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Open access
Molecules, volume 25, issue 20, pages 4799

Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing

Publication typeJournal Article
Publication date2020-10-19
Journal: Molecules
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor4.6
ISSN14203049
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Triterpenes from the outer bark of birch (TE) are known for various pharmacological effects including enhanced wound healing. Apart from an already authorized oleogel, electrospun nanofiber mats containing these triterpenes in a polyvinyl alcohol (PVA) matrix appear to be an advantageous application form. The effects of PVA molecular weight and concentration on the fiber morphology have been investigated. Three different molecular weights of PVA ranging from 67 to 186 kDa were used. The concentration of PVA was varied from 5 to 20 wt%. Polymer solutions were blended with colloidal dispersions of birch bark extract at a weight ratio of 60:40 (wt.%). The estimated viscosity of polymer solutions was directly linked to their concentration and molecular weight. In addition, both pure and blended solutions showed viscoelastic properties with a dominant viscous response in the bulk. Fiber morphology was confirmed using scanning electron microscopy (SEM). Both polymer concentration and molecular weight were found to be significant factors affecting the diameter of the fibers. Fiber diameter increased with a higher molecular weight and polymer concentration as more uniform fibers were obtained using PVA of higher molecular weight (146–186 kDa). In vitro drug release and ex vivo permeation studies indicated a faster drug release of betulin from electrospun scaffolds with lower PVA molecular weight. Our research suggests that the fabricated TE-loaded PVA electrospun dressings represent potential delivery systems of TE for wound care applications.

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GOST Copy
Mwiiri F. K., Daniels R. Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing // Molecules. 2020. Vol. 25. No. 20. p. 4799.
GOST all authors (up to 50) Copy
Mwiiri F. K., Daniels R. Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing // Molecules. 2020. Vol. 25. No. 20. p. 4799.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/molecules25204799
UR - https://doi.org/10.3390%2Fmolecules25204799
TI - Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing
T2 - Molecules
AU - Mwiiri, Francis Kamau
AU - Daniels, Rolf
PY - 2020
DA - 2020/10/19 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 4799
IS - 20
VL - 25
PMID - 33086645
SN - 1420-3049
ER -
BibTex |
Cite this
BibTex Copy
@article{2020_Mwiiri
author = {Francis Kamau Mwiiri and Rolf Daniels},
title = {Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing},
journal = {Molecules},
year = {2020},
volume = {25},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {oct},
url = {https://doi.org/10.3390%2Fmolecules25204799},
number = {20},
pages = {4799},
doi = {10.3390/molecules25204799}
}
MLA
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MLA Copy
Mwiiri, Francis Kamau, and Rolf Daniels. “Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing.” Molecules, vol. 25, no. 20, Oct. 2020, p. 4799. https://doi.org/10.3390%2Fmolecules25204799.
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