Open Access
Molecules, volume 25, issue 11, pages 2636
Molecular Network-Guided Alkaloid Profiling of Aerial Parts of Papaver nudicaule L. Using LC-HRMS
1
Korean Medicine Clinical Trial Center (K-CTC), Kyung Hee University Korean Medicine Hospital, Seoul 02454, Korea
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2
Gene Engineering Division, National Institute of Agricultural Sciences, Rural Development Administration, Jeonju-si, Jeollabuk-do 54874, Korea
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3
Department of Science in Korean Medicine, KHU-KIST Department of Converging Science & Technology, and Bionanocomposite Research Center, Kyung Hee University, Seoul 02447, Korea
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4
Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea
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Publication type: Journal Article
Publication date: 2020-06-05
PubMed ID:
32517053
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Papaver nudicaule L. (Iceland poppy) is widely used for ornamental purposes. A previous study demonstrated the alleviation of lipopolysaccharide-induced inflammation mediated by P. nudicaule extract through nuclear factor-kappa B and signal transducer and activator of transcription 3 inactivation. As isoquinoline alkaloids are chemical markers and bioactive constituents of Papaver species, the present study investigated the alkaloid profile of aerial parts of five P. nudicaule cultivars with different flower colors and a P. rhoeas cropped for two years. A combination of liquid chromatography high-resolution mass spectrometry and molecular networking was used to cluster isoquinoline alkaloids in the species and highlight the possible metabolites. Aside from the 12 compounds, including rotundine, muramine, and allocryptopine, identified from Global Natural Products Social library and reported information, 46 structurally related metabolites were quantitatively investigated. Forty-two and 16 compounds were proposed for chemical profiles of P. nudicaule and P. rhoeas, respectively. Some species-specific metabolites showed similar fragmentation patterns. The alkaloid abundance of P. nudicaule differed depending on the flower color, and the possible chemical markers were proposed. These results show that molecular networking-guided dereplication allows investigation of unidentified metabolites. The derived chemical profile may facilitate evaluation of P. nudicaule quality for pharmacological applications.
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Citations by publishers
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1 publication, 10%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Song K. et al. Molecular Network-Guided Alkaloid Profiling of Aerial Parts of Papaver nudicaule L. Using LC-HRMS // Molecules. 2020. Vol. 25. No. 11. p. 2636.
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Song K., Lee S., Lee M., Lee S. G., Ha I. J. Molecular Network-Guided Alkaloid Profiling of Aerial Parts of Papaver nudicaule L. Using LC-HRMS // Molecules. 2020. Vol. 25. No. 11. p. 2636.
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TY - JOUR
DO - 10.3390/molecules25112636
UR - https://doi.org/10.3390%2Fmolecules25112636
TI - Molecular Network-Guided Alkaloid Profiling of Aerial Parts of Papaver nudicaule L. Using LC-HRMS
T2 - Molecules
AU - Song, Kwangho
AU - Lee, Min-Young
AU - Lee, Sang-Choon
AU - Lee, Seok Geun
AU - Ha, In Jin
PY - 2020
DA - 2020/06/05 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 2636
IS - 11
VL - 25
PMID - 32517053
SN - 1420-3049
ER -
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@article{2020_Song,
author = {Kwangho Song and Min-Young Lee and Sang-Choon Lee and Seok Geun Lee and In Jin Ha},
title = {Molecular Network-Guided Alkaloid Profiling of Aerial Parts of Papaver nudicaule L. Using LC-HRMS},
journal = {Molecules},
year = {2020},
volume = {25},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jun},
url = {https://doi.org/10.3390%2Fmolecules25112636},
number = {11},
pages = {2636},
doi = {10.3390/molecules25112636}
}
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Song, Kwangho, et al. “Molecular Network-Guided Alkaloid Profiling of Aerial Parts of Papaver nudicaule L. Using LC-HRMS.” Molecules, vol. 25, no. 11, Jun. 2020, p. 2636. https://doi.org/10.3390%2Fmolecules25112636.