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International Journal of Molecular Sciences, volume 23, issue 22, pages 14224

Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing

Gisina Alisa ¹

Kholodenko Irina ¹

Kim Yan S ¹

Abakumov Maxim A. ²

Lupatov Alexey ¹

Yarygin Konstantin N ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Laboratory of Cell Biology, V.N. Orekhovich Institute of Biomedical Chemistry, 119121 Moscow, Russia |

Drug Delivery Systems Laboratory, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia |

Publication type: Journal Article

Publication date: 2022-11-17

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: International Journal of Molecular Sciences

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Quartile WOS

Impact factor: 5.6

ISSN: 16616596, 14220067

DOI: 10.3390/ijms232214224

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Catalysis

Organic Chemistry

Inorganic Chemistry

Physical and Theoretical Chemistry

Computer Science Applications

Spectroscopy

Molecular Biology

General Medicine

Abstract

Glioma is the most common type of primary CNS tumor, composed of cells that resemble normal glial cells. Recent genetic studies have provided insight into the inter-tumoral heterogeneity of gliomas, resulting in the updated 2021 WHO classification of gliomas. Thorough understanding of inter-tumoral heterogeneity has already improved the prognosis and treatment outcomes of some types of gliomas. Currently, the challenge for researchers is to study the intratumoral cell heterogeneity of newly defined glioma subtypes. Cancer stem cells (CSCs) present in gliomas and many other tumors are an example of intratumoral heterogeneity of great importance. In this review, we discuss the modern concept of glioma stem cells and recent single-cell sequencing-driven progress in the research of intratumoral glioma cell heterogeneity. The particular emphasis was placed on the recently revealed variations of the cell composition of the subtypes of the adult-type diffuse gliomas, including astrocytoma, oligodendroglioma and glioblastoma. The novel data explain the inconsistencies in earlier glioma stem cell research and also provide insight into the development of more effective targeted therapy and the cell-based immunotherapy of gliomas. Separate sections are devoted to the description of single-cell sequencing approach and its role in the development of cell-based immunotherapies for glioma.

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Citations by journals

	1 2
Biomedicines	Biomedicines, 2, 20% Biomedicines 2 publications, 20%
Cells	Cells, 1, 10% Cells 1 publication, 10%
Cellular and Molecular Life Sciences	Cellular and Molecular Life Sciences, 1, 10% Cellular and Molecular Life Sciences 1 publication, 10%
PLoS ONE	PLoS ONE, 1, 10% PLoS ONE 1 publication, 10%
Functional and Integrative Genomics	Functional and Integrative Genomics, 1, 10% Functional and Integrative Genomics 1 publication, 10%
Molecular and Cellular Biochemistry	Molecular and Cellular Biochemistry, 1, 10% Molecular and Cellular Biochemistry 1 publication, 10%
Cancers	Cancers, 1, 10% Cancers 1 publication, 10%
Journal of Fluorescence	Journal of Fluorescence, 1, 10% Journal of Fluorescence 1 publication, 10%
Pharmaceuticals	Pharmaceuticals, 1, 10% Pharmaceuticals 1 publication, 10%
	1 2

Citations by publishers

	1 2 3 4 5
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 5, 50% Multidisciplinary Digital Publishing Institute (MDPI) 5 publications, 50%
Springer Nature	Springer Nature, 4, 40% Springer Nature 4 publications, 40%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 10% Public Library of Science (PLoS) 1 publication, 10%
	1 2 3 4 5

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Gisina A. et al. Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing // International Journal of Molecular Sciences. 2022. Vol. 23. No. 22. p. 14224.

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Gisina A., Kholodenko I., Kim Y. S., Abakumov M. A., Lupatov A., Yarygin K. N. Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing // International Journal of Molecular Sciences. 2022. Vol. 23. No. 22. p. 14224.

RIS |

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RIS Copy

TY - JOUR

DO - 10.3390/ijms232214224

UR - https://doi.org/10.3390%2Fijms232214224

TI - Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing

T2 - International Journal of Molecular Sciences

AU - Gisina, Alisa

AU - Kholodenko, Irina

AU - Kim, Yan S

AU - Abakumov, Maxim A.

AU - Lupatov, Alexey

AU - Yarygin, Konstantin N

PY - 2022

DA - 2022/11/17 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 14224

IS - 22

VL - 23

SN - 1661-6596

SN - 1422-0067

ER -

BibTex |

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BibTex Copy

@article{2022_Gisina,

author = {Alisa Gisina and Irina Kholodenko and Yan S Kim and Maxim A. Abakumov and Alexey Lupatov and Konstantin N Yarygin},

title = {Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing},

journal = {International Journal of Molecular Sciences},

year = {2022},

volume = {23},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {nov},

url = {https://doi.org/10.3390%2Fijms232214224},

number = {22},

pages = {14224},

doi = {10.3390/ijms232214224}

}

MLA

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MLA Copy

Gisina, Alisa, et al. “Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing.” International Journal of Molecular Sciences, vol. 23, no. 22, Nov. 2022, p. 14224. https://doi.org/10.3390%2Fijms232214224.

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Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

International Journal of Molecular Sciences

Quartile SCImago

Quartile WOS

Impact factor

5.6

ISSN

16616596 (Print)
14220067 (Electronic)

Labs

Biomedical Nanomaterials Laboratory

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