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International Journal of Molecular Sciences, volume 20, issue 8, pages 1981

The Origin and Evolution of Release Factors: Implications for Translation Termination, Ribosome Rescue, and Quality Control Pathways

Burroughs A Maxwell 1
Aravind L. 1
1
 
Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Publication typeJournal Article
Publication date2019-04-23
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor5.6
ISSN16616596, 14220067
PubMed ID:  31018531
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
The evolution of release factors catalyzing the hydrolysis of the final peptidyl-tRNA bond and the release of the polypeptide from the ribosome has been a longstanding paradox. While the components of the translation apparatus are generally well-conserved across extant life, structurally unrelated release factor peptidyl hydrolases (RF-PHs) emerged in the stems of the bacterial and archaeo-eukaryotic lineages. We analyze the diversification of RF-PH domains within the broader evolutionary framework of the translation apparatus. Thus, we reconstruct the possible state of translation termination in the Last Universal Common Ancestor with possible tRNA-like terminators. Further, evolutionary trajectories of the several auxiliary release factors in ribosome quality control (RQC) and rescue pathways point to multiple independent solutions to this problem and frequent transfers between superkingdoms including the recently characterized ArfT, which is more widely distributed across life than previously appreciated. The eukaryotic RQC system was pieced together from components with disparate provenance, which include the long-sought-after Vms1/ANKZF1 RF-PH of bacterial origin. We also uncover an under-appreciated evolutionary driver of innovation in rescue pathways: effectors deployed in biological conflicts that target the ribosome. At least three rescue pathways (centered on the prfH/RFH, baeRF-1, and C12orf65 RF-PH domains), were likely innovated in response to such conflicts.

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Burroughs A. M., Aravind L. The Origin and Evolution of Release Factors: Implications for Translation Termination, Ribosome Rescue, and Quality Control Pathways // International Journal of Molecular Sciences. 2019. Vol. 20. No. 8. p. 1981.
GOST all authors (up to 50) Copy
Burroughs A. M., Aravind L. The Origin and Evolution of Release Factors: Implications for Translation Termination, Ribosome Rescue, and Quality Control Pathways // International Journal of Molecular Sciences. 2019. Vol. 20. No. 8. p. 1981.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/ijms20081981
UR - https://doi.org/10.3390%2Fijms20081981
TI - The Origin and Evolution of Release Factors: Implications for Translation Termination, Ribosome Rescue, and Quality Control Pathways
T2 - International Journal of Molecular Sciences
AU - Burroughs, A Maxwell
AU - Aravind, L.
PY - 2019
DA - 2019/04/23 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1981
IS - 8
VL - 20
PMID - 31018531
SN - 1661-6596
SN - 1422-0067
ER -
BibTex |
Cite this
BibTex Copy
@article{2019_Burroughs
author = {A Maxwell Burroughs and L. Aravind},
title = {The Origin and Evolution of Release Factors: Implications for Translation Termination, Ribosome Rescue, and Quality Control Pathways},
journal = {International Journal of Molecular Sciences},
year = {2019},
volume = {20},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {apr},
url = {https://doi.org/10.3390%2Fijms20081981},
number = {8},
pages = {1981},
doi = {10.3390/ijms20081981}
}
MLA
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MLA Copy
Burroughs, A. Maxwell, and L. Aravind. “The Origin and Evolution of Release Factors: Implications for Translation Termination, Ribosome Rescue, and Quality Control Pathways.” International Journal of Molecular Sciences, vol. 20, no. 8, Apr. 2019, p. 1981. https://doi.org/10.3390%2Fijms20081981.
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