Open Access
Molecules, volume 27, issue 19, pages 6218
Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity
Nichugovskiy A I
1
,
Trapeznikova Ekaterina
3
,
Ivanov I.
1
,
Kirsanov Kirill I.
2, 4
,
Tron Gian Cesare
6
,
2
3
Publication type: Journal Article
Publication date: 2022-09-21
PubMed ID:
36234753
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Natural polyamines (PAs) are involved in the processes of proliferation and differentiation of cancer cells. Lipophilic synthetic polyamines (LPAs) induce the cell death of various cancer cell lines. In the current paper, we have demonstrated a new method for synthesis of LPAs via the multicomponent Ugi reaction and subsequent reduction of amide groups by PhSiH3. The anticancer activity of the obtained compounds was evaluated in the A-549, MCF7, and HCT116 cancer cell lines. For the first time, it was shown that the anticancer activity of LPAs with piperazine fragments is comparable with that of aliphatic LPAs. The presence of a diglyceride fragment in the structure of LPAs appears to be a key factor for the manifestation of high anticancer activity. The findings of the study strongly support further research in the field of LPAs and their derivatives.
Citations by journals
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1
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Biomedicines
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Biomedicines
1 publication, 33.33%
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Mendeleev Communications
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Mendeleev Communications
1 publication, 33.33%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 33.33%
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1
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Citations by publishers
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1
2
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 66.67%
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Elsevier
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Elsevier
1 publication, 33.33%
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1
2
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Nichugovskiy A. I. et al. Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity // Molecules. 2022. Vol. 27. No. 19. p. 6218.
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Nichugovskiy A. I., Maksimova V., Trapeznikova E., Eshtukova Shcheglova E. A., Ivanov I., Yakubovskaya M. G., Kirsanov K. I., Cheshkov D. A., Tron G. C., Maslov M. Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity // Molecules. 2022. Vol. 27. No. 19. p. 6218.
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TY - JOUR
DO - 10.3390/molecules27196218
UR - https://doi.org/10.3390%2Fmolecules27196218
TI - Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity
T2 - Molecules
AU - Maksimova, Varvara
AU - Trapeznikova, Ekaterina
AU - Nichugovskiy, A I
AU - Eshtukova Shcheglova, E A
AU - Ivanov, I.
AU - Yakubovskaya, Marianna G.
AU - Kirsanov, Kirill I.
AU - Cheshkov, Dmitry A.
AU - Tron, Gian Cesare
AU - Maslov, Michael
PY - 2022
DA - 2022/09/21 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 6218
IS - 19
VL - 27
PMID - 36234753
SN - 1420-3049
ER -
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@article{2022_Nichugovskiy,
author = {Varvara Maksimova and Ekaterina Trapeznikova and A I Nichugovskiy and E A Eshtukova Shcheglova and I. Ivanov and Marianna G. Yakubovskaya and Kirill I. Kirsanov and Dmitry A. Cheshkov and Gian Cesare Tron and Michael Maslov},
title = {Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity},
journal = {Molecules},
year = {2022},
volume = {27},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {sep},
url = {https://doi.org/10.3390%2Fmolecules27196218},
number = {19},
pages = {6218},
doi = {10.3390/molecules27196218}
}
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MLA
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Nichugovskiy, A. I., et al. “Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity.” Molecules, vol. 27, no. 19, Sep. 2022, p. 6218. https://doi.org/10.3390%2Fmolecules27196218.