Open Access
Molecules, volume 24, issue 5, pages 892
The Concept of an Ideal Antibiotic: Implications for Drug Design
1
Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary
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Publication type: Journal Article
Publication date: 2019-03-03
PubMed ID:
30832456
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
The emergence and spread of antibiotic-resistant pathogens is a major public health issue, which requires global action of an intersectoral nature. Multidrug-resistant (MDR) pathogens—especially “ESKAPE” bacteria—can withstand lethal doses of antibiotics with various chemical structures and mechanisms of action. Pharmaceutical companies are increasingly turning away from participating in the development of new antibiotics, due to the regulatory environment and the financial risks. There is an urgent need for innovation in antibiotic research, as classical discovery platforms (e.g., mining soil Streptomycetes) are no longer viable options. In addition to discovery platforms, a concept of an ideal antibiotic should be postulated, to act as a blueprint for future drugs, and to aid researchers, pharmaceutical companies, and relevant stakeholders in selecting lead compounds. Based on 150 references, the aim of this review is to summarize current advances regarding the challenges of antibiotic drug discovery and the specific attributes of an ideal antibacterial drug (a prodrug or generally reactive compound with no specific target, broad-spectrum antibacterial activity, adequate penetration through the Gram-negative cell wall, activity in biofilms and in hard-to-treat infections, accumulation in macrophages, availability for oral administration, and for use in sensitive patient groups).
Citations by journals
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Citations by publishers
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70
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Multidisciplinary Digital Publishing Institute (MDPI)
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62 publications, 33.16%
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Hindawi Limited
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American Society for Microbiology
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Wiley
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Bentham Science
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2 publications, 1.07%
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Mary Ann Liebert
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2 publications, 1.07%
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2 publications, 1.07%
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1 publication, 0.53%
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Slovenian Medical Society, 1, 0.53%
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Oriental Scientific Publishing Company
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Oriental Scientific Publishing Company, 1, 0.53%
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1 publication, 0.53%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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MLA
Cite this
RIS
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TY - JOUR
DO - 10.3390/molecules24050892
UR - https://doi.org/10.3390%2Fmolecules24050892
TI - The Concept of an Ideal Antibiotic: Implications for Drug Design
T2 - Molecules
AU - Gajdács, Márió
PY - 2019
DA - 2019/03/03 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 892
IS - 5
VL - 24
PMID - 30832456
SN - 1420-3049
ER -
Cite this
BibTex
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@article{2019_Gajdács,
author = {Márió Gajdács},
title = {The Concept of an Ideal Antibiotic: Implications for Drug Design},
journal = {Molecules},
year = {2019},
volume = {24},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {mar},
url = {https://doi.org/10.3390%2Fmolecules24050892},
number = {5},
pages = {892},
doi = {10.3390/molecules24050892}
}
Cite this
MLA
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Gajdács, Márió. “The Concept of an Ideal Antibiotic: Implications for Drug Design.” Molecules, vol. 24, no. 5, Mar. 2019, p. 892. https://doi.org/10.3390%2Fmolecules24050892.