Open Access
International Journal of Molecular Sciences, volume 22, issue 8, pages 3827
Human Mitoribosome Biogenesis and Its Emerging Links to Disease
Lopez Sanchez M Isabel G
1
,
Krüger Annika
2, 3
,
Shiriaev Dmitrii I
2, 3
,
Liu Yong
2, 3
,
Rorbach Joanna
2, 3
1
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne, VIC 3002, Australia
|
Publication type: Journal Article
Publication date: 2021-04-07
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
33917098
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Mammalian mitochondrial ribosomes (mitoribosomes) synthesize a small subset of proteins, which are essential components of the oxidative phosphorylation machinery. Therefore, their function is of fundamental importance to cellular metabolism. The assembly of mitoribosomes is a complex process that progresses through numerous maturation and protein-binding events coordinated by the actions of several assembly factors. Dysregulation of mitoribosome production is increasingly recognized as a contributor to metabolic and neurodegenerative diseases. In recent years, mutations in multiple components of the mitoribosome assembly machinery have been associated with a range of human pathologies, highlighting their importance to cell function and health. Here, we provide a review of our current understanding of mitoribosome biogenesis, highlighting the key factors involved in this process and the growing number of mutations in genes encoding mitoribosomal RNAs, proteins, and assembly factors that lead to human disease.
Citations by journals
1
2
|
|
Nature
|
Nature
2 publications, 6.67%
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
2 publications, 6.67%
|
Nucleic Acids Research
|
Nucleic Acids Research
2 publications, 6.67%
|
Methods in Molecular Biology
|
Methods in Molecular Biology
2 publications, 6.67%
|
Frontiers in Physiology
|
Frontiers in Physiology
2 publications, 6.67%
|
Frontiers in Cell and Developmental Biology
|
Frontiers in Cell and Developmental Biology
1 publication, 3.33%
|
Frontiers in Genetics
|
Frontiers in Genetics
1 publication, 3.33%
|
Scientific Reports
|
Scientific Reports
1 publication, 3.33%
|
Mitochondrion
|
Mitochondrion
1 publication, 3.33%
|
Biochimie
|
Biochimie
1 publication, 3.33%
|
Trends in Biochemical Sciences
|
Trends in Biochemical Sciences
1 publication, 3.33%
|
Journal of Neuroscience Research
|
Journal of Neuroscience Research
1 publication, 3.33%
|
RNA Biology
|
RNA Biology
1 publication, 3.33%
|
American Journal of Physiology - Lung Cellular and Molecular Physiology
|
American Journal of Physiology - Lung Cellular and Molecular Physiology
1 publication, 3.33%
|
Pathology Research and Practice
|
Pathology Research and Practice
1 publication, 3.33%
|
Biology
|
Biology
1 publication, 3.33%
|
Life
|
Life
1 publication, 3.33%
|
Nature Communications
|
Nature Communications
1 publication, 3.33%
|
Acta Naturae
|
Acta Naturae, 1, 3.33%
Acta Naturae
1 publication, 3.33%
|
Cell Discovery
|
Cell Discovery
1 publication, 3.33%
|
Molecular Cell
|
Molecular Cell
1 publication, 3.33%
|
1
2
|
Citations by publishers
1
2
3
4
5
6
7
|
|
Springer Nature
|
Springer Nature
7 publications, 23.33%
|
Elsevier
|
Elsevier
5 publications, 16.67%
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 13.33%
|
Frontiers Media S.A.
|
Frontiers Media S.A.
4 publications, 13.33%
|
Oxford University Press
|
Oxford University Press
2 publications, 6.67%
|
Wiley
|
Wiley
1 publication, 3.33%
|
Taylor & Francis
|
Taylor & Francis
1 publication, 3.33%
|
American Physiological Society
|
American Physiological Society
1 publication, 3.33%
|
Acta Naturae Ltd
|
Acta Naturae Ltd, 1, 3.33%
Acta Naturae Ltd
1 publication, 3.33%
|
1
2
3
4
5
6
7
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2021,2022,2023,2024],"ids":[0,0,0,0],"codes":[0,0,0,0],"imageUrls":["","","",""],"datasets":[{"label":"Citations number","data":[2,10,15,3],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["6.67","33.33","50","10"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Nature","International Journal of Molecular Sciences","Nucleic Acids Research","Methods in Molecular Biology","Frontiers in Physiology","Frontiers in Cell and Developmental Biology","Frontiers in Genetics","Scientific Reports","Mitochondrion","Biochimie","Trends in Biochemical Sciences","Journal of Neuroscience Research","RNA Biology","American Journal of Physiology - Lung Cellular and Molecular Physiology","Pathology Research and Practice","Biology","Life","Nature Communications","Acta Naturae","Cell Discovery","Molecular Cell"],"ids":[14611,14627,23904,3516,15670,12128,13242,13767,18142,4794,4668,21633,7613,21898,2120,24144,23944,3231,7401,22751,19820],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/eZQGZ1aBN8Xm8Yr5YG7nBeNQtWLPrca5SfDreLbq_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[2,2,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[6.67,6.67,6.67,6.67,6.67,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Springer Nature","Elsevier","Multidisciplinary Digital Publishing Institute (MDPI)","Frontiers Media S.A.","Oxford University Press","Wiley","Taylor & Francis","American Physiological Society","Acta Naturae Ltd"],"ids":[8,17,202,208,19,11,18,166,7905],"codes":[0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/eZQGZ1aBN8Xm8Yr5YG7nBeNQtWLPrca5SfDreLbq_medium.webp",""],"datasets":[{"label":"","data":[7,5,4,4,2,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[23.33,16.67,13.33,13.33,6.67,3.33,3.33,3.33,3.33],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Lopez Sanchez M. I. G. et al. Human Mitoribosome Biogenesis and Its Emerging Links to Disease // International Journal of Molecular Sciences. 2021. Vol. 22. No. 8. p. 3827.
GOST all authors (up to 50)
Copy
Lopez Sanchez M. I. G., Krüger A., Shiriaev D. I., Liu Y., Rorbach J. Human Mitoribosome Biogenesis and Its Emerging Links to Disease // International Journal of Molecular Sciences. 2021. Vol. 22. No. 8. p. 3827.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/ijms22083827
UR - https://doi.org/10.3390%2Fijms22083827
TI - Human Mitoribosome Biogenesis and Its Emerging Links to Disease
T2 - International Journal of Molecular Sciences
AU - Shiriaev, Dmitrii I
AU - Rorbach, Joanna
AU - Lopez Sanchez, M Isabel G
AU - Krüger, Annika
AU - Liu, Yong
PY - 2021
DA - 2021/04/07 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 3827
IS - 8
VL - 22
PMID - 33917098
SN - 1661-6596
SN - 1422-0067
ER -
Cite this
BibTex
Copy
@article{2021_Lopez Sanchez,
author = {Dmitrii I Shiriaev and Joanna Rorbach and M Isabel G Lopez Sanchez and Annika Krüger and Yong Liu},
title = {Human Mitoribosome Biogenesis and Its Emerging Links to Disease},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {22},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {apr},
url = {https://doi.org/10.3390%2Fijms22083827},
number = {8},
pages = {3827},
doi = {10.3390/ijms22083827}
}
Cite this
MLA
Copy
Lopez Sanchez, M. Isabel G., et al. “Human Mitoribosome Biogenesis and Its Emerging Links to Disease.” International Journal of Molecular Sciences, vol. 22, no. 8, Apr. 2021, p. 3827. https://doi.org/10.3390%2Fijms22083827.