Open Access
Pharmaceutics, volume 13, issue 8, pages 1258
Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Simultaneous Use in Magnetic Resonance and Fluorescent Imaging of Brain Tumors
Arias-Ramos Nuria
1
,
Ibarra Luis Exequiel
2, 3
,
Serrano Torres María
1
,
Yagüe Balbino
1
,
Caverzán Matías Daniel
3, 4
,
Chesta Carlos Alberto
4, 5
,
Palacios Rodrigo Emiliano
4, 5
,
López-Larrubia Pilar
1
1
Instituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), 28029 Madrid, Spain
|
2
Instituto de Biotecnología Ambiental y Salud (INBIAS), Universidad Nacional de Río Cuarto (UNRC) y CONICET, Córdoba X5800BIA, Argentina
|
3
Departamento de Biología Molecular, Facultad de Ciencias Exactas, Fisicoquímicas y Naturales, Universidad Nacional de Río Cuarto (UNRC), Córdoba X5800BIA, Argentina
|
4
Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados (IITEMA), Universidad Nacional de Río Cuarto y CONICET, Córdoba X5800BIA, Argentina
|
5
Departamento de Química, Facultad de Ciencias Exactas, Fisicoquímicas y Naturales, UNRC, Córdoba X5800BIA, Argentina
|
Publication type: Journal Article
Publication date: 2021-08-14
PubMed ID:
34452219
Pharmaceutical Science
Abstract
Conjugated polymer nanoparticles (CPNs) have emerged as advanced polymeric nanoplatforms in biomedical applications by virtue of extraordinary properties including high fluorescence brightness, large absorption coefficients of one and two-photons, and excellent photostability and colloidal stability in water and physiological medium. In addition, low cytotoxicity, easy functionalization, and the ability to modify CPN photochemical properties by the incorporation of dopants, convert them into excellent theranostic agents with multifunctionality for imaging and treatment. In this work, CPNs were designed and synthesized by incorporating a metal oxide magnetic core (Fe3O4 and NiFe2O4 nanoparticles, 5 nm) into their matrix during the nanoprecipitation method. This modification allowed the in vivo monitoring of nanoparticles in animal models using magnetic resonance imaging (MRI) and intravital fluorescence, techniques widely used for intracranial tumors evaluation. The modified CPNs were assessed in vivo in glioblastoma (GBM) bearing mice, both heterotopic and orthotopic developed models. Biodistribution studies were performed with MRI acquisitions and fluorescence images up to 24 h after the i.v. nanoparticles administration. The resulting IONP-doped CPNs were biocompatible in GBM tumor cells in vitro with an excellent cell incorporation depending on nanoparticle concentration exposure. IONP-doped CPNs were detected in tumor and excretory organs of the heterotopic GBM model after i.v. and i.t. injection. However, in the orthotopic GBM model, the size of the nanoparticles is probably hindering a higher effect on intratumorally T2-weighted images (T2WI) signals and T2 values. The photodynamic therapy (PDT)—cytotoxicity of CPNs was not either affected by the IONPs incorporation into the nanoparticles.
Citations by journals
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1 publication, 4.76%
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1 publication, 4.76%
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1 publication, 4.76%
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1 publication, 4.76%
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1 publication, 4.76%
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1
2
3
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6
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Citations by publishers
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2
4
6
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10
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Multidisciplinary Digital Publishing Institute (MDPI)
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10 publications, 47.62%
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Springer Nature
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Springer Nature
4 publications, 19.05%
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Future Medicine
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1 publication, 4.76%
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Elsevier
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Elsevier
1 publication, 4.76%
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Dove Medical Press
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Dove Medical Press
1 publication, 4.76%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
1 publication, 4.76%
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2
4
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10
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Arias-Ramos N. et al. Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Simultaneous Use in Magnetic Resonance and Fluorescent Imaging of Brain Tumors // Pharmaceutics. 2021. Vol. 13. No. 8. p. 1258.
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Arias-Ramos N., Ibarra L. E., Serrano Torres M., Yagüe B., Caverzán M. D., Chesta C. A., Palacios R. E., López-Larrubia P. Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Simultaneous Use in Magnetic Resonance and Fluorescent Imaging of Brain Tumors // Pharmaceutics. 2021. Vol. 13. No. 8. p. 1258.
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TY - JOUR
DO - 10.3390/pharmaceutics13081258
UR - https://doi.org/10.3390%2Fpharmaceutics13081258
TI - Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Simultaneous Use in Magnetic Resonance and Fluorescent Imaging of Brain Tumors
T2 - Pharmaceutics
AU - Serrano Torres, María
AU - Yagüe, Balbino
AU - Chesta, Carlos Alberto
AU - Palacios, Rodrigo Emiliano
AU - Arias-Ramos, Nuria
AU - Ibarra, Luis Exequiel
AU - Caverzán, Matías Daniel
AU - López-Larrubia, Pilar
PY - 2021
DA - 2021/08/14 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1258
IS - 8
VL - 13
PMID - 34452219
SN - 1999-4923
ER -
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@article{2021_Arias-Ramos,
author = {María Serrano Torres and Balbino Yagüe and Carlos Alberto Chesta and Rodrigo Emiliano Palacios and Nuria Arias-Ramos and Luis Exequiel Ibarra and Matías Daniel Caverzán and Pilar López-Larrubia},
title = {Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Simultaneous Use in Magnetic Resonance and Fluorescent Imaging of Brain Tumors},
journal = {Pharmaceutics},
year = {2021},
volume = {13},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {aug},
url = {https://doi.org/10.3390%2Fpharmaceutics13081258},
number = {8},
pages = {1258},
doi = {10.3390/pharmaceutics13081258}
}
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Arias-Ramos, Nuria, et al. “Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Simultaneous Use in Magnetic Resonance and Fluorescent Imaging of Brain Tumors.” Pharmaceutics, vol. 13, no. 8, Aug. 2021, p. 1258. https://doi.org/10.3390%2Fpharmaceutics13081258.