6201.
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TY - JOUR
DO - 10.3390/ijms16036183
UR - https://doi.org/10.3390%2Fijms16036183
TI - DNA Damage: A Sensible Mediator of the Differentiation Decision in Hematopoietic Stem Cells and in Leukemia
T2 - International Journal of Molecular Sciences
AU - Weiss, Cary
AU - Ito, Keisuke
PY - 2015
DA - 2015/03/17 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 6183-6201
IS - 12
VL - 16
PMID - 25789504
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2015_Weiss,
author = {Cary Weiss and Keisuke Ito},
title = {DNA Damage: A Sensible Mediator of the Differentiation Decision in Hematopoietic Stem Cells and in Leukemia},
journal = {International Journal of Molecular Sciences},
year = {2015},
volume = {16},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {mar},
url = {https://doi.org/10.3390%2Fijms16036183},
number = {12},
pages = {6183--6201},
doi = {10.3390/ijms16036183}
}
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Weiss, Cary, and Keisuke Ito. “DNA Damage: A Sensible Mediator of the Differentiation Decision in Hematopoietic Stem Cells and in Leukemia.” International Journal of Molecular Sciences, vol. 16, no. 12, Mar. 2015, pp. 6183-6201. https://doi.org/10.3390%2Fijms16036183.