Open Access
Viruses, volume 13, issue 6, pages 978
Novel Acinetobacter baumannii Myovirus TaPaz Encoding Two Tailspike Depolymerases: Characterization and Host-Recognition Strategy
Shchurova Anastasia S
1, 2
,
Shneider M.
3
,
Shashkov Alexander S.
4
,
Chizhov Alexander O
4
,
Skryabin Yury P.
2
,
Mikhaylova Yulia
5
,
Sokolova Olga S.
6, 7
,
Шеленков А. А.
5
,
Knirel Yuriy A.
4
,
5
Publication type: Journal Article
Publication date: 2021-05-25
PubMed ID:
34070371
Infectious Diseases
Virology
Abstract
Acinetobacter baumannii, one of the most significant nosocomial pathogens, is capable of producing structurally diverse capsular polysaccharides (CPSs) which are the primary receptors for A. baumannii bacteriophages encoding polysaccharide-degrading enzymes. To date, bacterial viruses specifically infecting A. baumannii strains belonging to more than ten various capsular types (K types) were isolated and characterized. In the present study, we investigate the biological properties, genomic organization, and virus–bacterial host interaction strategy of novel myovirus TaPaz isolated on the bacterial lawn of A. baumannii strain with a K47 capsular polysaccharide structure. The phage linear double-stranded DNA genome of 93,703 bp contains 178 open reading frames. Genes encoding two different tailspike depolymerases (TSDs) were identified in the phage genome. Recombinant TSDs were purified and tested against the collection of A. baumannii strains belonging to 56 different K types. One of the TSDs was demonstrated to be a specific glycosidase that cleaves the K47 CPS by the hydrolytic mechanism.
Citations by journals
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1
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3
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
3 publications, 42.86%
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Viruses
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Viruses
2 publications, 28.57%
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Antibiotics
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Antibiotics
2 publications, 28.57%
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1
2
3
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Citations by publishers
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1
2
3
4
5
6
7
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
7 publications, 100%
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1
2
3
4
5
6
7
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Shchurova A. S. et al. Novel Acinetobacter baumannii Myovirus TaPaz Encoding Two Tailspike Depolymerases: Characterization and Host-Recognition Strategy // Viruses. 2021. Vol. 13. No. 6. p. 978.
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Shchurova A. S., Shneider M., Arbatsky N. P., Shashkov A. S., Chizhov A. O., Skryabin Y. P., Mikhaylova Y., Sokolova O. S., Шеленков А. А., Miroshnikov K. A., Knirel Y. A., Popova A. V. Novel Acinetobacter baumannii Myovirus TaPaz Encoding Two Tailspike Depolymerases: Characterization and Host-Recognition Strategy // Viruses. 2021. Vol. 13. No. 6. p. 978.
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TY - JOUR
DO - 10.3390/v13060978
UR - https://doi.org/10.3390%2Fv13060978
TI - Novel Acinetobacter baumannii Myovirus TaPaz Encoding Two Tailspike Depolymerases: Characterization and Host-Recognition Strategy
T2 - Viruses
AU - Shchurova, Anastasia S
AU - Arbatsky, Nikolay P.
AU - Shashkov, Alexander S.
AU - Chizhov, Alexander O
AU - Knirel, Yuriy A.
AU - Shneider, M.
AU - Skryabin, Yury P.
AU - Mikhaylova, Yulia
AU - Sokolova, Olga S.
AU - Шеленков, А. А.
AU - Miroshnikov, K. A.
AU - Popova, Anastasiya V.
PY - 2021
DA - 2021/05/25 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 978
IS - 6
VL - 13
PMID - 34070371
SN - 1999-4915
ER -
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@article{2021_Shchurova,
author = {Anastasia S Shchurova and Nikolay P. Arbatsky and Alexander S. Shashkov and Alexander O Chizhov and Yuriy A. Knirel and M. Shneider and Yury P. Skryabin and Yulia Mikhaylova and Olga S. Sokolova and А. А. Шеленков and K. A. Miroshnikov and Anastasiya V. Popova},
title = {Novel Acinetobacter baumannii Myovirus TaPaz Encoding Two Tailspike Depolymerases: Characterization and Host-Recognition Strategy},
journal = {Viruses},
year = {2021},
volume = {13},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {may},
url = {https://doi.org/10.3390%2Fv13060978},
number = {6},
pages = {978},
doi = {10.3390/v13060978}
}
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MLA
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Shchurova, Anastasia S., et al. “Novel Acinetobacter baumannii Myovirus TaPaz Encoding Two Tailspike Depolymerases: Characterization and Host-Recognition Strategy.” Viruses, vol. 13, no. 6, May. 2021, p. 978. https://doi.org/10.3390%2Fv13060978.