Open Access
International Journal of Molecular Sciences, volume 22, issue 3, pages 1094
8q24.21 Locus: A Paradigm to Link Non-Coding RNAs, Genome Polymorphisms and Cancer
Publication type: Journal Article
Publication date: 2021-01-22
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
33499210
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
The majority of the human genome is comprised of non-protein-coding genes, but the relevance of non-coding RNAs in complex diseases has yet to be fully elucidated. One class of non-coding RNAs is long non-coding RNAs or lncRNAs, many of which have been identified to play a range of roles in transcription and translation. While the clinical importance of the majority of lncRNAs have yet to be identified, it is puzzling that a large number of disease-associated genetic variations are seen in lncRNA genes. The 8q24.21 locus is rich in lncRNAs and very few protein-coding genes are located in this region. Interestingly, the 8q24.21 region is also a hot spot for genetic variants associated with an increased risk of cancer. Research focusing on the lncRNAs in this area of the genome has indicated clinical relevance of lncRNAs in different cancers. In this review, we summarise the lncRNAs in the 8q24.21 region with respect to their role in cancer and discuss the potential impact of cancer-associated genetic polymorphisms on the function of lncRNAs in initiation and progression of cancer.
Citations by journals
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Doklady Biochemistry and Biophysics
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Doklady Biochemistry and Biophysics
1 publication, 7.14%
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Onco Therapeutics
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1 publication, 7.14%
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Frontiers in Oncology
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1 publication, 7.14%
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BMC Cancer
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1 publication, 7.14%
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iScience
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iScience
1 publication, 7.14%
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Frontiers in Genetics
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1 publication, 7.14%
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Wiley interdisciplinary reviews. RNA
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1 publication, 7.14%
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International Journal of Cancer
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1 publication, 7.14%
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Pathology Research and Practice
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1 publication, 7.14%
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1 publication, 7.14%
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Molecular Carcinogenesis
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1 publication, 7.14%
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Oncology Letters
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Oncology Letters
1 publication, 7.14%
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1
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Citations by publishers
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1
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3
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Wiley
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Wiley
3 publications, 21.43%
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Frontiers Media S.A.
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Frontiers Media S.A.
2 publications, 14.29%
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Springer Nature
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Springer Nature
2 publications, 14.29%
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Elsevier
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Elsevier
2 publications, 14.29%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 7.14%
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Begell House
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Begell House
1 publication, 7.14%
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Spandidos Publications
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Spandidos Publications
1 publication, 7.14%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Wilson C., Kanhere A. 8q24.21 Locus: A Paradigm to Link Non-Coding RNAs, Genome Polymorphisms and Cancer // International Journal of Molecular Sciences. 2021. Vol. 22. No. 3. p. 1094.
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Wilson C., Kanhere A. 8q24.21 Locus: A Paradigm to Link Non-Coding RNAs, Genome Polymorphisms and Cancer // International Journal of Molecular Sciences. 2021. Vol. 22. No. 3. p. 1094.
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TY - JOUR
DO - 10.3390/ijms22031094
UR - https://doi.org/10.3390%2Fijms22031094
TI - 8q24.21 Locus: A Paradigm to Link Non-Coding RNAs, Genome Polymorphisms and Cancer
T2 - International Journal of Molecular Sciences
AU - Wilson, Claire
AU - Kanhere, Aditi
PY - 2021
DA - 2021/01/22 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1094
IS - 3
VL - 22
PMID - 33499210
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2021_Wilson,
author = {Claire Wilson and Aditi Kanhere},
title = {8q24.21 Locus: A Paradigm to Link Non-Coding RNAs, Genome Polymorphisms and Cancer},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {22},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jan},
url = {https://doi.org/10.3390%2Fijms22031094},
number = {3},
pages = {1094},
doi = {10.3390/ijms22031094}
}
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Wilson, Claire, and Aditi Kanhere. “8q24.21 Locus: A Paradigm to Link Non-Coding RNAs, Genome Polymorphisms and Cancer.” International Journal of Molecular Sciences, vol. 22, no. 3, Jan. 2021, p. 1094. https://doi.org/10.3390%2Fijms22031094.