Open Access
International Journal of Molecular Sciences, volume 22, issue 16, pages 8635
Conservative and Atypical Ferritins of Sponges
Адамейко К. И.
1
,
Burakov Anton V
2
,
Финошин А. Д.
1
,
Mikhailov Kirill V.
2, 3
,
Кравчук О. И.
1
,
Козлова О. С.
4
,
Gornostaev Nicolay G
1
,
Cherkasov Alexander V
5
,
Erokhov Pavel A.
1
,
Indeykina Maria I
6
,
Bugrova Anna E
6
,
Kononikhin A. S.
7
,
Moiseenko Andrey V.
8
,
Sokolova Olga S.
8
,
Bonchuk Artem N
9
,
Zhegalova Irina V
3, 5, 10
,
Georgiev Anton A
8
,
Mikhailov Victor S.
1
,
Gogoleva Natalia E
4
,
Gazizova Guzel R
4
,
Gusev Oleg A
4, 11, 12
,
1
6
11
RIKEN Center for Integrative Medical Sciences, RIKEN, Yokohama 351-0198, Japan
|
12
Department of Regulatory Transcriptomics for Medical Genetic Diagnostics, Graduate School of Medical Sciences, Juntendo University, Tokyo 113-8421, Japan
|
Publication type: Journal Article
Publication date: 2021-08-11
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
34445356
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Ferritins comprise a conservative family of proteins found in all species and play an essential role in resistance to redox stress, immune response, and cell differentiation. Sponges (Porifera) are the oldest Metazoa that show unique plasticity and regenerative potential. Here, we characterize the ferritins of two cold-water sponges using proteomics, spectral microscopy, and bioinformatic analysis. The recently duplicated conservative HdF1a/b and atypical HdF2 genes were found in the Halisarca dujardini genome. Multiple related transcripts of HpF1 were identified in the Halichondria panicea transcriptome. Expression of HdF1a/b was much higher than that of HdF2 in all annual seasons and regulated differently during the sponge dissociation/reaggregation. The presence of the MRE and HRE motifs in the HdF1 and HdF2 promotor regions and the IRE motif in mRNAs of HdF1 and HpF indicates that sponge ferritins expression depends on the cellular iron and oxygen levels. The gel electrophoresis combined with specific staining and mass spectrometry confirmed the presence of ferric ions and ferritins in multi-subunit complexes. The 3D modeling predicts the iron-binding capacity of HdF1 and HpF1 at the ferroxidase center and the absence of iron-binding in atypical HdF2. Interestingly, atypical ferritins lacking iron-binding capacity were found in genomes of many invertebrate species. Their function deserves further research.
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1
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Citations by publishers
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1
2
3
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 42.86%
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Springer Nature
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1 publication, 14.29%
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Taylor & Francis
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Taylor & Francis
1 publication, 14.29%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 14.29%
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1
2
3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Адамейко К. И. et al. Conservative and Atypical Ferritins of Sponges // International Journal of Molecular Sciences. 2021. Vol. 22. No. 16. p. 8635.
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Адамейко К. И., Burakov A. V., Финошин А. Д., Mikhailov K. V., Кравчук О. И., Козлова О. С., Gornostaev N. G., Cherkasov A. V., Erokhov P. A., Indeykina M. I., Bugrova A. E., Kononikhin A. S., Moiseenko A. V., Sokolova O. S., Bonchuk A. N., Zhegalova I. V., Georgiev A. A., Mikhailov V. S., Gogoleva N. E., Gazizova G. R., Шагимарданова Е. И., Gusev O. A., Люпина Ю. В. Conservative and Atypical Ferritins of Sponges // International Journal of Molecular Sciences. 2021. Vol. 22. No. 16. p. 8635.
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TY - JOUR
DO - 10.3390/ijms22168635
UR - https://doi.org/10.3390%2Fijms22168635
TI - Conservative and Atypical Ferritins of Sponges
T2 - International Journal of Molecular Sciences
AU - Burakov, Anton V
AU - Mikhailov, Kirill V.
AU - Gornostaev, Nicolay G
AU - Cherkasov, Alexander V
AU - Erokhov, Pavel A.
AU - Indeykina, Maria I
AU - Bugrova, Anna E
AU - Moiseenko, Andrey V.
AU - Bonchuk, Artem N
AU - Zhegalova, Irina V
AU - Georgiev, Anton A
AU - Mikhailov, Victor S.
AU - Gogoleva, Natalia E
AU - Gazizova, Guzel R
AU - Gusev, Oleg A
AU - Адамейко, К. И.
AU - Финошин, А. Д.
AU - Кравчук, О. И.
AU - Козлова, О. С.
AU - Kononikhin, A. S.
AU - Sokolova, Olga S.
AU - Шагимарданова, Е. И.
AU - Люпина, Ю. В.
PY - 2021
DA - 2021/08/11 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 8635
IS - 16
VL - 22
PMID - 34445356
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2021_Адамейко,
author = {Anton V Burakov and Kirill V. Mikhailov and Nicolay G Gornostaev and Alexander V Cherkasov and Pavel A. Erokhov and Maria I Indeykina and Anna E Bugrova and Andrey V. Moiseenko and Artem N Bonchuk and Irina V Zhegalova and Anton A Georgiev and Victor S. Mikhailov and Natalia E Gogoleva and Guzel R Gazizova and Oleg A Gusev and К. И. Адамейко and А. Д. Финошин and О. И. Кравчук and О. С. Козлова and A. S. Kononikhin and Olga S. Sokolova and Е. И. Шагимарданова and Ю. В. Люпина},
title = {Conservative and Atypical Ferritins of Sponges},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {22},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {aug},
url = {https://doi.org/10.3390%2Fijms22168635},
number = {16},
pages = {8635},
doi = {10.3390/ijms22168635}
}
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Адамейко, К. И., et al. “Conservative and Atypical Ferritins of Sponges.” International Journal of Molecular Sciences, vol. 22, no. 16, Aug. 2021, p. 8635. https://doi.org/10.3390%2Fijms22168635.