Open Access
Open access
Marine Drugs, volume 18, issue 6, pages 311

Bioactive Molecular Networking for Mapping the Antimicrobial Constituents of the Baltic Brown Alga Fucus vesiculosus

Astone Francesca Anna 1
1
 
GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Products Chemistry, GEOMAR Helmholtz Centre for Ocean Research Kiel, Am Kiel-Kanal 44, 24106 Kiel, Germany
2
 
Faculty of Mathematics and Natural Sciences, Kiel University, Christian-Albrechts-Platz 4, 424118 Kiel, Germany
Publication typeJournal Article
Publication date2020-06-13
Journal: Marine Drugs
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor5.4
ISSN16603397
PubMed ID:  32545808
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract

The brown alga Fucus vesiculosus is common to the intertidal zones of the Baltic Sea, where it is exposed to high fouling pressures by microorganisms. Our previous studies showed, repeatedly, the consistent antimicrobial activity of F. vesiculosus crude extracts against human pathogens, while untargeted metabolomics analyses have revealed a variety of metabolites. In this study, we applied the UPLC-QToF-MS/MS-based “bioactive molecular networking” (BMN) concept on the most bioactive n-hexane and n-butanol subextracts of Baltic F. vesiculosus coupled with in silico dereplication tools to identify the compounds responsible for antimicrobial activity. The first antimicrobial cluster identified by BMN was galactolipids. Our targeted isolation efforts for this class led to the isolation of six monogalactosyldiacylglycerol (MGDG) derivatives (1–6) and one digalactosyldiacylglycerol (DGDG, 7). The MGDGs 5 and 6 and the DGDG 7 exhibited activity against Staphylococcus aureus. The second compound class with high bioactivity was phlorotannins. In particular, phlorethol-type phlorotannins showed high correlations with antimicrobial activity based on the BMN approach, and two phlorotannins (8–9) were isolated. This study shows that antimicrobial components of F. vesiculosus reside in the algal cell walls and membranes and that BMN provides a complementary tool for the targeted isolation of bioactive metabolites.

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GOST |
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GOST Copy
Buedenbender L. et al. Bioactive Molecular Networking for Mapping the Antimicrobial Constituents of the Baltic Brown Alga Fucus vesiculosus // Marine Drugs. 2020. Vol. 18. No. 6. p. 311.
GOST all authors (up to 50) Copy
Buedenbender L., Astone F. A., TASDEMIR D. Bioactive Molecular Networking for Mapping the Antimicrobial Constituents of the Baltic Brown Alga Fucus vesiculosus // Marine Drugs. 2020. Vol. 18. No. 6. p. 311.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3390/md18060311
UR - https://doi.org/10.3390%2Fmd18060311
TI - Bioactive Molecular Networking for Mapping the Antimicrobial Constituents of the Baltic Brown Alga Fucus vesiculosus
T2 - Marine Drugs
AU - Astone, Francesca Anna
AU - Buedenbender, Larissa
AU - TASDEMIR, D.
PY - 2020
DA - 2020/06/13 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 311
IS - 6
VL - 18
PMID - 32545808
SN - 1660-3397
ER -
BibTex |
Cite this
BibTex Copy
@article{2020_Buedenbender
author = {Francesca Anna Astone and Larissa Buedenbender and D. TASDEMIR},
title = {Bioactive Molecular Networking for Mapping the Antimicrobial Constituents of the Baltic Brown Alga Fucus vesiculosus},
journal = {Marine Drugs},
year = {2020},
volume = {18},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jun},
url = {https://doi.org/10.3390%2Fmd18060311},
number = {6},
pages = {311},
doi = {10.3390/md18060311}
}
MLA
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MLA Copy
Buedenbender, Larissa, et al. “Bioactive Molecular Networking for Mapping the Antimicrobial Constituents of the Baltic Brown Alga Fucus vesiculosus.” Marine Drugs, vol. 18, no. 6, Jun. 2020, p. 311. https://doi.org/10.3390%2Fmd18060311.
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