Open Access
Pharmaceutics, volume 13, issue 9, pages 1512
Graphene Oxide and Graphene Quantum Dots as Delivery Systems of Cationic Porphyrins: Photo-Antiproliferative Activity Evaluation towards T24 Human Bladder Cancer Cells
Menilli Luca
1, 2
,
Monteiro Ana R
3, 4
,
Lazzarotto Silvia
1
,
Morais Filipe M P
4
,
Gomes Ana T P C
5, 6
,
Moura N.
4
,
Fateixa Sara
3
,
Faustino Maria AF
4
,
Neves M. C. D.
4
,
Trindade Tito
3
,
Miolo Giorgia
1
1
3
CICECO—Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
|
4
LAQV—Requimte, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
|
5
CESAM, Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal
|
6
Center for Interdisciplinary Investigation (CIIS), Faculty of Dental Medicine, Universidade Católica Portuguesa, 3504-505 Viseu, Portugal
|
Publication type: Journal Article
Publication date: 2021-09-18
PubMed ID:
34575587
Pharmaceutical Science
Abstract
The development of new photodynamic therapy (PDT) agents designed for bladder cancer (BC) treatments is of utmost importance to prevent its recurrence and progression towards more invasive forms. Here, three different porphyrinic photosensitizers (PS) (TMPyP, Zn-TMPyP, and P1-C5) were non-covalently loaded onto graphene oxide (GO) or graphene quantum dots (GQDs) in a one-step process. The cytotoxic effects of the free PS and of the corresponding hybrids were compared upon blue (BL) and red-light (RL) exposure on T24 human BC cells. In addition, intracellular reactive oxygen species (ROS) and singlet oxygen generation were measured. TMPyP and Zn-TMPyP showed higher efficiency under BL (IC50: 0.42 and 0.22 μm, respectively), while P1-C5 was more active under RL (IC50: 0.14 μm). In general, these PS could induce apoptotic cell death through lysosomes damage. The in vitro photosensitizing activity of the PS was not compromised after their immobilization onto graphene-based nanomaterials, with Zn-TMPyP@GQDs being the most promising hybrid system under RL (IC50: 0.37 μg/mL). Overall, our data confirm that GO and GQDs may represent valid platforms for PS delivery, without altering their performance for PDT on BC cells.
Citations by journals
|
1
|
|
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
1 publication, 5.26%
|
|
Journal of Porphyrins and Phthalocyanines
|
Journal of Porphyrins and Phthalocyanines
1 publication, 5.26%
|
|
Antioxidants
|
Antioxidants
1 publication, 5.26%
|
|
Biosensors
|
Biosensors
1 publication, 5.26%
|
|
Frontiers in Materials
|
Frontiers in Materials
1 publication, 5.26%
|
|
Photodiagnosis and Photodynamic Therapy
|
Photodiagnosis and Photodynamic Therapy
1 publication, 5.26%
|
|
Vibrational Spectroscopy
|
Vibrational Spectroscopy
1 publication, 5.26%
|
|
Luminescence
|
Luminescence
1 publication, 5.26%
|
|
Electroanalysis
|
Electroanalysis
1 publication, 5.26%
|
|
Dalton Transactions
|
Dalton Transactions
1 publication, 5.26%
|
|
ACS Applied Nano Materials
|
ACS Applied Nano Materials
1 publication, 5.26%
|
|
Biomaterials Science
|
Biomaterials Science
1 publication, 5.26%
|
|
Pharmaceutics
|
Pharmaceutics
1 publication, 5.26%
|
|
New Journal of Chemistry
|
New Journal of Chemistry
1 publication, 5.26%
|
|
Molecules
|
Molecules
1 publication, 5.26%
|
|
Russian Journal of Inorganic Chemistry
|
Russian Journal of Inorganic Chemistry
1 publication, 5.26%
|
|
Analytica Chimica Acta
|
Analytica Chimica Acta
1 publication, 5.26%
|
|
Biotechnology and Bioengineering
|
Biotechnology and Bioengineering
1 publication, 5.26%
|
|
1
|
Citations by publishers
|
1
2
3
4
5
|
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
5 publications, 26.32%
|
|
Elsevier
|
Elsevier
3 publications, 15.79%
|
|
Wiley
|
Wiley
3 publications, 15.79%
|
|
Royal Society of Chemistry (RSC)
|
Royal Society of Chemistry (RSC)
3 publications, 15.79%
|
|
World Scientific
|
World Scientific
1 publication, 5.26%
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
1 publication, 5.26%
|
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
1 publication, 5.26%
|
|
Pleiades Publishing
|
Pleiades Publishing
1 publication, 5.26%
|
|
1
2
3
4
5
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2021,2022,2023,2024],"ids":[0,0,0,0],"codes":[0,0,0,0],"imageUrls":["","","",""],"datasets":[{"label":"Citations number","data":[2,9,6,2],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["10.53","47.37","31.58","10.53"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["International Journal of Molecular Sciences","Journal of Porphyrins and Phthalocyanines","Antioxidants","Biosensors","Frontiers in Materials","Photodiagnosis and Photodynamic Therapy","Vibrational Spectroscopy","Luminescence","Electroanalysis","Dalton Transactions","ACS Applied Nano Materials","Biomaterials Science","Pharmaceutics","New Journal of Chemistry","Molecules","Russian Journal of Inorganic Chemistry","Analytica Chimica Acta","Biotechnology and Bioengineering"],"ids":[14627,9848,16381,5233,25032,7488,25060,11836,11049,8473,1600,12476,4502,1404,1770,426,19094,18397],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/jZQkhOOcY9wrGwZm7XGRwMe8H7fThQu3KamISuun_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Elsevier","Wiley","Royal Society of Chemistry (RSC)","World Scientific","Frontiers Media S.A.","American Chemical Society (ACS)","Pleiades Publishing"],"ids":[202,17,11,123,23,208,40,101],"codes":[0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/jZQkhOOcY9wrGwZm7XGRwMe8H7fThQu3KamISuun_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp"],"datasets":[{"label":"","data":[5,3,3,3,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[26.32,15.79,15.79,15.79,5.26,5.26,5.26,5.26],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Menilli L. et al. Graphene Oxide and Graphene Quantum Dots as Delivery Systems of Cationic Porphyrins: Photo-Antiproliferative Activity Evaluation towards T24 Human Bladder Cancer Cells // Pharmaceutics. 2021. Vol. 13. No. 9. p. 1512.
GOST all authors (up to 50)
Copy
Menilli L., Monteiro A. R., Lazzarotto S., Morais F. M. P., Gomes A. T. P. C., Moura N., Fateixa S., Faustino M. A., Neves M. C. D., Trindade T., Miolo G. Graphene Oxide and Graphene Quantum Dots as Delivery Systems of Cationic Porphyrins: Photo-Antiproliferative Activity Evaluation towards T24 Human Bladder Cancer Cells // Pharmaceutics. 2021. Vol. 13. No. 9. p. 1512.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/pharmaceutics13091512
UR - https://doi.org/10.3390%2Fpharmaceutics13091512
TI - Graphene Oxide and Graphene Quantum Dots as Delivery Systems of Cationic Porphyrins: Photo-Antiproliferative Activity Evaluation towards T24 Human Bladder Cancer Cells
T2 - Pharmaceutics
AU - Monteiro, Ana R
AU - Lazzarotto, Silvia
AU - Morais, Filipe M P
AU - Menilli, Luca
AU - Gomes, Ana T P C
AU - Moura, N.
AU - Fateixa, Sara
AU - Faustino, Maria AF
AU - Neves, M. C. D.
AU - Trindade, Tito
AU - Miolo, Giorgia
PY - 2021
DA - 2021/09/18 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1512
IS - 9
VL - 13
PMID - 34575587
SN - 1999-4923
ER -
Cite this
BibTex
Copy
@article{2021_Menilli,
author = {Ana R Monteiro and Silvia Lazzarotto and Filipe M P Morais and Luca Menilli and Ana T P C Gomes and N. Moura and Sara Fateixa and Maria AF Faustino and M. C. D. Neves and Tito Trindade and Giorgia Miolo},
title = {Graphene Oxide and Graphene Quantum Dots as Delivery Systems of Cationic Porphyrins: Photo-Antiproliferative Activity Evaluation towards T24 Human Bladder Cancer Cells},
journal = {Pharmaceutics},
year = {2021},
volume = {13},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {sep},
url = {https://doi.org/10.3390%2Fpharmaceutics13091512},
number = {9},
pages = {1512},
doi = {10.3390/pharmaceutics13091512}
}
Cite this
MLA
Copy
Menilli, Luca, et al. “Graphene Oxide and Graphene Quantum Dots as Delivery Systems of Cationic Porphyrins: Photo-Antiproliferative Activity Evaluation towards T24 Human Bladder Cancer Cells.” Pharmaceutics, vol. 13, no. 9, Sep. 2021, p. 1512. https://doi.org/10.3390%2Fpharmaceutics13091512.